Anchored quaternary ammonium salts adsorbed on polyurethane film surfaces

Mathew, Rachel; Cooney, Ralph P.; Doyle, Carol; Swift, Simon; Haessler, Christian

doi:10.1016/j.porgcoat.2019.105343

Cited by 10 publications

(6 citation statements)

References 42 publications

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“…An antibacterial film is another antibacterial surface in addition to the antibacterial coating, which has attracted considerable attention in water treatment because of its porous structure and ease of manufacture. , A common way to prepare antibacterial membranes is to inactivate bacteria by adding an antibacterial active substance, such as Ag + , to a polymer matrix, and common matrices include polyurethane, chitosan, and chitin . QASs can be also introduced into the polymer as an antibacterial active substance through physical blending or chemical covalent bonding to improve the antibacterial effect and mechanical properties of the membrane. , The main role of QASs in the antibacterial membrane includes two aspects: (1) as a hydrophilic substance, QASs enhances the hydrophilicity of the membrane and reduces the adhesion of bacteria; and (2) as a broad-spectrum antibacterial agent, they kill bacteria on the surface of the membrane by contact to remove biofilm . In specific applications, QASs are usually combined with other antibacterial substances, such as AgNPs and carbon-based materials, using their different bactericidal mechanisms to play a synergistic antibacterial role such as electrostatic adsorption and topology. − Here, we mainly discuss membranes with different film-forming substrates, specifically polymers and natural polymers (Table ).…”

Section: Application Of Qassmentioning

confidence: 99%

“…123,124 A common way to prepare antibacterial membranes is to inactivate bacteria by adding an antibacterial active substance, such as Ag + , to a polymer matrix, 125 and common matrices include polyurethane, 126 chitosan, 127 and chitin. 128 QASs can be also introduced into the polymer as an antibacterial active substance through physical blending 129 or chemical covalent bonding 130 to improve the antibacterial effect and mechanical properties of the membrane. 131,132 The main role of QASs in the antibacterial membrane includes two aspects: (1) as a hydrophilic substance, QASs enhances the hydrophilicity of the membrane and reduces the adhesion of 2) as a broad-spectrum antibacterial agent, they kill bacteria on the surface of the membrane by contact to remove biofilm.…”

Section: Qass Antibacterialmentioning

confidence: 99%

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Quaternary Ammonium Salts: Insights into Synthesis and New Directions in Antibacterial Applications

Zhou

Zhou²,

Zhang

et al. 2023

Bioconjugate Chem.

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The overuse of antibiotics has led to the emergence of a large number of antibiotic-resistant genes in bacteria, and increasing evidence indicates that a fungicide with an antibacterial mechanism different from that of antibiotics is needed. Quaternary ammonium salts (QASs) are a biparental substance with good antibacterial properties that kills bacteria through simple electrostatic adsorption and insertion into cell membranes/altering of cell membrane permeability. Therefore, the probability of bacteria developing drug resistance is greatly reduced. In this review, we focus on the synthesis and application of single-chain QASs, double-chain QASs, heterocyclic QASs, and gemini QASs (GQASs). Some possible structure–function relationships of QASs are also summarized. As such, we hope this review will provide insight for researchers to explore more applications of QASs in the field of antimicrobials with the aim of developing systems for clinical applications.

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Section: Application Of Qassmentioning

confidence: 99%

Section: Qass Antibacterialmentioning

confidence: 99%

Quaternary Ammonium Salts: Insights into Synthesis and New Directions in Antibacterial Applications

Zhou

Zhou²,

Zhang

et al. 2023

Bioconjugate Chem.

