Anatomy, Physiology, and Behavior

Sohn, Joanne J.; Couto, Marcelo

doi:10.1016/b978-0-12-380920-9.00008-0

Cited by 23 publications

(56 citation statements)

References 73 publications

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“…This applies to all of the teeth in the rabbit dental arcade (i.e., incisors, premolars, and molars; rabbits do not have canines). This contrasts with rodents, where the incisors are the only open-rooted (or hypsodontic) teeth (Sohn and Couto, 2012). Thus, rabbit teeth are subject to overgrowth.…”

Section: Normative Biologymentioning

confidence: 95%

“…The ears also serve as a means of thermoregulation, as excess heat may be exchanged across the large surface area of the ears (Sohn and Couto, 2012). The skin of rabbits lacks sweat glands and is therefore unable to sweat; panting is insufficient to dissipate the excess heat (Sohn and Couto, 2012). Thus, the ears play a vital role in maintaining proper body temperature.…”

Section: Normative Biologymentioning

confidence: 99%

“…Other unique features of the skin and adnexa are the presence of chin and inguinal glands used in scent marking. Additionally, the female rabbit (doe) is noted by the presence of a large skin fold filled with subcutaneous fat just under the chin (the dewlap) (Sohn and Couto, 2012).…”

Section: Normative Biologymentioning

confidence: 99%

“…Thus, rabbit teeth are subject to overgrowth. Another unique feature of rabbit dentition that sets them apart from rodents is the presence of a second set of incisors just behind the first set of upper incisors known as "peg" teeth (Sohn and Couto, 2012). They are thought to aid in tearing off the succulent leaves of plants while grazing.…”

Section: Normative Biologymentioning

confidence: 99%

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Commonly Used Animal Models

Hickman

Johnson

Vemulapalli

et al. 2017

Principles of Animal Research

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Section: Normative Biologymentioning

confidence: 95%

Section: Normative Biologymentioning

confidence: 99%

Section: Normative Biologymentioning

confidence: 99%

Section: Normative Biologymentioning

confidence: 99%

See 2 more Smart Citations

Commonly Used Animal Models

Hickman

Johnson

Vemulapalli

et al. 2017

Principles of Animal Research

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“…The soft tissue structure containing the diverticulum of this rabbit arose from the dorsal aspect of the prostate running in an anterior direction dorsally over the bladder. The prostate of rabbits has several small ducts entering both sides of the urethra (Sohn and Couto 2012). Possible aetiologies would be an embryological or ductal remnant, but given the cellular structure of the diverticulum the latter is less likely.…”

Section: Outcome and Follow-upmentioning

confidence: 99%

Urethral diverticulum in a male pet rabbit

Schuhmann¹,

Cope²

2014

Vet Record Case Reports

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A two-year-old, male neutered French lop rabbit (Oryctolagus cuniculus) was presented for urinary scalding and wetting. Radiographs showed a small gas-filled structure caudodorsal to the urinary bladder that was shown to be connected to the urethra just caudal to the bladder neck and cranial to the external urethral sphincter in urethrograms. The clinical findings and the surgical procedure to correct the condition are described. To the author's knowledge, this is the first report of a urethral diverticulum in a rabbit.

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Animal modeling in bone research—Should we follow the White Rabbit?

Macedo

Feitosa

Kawamoto

et al. 2019

Anim Models and Exp Med

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In the long history of mankind, animals have played significant roles.We owe much of our intellectual sophistication and societal status to animal husbandry. 1 Farming and agriculture have allowed humans to control their environment and an improved nutrition. The first rural settlements marked the birth of the ancient civilizations, 2 but also triggered the first zoonotic outbreaks and the beginning of public health concerns. 3 The earliest records of animal use coincide with the appearance of Hippocrates' concepts and the birth of Western medicine. 2 Jumping ahead 2400 years, in the year 2018 more than 20 000 animal subjects-exceeding 200 species-were part of translational studies worldwide, 4 in pre-clinical trials. 2 Animal modelling can provide reliable data to elucidate human diseases. 5 Despite benefiting our quality of life, animal research remains controversial. 3 There is a growing sense of disapproval over using household pets in experiments. 1 New technologies have been created to replace animals in research, but the position of ideal bone substitute remains open. 6 Thus, primary research on novel models continues paramount. 7 AbstractAnimal models are live subjects applied to translational research. They provide insights into human diseases and enhance biomedical knowledge. Livestock production has favored the pace of human social development over millennia. Today's society is more aware of animal welfare than past generations. The general public has marked objections to animal research and many species are falling into disuse. The search for an ideal methodology to replace animal use is on, but animal modeling still holds great importance to human health. Bone research, in particular, has unmet requirements that in vitro technologies cannot yet fully address. In that sense, standardizing novel models remains necessary and rabbits are gaining in popularity as potential bone models. Our aim here is to provide a broad overview of animal modeling and its ethical implications, followed by a narrower focus on bone research and the role rabbits are playing in the current scenario. K E Y W O R D Sanimal experimentation, bone density, Lagomorpha, translational medical research MACEDO Et Al.

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Anatomy, Physiology, and Behavior

Cited by 23 publications

References 73 publications

Commonly Used Animal Models

Commonly Used Animal Models

Urethral diverticulum in a male pet rabbit

Animal modeling in bone research—Should we follow the White Rabbit?

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