Anatomy of Secretory Glands in the Eyelid and Conjunctiva

Takahashi, Yasuhiro; Watanabe, Akihide; Matsuda, Hiromichi; Nakamura, Yasuhisa; Nakano, Takashi; Asamoto, Ken; Ikeda, Hiroshi; Kakizaki, Hirohiko

doi:10.1097/iop.0b013e3182833dee

Cited by 46 publications

(36 citation statements)

References 32 publications

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“…It is typically located in the nasal cavity and paranasal sinuses. [1][2][3] Orbital involvement usually results from direct extension of contiguous structures; however, the orbit may be the first and unique place of NKTCL's manifestation, 2 as reported in this case. In general, extranodal NKTCL has a highly aggressive behavior with poor response to radiotherapy and chemotherapy, and therefore poor prognosis.…”

mentioning

confidence: 64%

“…1 The orbital lobe is situated anterior to the palpebral lobe and extends superiorly within the lacrimal fossa, while the palpebral lobe is positioned posteriorly and extends inferiorly, beyond the band, with 2 to 5 ducts emptying into the lower conjunctival fornix. 2 In the setting of lacrimal gland prolapse, which commonly occurs in patients older than 60 years, 3 the gland extends beyond the normal anatomical borders, placing it at increased risk for surgical injury. Postoperative changes such as inflammation and fibrosis can also alter normal anatomy.…”

Section: Discussionmentioning

confidence: 99%

“…In general, extranodal NKTCL has a highly aggressive behavior with poor response to radiotherapy and chemotherapy, and therefore poor prognosis. [1][2][3][4][5][6][7] …”

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confidence: 99%

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Case of the Weeping Wound

Clark

Dubovy

Shriver

2014

Ophthalmic Plastic &Amp; Reconstructive Surgery

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An 87-year-old woman presented with a subcutaneous fluid collection overlying the right lateral orbital rim 2 days after undergoing a lateral tarsal strip. Drainage and excision of fibrinous granulation tissue occurred twice within the first postoperative month, with the formation of a lacrimal pseudocyst. The pseudocyst repeatedly enlarged following drainage, necessitating 4 needle aspirations. A third attempt at excision, coupled with cautery to the wound base, and loose wound closure succeeded in breaking the cycle of pseudocyst recurrence. However, the wound continued to drain, so aggressive cautery and botulinum toxin were used to obliterate the area of presumed lacrimal gland laceration and slow tear production. The possibility of damage to the lacrimal system should be entertained in the scenario of a postoperative weeping wound. Formation of a lacrimal pseudocyst should be considered when a cystic lesion appears following surgical intervention in the lateral canthal region.

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confidence: 64%

Section: Discussionmentioning

confidence: 99%

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Case of the Weeping Wound

Clark

Dubovy

Shriver

2014

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…Our findings as well as those carried out on the red kangaroo (Klećkowska-Nawrot, Goździewska-Harłajczuk, ) and other animals revealed the presence of numerous tarsal glands-yellow columns arranged parallel to each other and perpendicular to the posterior palpebral margin (Al-Ramadan, 2015;Fahmy, Arnautovic, & Abdal, 1971;Gilbart, Rossi, & Heyda, 1989;Hoffman, Miller, Marchinton, & Osborn, 1997;Knop & Knop, 2009;Osborn et al, 2000;Rehorek, Hillenius, Leigh, et al 2010;Sullivan, Dartt, & Meneray, 1998). These glands were also studied in primates (humans and rhesus monkey, Macaca mulatta) and non-primate mammals (cattle, goats, sheep, horses, dogs, cats, rabbits, white-tailed deer and brown brocket deer) (Ajmat, Chamut, & Black-Decima, 2004;Al-Ramadan, 2015;Downing, Stewart, Wertz, & Colton, 1987;Gassett & Miller, 1997;Ibrahim, Keldany, & Taha, 1992;Ikeda, 1953;Knop & Knop, 2009;Nickel et al, 2004;Osborn et al, 2000;Stephens et al, 1989;Stoeckelhuber, Stoeckelhuber, & Welsch, 2003, 2004Takahashi et al, 2013). Rehorek, Hillenius, Bhatnagar, (2010) did not find tarsal glands in the posterior palpebral eyelid margin in foetal bat specimens.…”