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“…The antibacterial properties of WPU are mainly due to the presence of QAS, which interacts with the bacterial membranes and disturbs its cytoplasmic contents. Mathew et al 164 prepared a PU film with QAS anchored on its surface and evaluated its antibacterial behavior using the wet fomite method. The resultant PU/QAS film exhibited a 3-log (99.9%) reduction of bacterial growth for both E. coli and S. aureus bacterial strains.…”

Section: Quaternary Ammonium Salts-and Zwitterions-based Polyurethane...mentioning

confidence: 99%

Polyurethane‐basedcomposites with promising antibacterial properties

Kasi

Sathishkumar

Zhang

et al. 2022

J of Applied Polymer Sci

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Polyurethane (PU) is a well-known synthetic polymer consisting of isocyanates, polyols, and chain extenders. The incorporation of fillers into the PU polymeric matrix, including inorganic nanomaterials, synthetic polymers, natural components, quaternary ammonium salts, and commercial drugs, bestows the endproducts with unique and improved physicochemical properties. Fillers can be used to tailor the molecular orientation, crystallinity, cross-linking, and functional chemical groups of PU-based composites. The bactericidal ability of PU composites highly depends on their surface composition, morphology, charge, and stability. Recent advancements highlight the potential of PU composites in combating bacterial infections. In this review, the cutting-edge of inorganic and organicbased PU composites for antibacterial applications is addressed. Notably, selective examples of scientific reports' key findings and their crucial information on PU composites are discussed. Furthermore, the positive impact of PU composites on the future prospects of this field is explored. This review comprehensively deliberates the values of PU composites towards practical applications in the biomedical field of antibacterial activity. This review can help researchers to gain widespread knowledge and a better understanding of PU composites for antibacterial applications.

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“…There is no single test method that evaluates the efficacy of antimicrobial surface designs, as the method used may vary based on the mechanism of action and the properties of the surface material. The JIS Z 2801 and ISO 22196 protocols represent a commonly cited standard assay for checking the antimicrobial potency of a surface incorporated with a biocide (Hauser & Wunderlich, 2011 ; Mathew et al, 2020 ; Michels et al, 2009 ). Here we have used the assay protocol to check the antimicrobial potency of SAQAS biocides in wet conditions and adapted the inoculation protocol to test biocides in dry conditions.…”

Section: Discussionmentioning

confidence: 99%

The antibacterial potency and antibacterial mechanism of a commercially available surface-anchoring quaternary ammonium salt (SAQAS)-based biocide in vitro

Nair

Anand

Silva

et al. 2022

Journal of Applied Microbiology

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Aims To determine the antimicrobial potency of a surface‐anchored quaternary ammonium salt (SAQAS)‐based biocide during in vitro wet and dry fomite assays and to determine the mechanism of killing bacteria on the surface. Methods and Results Wet and dry fomite assays were established in vitro for a commercially available biocide (SAQAS‐A) applied to glass and low‐density polyethylene (LDPE) surfaces. Both wet and dry fomite tests showed the active killing of Gram‐positive and Gram‐negative bacteria but not endospores. Assays measuring membrane permeability (ATP and DNA release), bacterial membrane potential and bacterial ROS production were correlated with the time‐to‐kill profiles to show SAQAS‐A activity in suspension and applied to a surface. Conclusions SAQAS‐A is an effective biocide against model strains of vegetative bacteria. The killing mechanism for SAQAS‐A observed minimal membrane depolarization, a surge in ROS production and assessment of membrane permeability supported the puncture of cells in both suspension and surface attachment, leading to cell death. Significance and Impact of the study SAQAS represents effective surface biocides against single challenges with bacteria through a mechanical killing ability that supports real‐world application if their durability can be demonstrated to maintain residual activity.

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Anchored quaternary ammonium salts adsorbed on polyurethane film surfaces

Cited by 10 publications

References 42 publications

Quaternary Ammonium Salts: Insights into Synthesis and New Directions in Antibacterial Applications

Quaternary Ammonium Salts: Insights into Synthesis and New Directions in Antibacterial Applications

Polyurethane‐basedcomposites with promising antibacterial properties

The antibacterial potency and antibacterial mechanism of a commercially available surface-anchoring quaternary ammonium salt (SAQAS)-based biocide in vitro

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