Section: Discussionmentioning

confidence: 99%

Microstructure of the eye tunics, eyelids and ocular glands of the Sulawesi bear cuscus (Ailurops ursinusTemminck, 1824) (Phalangeridae: Marsupialia) based on anatomical, histological and histochemical studies

Klećkowska‐Nawrot

Goździewska‐Harłajczuk

Darska

et al. 2018

Acta Zoologica

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This study described the anatomy, histology and the histochemical analysis of the eye tunics, the upper and lower eyelid, the third eyelid, the lacrimal gland and the superficial gland of the third eyelid in adult Sulawesi bear cuscus. The eyeball and the eyelids with the orbital glands were harvested immediately post‐mortem. The eyeball in the Sulawesi bear cuscus had a sphere‐like shape. The pupil was round, and the lens was a circular biconvex body. There was neither tapetum lucidum nor Harderian gland. Similarly, there were no eyelashes in the lower eyelid. The lymphoid follicles and the high endothelial venules (HEV) were found in the lymphoid region only in the third eyelid and in the connective tissue of the superficial gland of the third eyelid. The third eyelid in the bear cuscus resembled the letter “T.” The lacrimal gland and superficial gland of the third eyelid were multilobar tubuloacinar glands. The histological analysis and histochemical studies showed that the lacrimal gland in the Sulawesi bear cuscus produced a mucoserous secretion with predominantly serous cells. In contrast, the superficial gland of the third eyelid produced a serous secretion with a single acinus mucous in character.

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“…One, human tissue is not frequently accessible and, when available, is limited in quantity 11 . Two, ALG and MLG cell surface markers are frequently present in other surrounding tissues, like conjunctiva 12, 13 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Accessory Lacrimal Gland in Muller’s Muscle Conjunctival Resection Specimens for Precursor Cell Markers and Biological Markers of Dry Eye Disease

Ali

Shah

Pasha

et al. 2016

Current Eye Research

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Purpose The accessory lacrimal glands (ALG) are an understudied component of the tear functional unit, even though they are important in the development of dry eye syndrome (DES). To advance our understanding of aging changes, regenerative potential and histologic correlates to human characteristics, we investigated human ALG tissue from surgical samples to determine the presence or absence of progenitor cell markers and lacrimal epithelial markers and to correlate marker expression to relevant patient characteristics. Materials and Methods ALG tissues obtained from Muller’s Muscle Conjunctival Resection (MMCR) specimens were created using tissue microarrays (TMAs). Immunofluorescence staining of MMCR sections was performed using primary antibodies specific to cell protein markers. Cell marker localization in TMAs was then assessed by two blinded observers using a standardized scoring system. Patient characteristics including age, race, and status of ocular surface health were then compared against expression of stem cell markers. Results Human ALG expressed a number of epithelial markers, and in particular, histatin-1 was well correlated with the expression of epithelial markers and was present in most acini. In addition, we noted the presence of precursor cell markers nestin, ABCG2 and CD90 in ALG tissue. There was a decrease in precursor cell marker expression with increasing age. Finally, we noted that a negative association was present between histatin-1 expression and DES. Conclusions Thus, we report for the first time that human ALG tissues contain precursor marker positive cells and that this marker expression may decrease with increasing age. Moreover, histatin-1 expression may be decreased in DES. Future studies will be performed to use these cell markers to isolate and culture lacrimal epithelial cells from heterogeneous tissues, determine the relevance of histatin-1 expression to DES and isolate candidate precursor cells from ALG tissue.

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Anatomy of Secretory Glands in the Eyelid and Conjunctiva

Cited by 46 publications

References 32 publications

Case of the Weeping Wound

Case of the Weeping Wound

Microstructure of the eye tunics, eyelids and ocular glands of the Sulawesi bear cuscus (Ailurops ursinusTemminck, 1824) (Phalangeridae: Marsupialia) based on anatomical, histological and histochemical studies

Evaluation of Accessory Lacrimal Gland in Muller’s Muscle Conjunctival Resection Specimens for Precursor Cell Markers and Biological Markers of Dry Eye Disease

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