Ancillary factors in the treatment of orofacial pain: A topical narrative review

Melis, Marcello; Giosia, Massimiliano Di; Colloca, Luana

doi:10.1111/joor.12736

Cited by 9 publications

(6 citation statements)

References 62 publications

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“…TMDs are often self-limited over time, and significant fluctuation of the symptoms can be observed [44,45]; therefore, we cannot determine if the changes observed in both groups can be specifically attributed to interventions or simply the passage of time. Future clinical trials should include a real control group that does not receive any intervention to determine the real effects of the therapy.…”

Section: Discussionmentioning

confidence: 99%

Effects of Cervico-Mandibular Manual Therapy in Patients with Temporomandibular Pain Disorders and Associated Somatic Tinnitus: A Randomized Clinical Trial

et al. 2019

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Objective This randomized clinical trial investigated the effects of adding cervico-mandibular manual therapies into an exercise and educational program on clinical outcomes in individuals with tinnitus associated with temporomandibular disorders (TMDs). Methods Sixty-one patients with tinnitus attributed to TMD were randomized into the physiotherapy and manual therapy group or physiotherapy alone group. All patients received six sessions of physiotherapy treatment including cranio-cervical and temporomandibular joint (TMJ) exercises, self-massage, and patient education for a period of one month. Patients allocated to the manual therapy group also received cervico-mandibular manual therapies targeting the TMJ and cervical and masticatory muscles. Primary outcomes included TMD pain intensity and tinnitus severity. Secondary outcomes included tinnitus-related handicap (Tinnitus Handicap Inventory [THI]), TMD-related disability (Craniofacial Pain and Disability Inventory [CF-PDI]), self-rated quality of life (12-item Short Form Health Survey [SF-12]), depressive symptoms (Beck Depression Inventory [BDI-II]), pressure pain thresholds (PPTs), and mandibular range of motion. Patients were assessed at baseline, one week, three months, and six months after intervention by a blinded assessor. Results The adjusted analyses showed better outcomes (all, P < 0.001) in the exercise/education plus manual therapy group (large effect sizes) for TMD pain (η 2 P = 0.153), tinnitus severity (η 2 P = 0.233), THI (η 2 P = 0.501), CF-PDI (η 2 P = 0.395), BDI-II (η 2 P = 0.194), PPTs (0.363 < η 2 P < 0.415), and range of motion (η 2 P = 0.350), but similar changes for the SF-12 (P = 0.622, η 2 P = 0.01) as the exercise/education alone group. Conclusions This clinical trial found that application of cervico-mandibular manual therapies in combination with exercise and education resulted in better outcomes than application of exercise/education alone in individuals with tinnitus attributed to TMD.

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Section: Discussionmentioning

confidence: 99%

Effects of Cervico-Mandibular Manual Therapy in Patients with Temporomandibular Pain Disorders and Associated Somatic Tinnitus: A Randomized Clinical Trial

et al. 2019

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“…Orofacial pain is the pain caused by damage to the branches of the trigeminal nerve or neurogenic inflammation that spreads to the orofacial area [1,2]. It accounts for approximately 10% to 26% of the adult population; in 7-11% of this population, it is classified as chronic and constitutes a serious medical and social problem [3,4]. Although the exact etiopathogenesis of most orofacial pain complaints has not been fully elucidated, recent findings suggest that the endoopioid (EOS) and endocannabinoid (ECS) systems have similar pharmacological characteristics, are frequently co-localized and exert a strong analgesic effect mainly through activation of the µ -opioid (MOR) and cannabinoid (CBR) receptors [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats

Zubrzycki

Zubrzycka

Wysiadecki

et al. 2022

IJMS

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Endocannabinoids act as analgesic agents in a number of headache models. However, their effectiveness varies with the route of administration and the type of pain. In this study, we assessed the role of the fatty acid amide hydrolase inhibitor URB597 in an animal model of orofacial pain based on tooth pulp stimulation. More specifically, we assessed the effects of intracerbroventricular (i.c.v.) and intraperitoneal (i.p.) administration of URB597 on the amplitude of evoked tongue jerks (ETJ) in rats. The levels of the investigated mediators anandamide (AEA), 2-arachidonyl glycerol (2-AG), Substance P (SP), calcitonin-gene-related peptide (CGRP), endomorphin-2 (EM-2) and fatty acid amide hydrolase (FAAH) inhibitor by URB597 and receptors cannabinoid type-1 receptors (CB1R), cannabinoid type-2 receptors (CB2R) and µ-opioid receptors (MOR) were determined in the mesencephalon, thalamus and hypothalamus tissues. We have shown that increasing endocannabinoid AEA levels by both central and peripheral inhibition of FAAH inhibitor by URB597 has an antinociceptive effect on the trigemino-hypoglossal reflex mediated by CB1R and influences the activation of the brain areas studied. On the other hand, URB597 had no effect on the concentration of 2-AG in the examined brain structures and caused a significant decrease in CB2R mRNA expression in the hypothalamus only. Tooth pulp stimulation caused in a significant increase in SP, CGRP and EM-2 gene expression in the midbrain, thalamus and hypothalamus. In contrast, URB597 administered peripherally one hour before stimulation decreased the mRNA level of these endogenous neuropeptides in comparison with the control and stimulation in all examined brain structures. Our results show that centrally and peripherally administered URB597 is effective at preventing orofacial pain by inhibiting AEA catabolism and reducing the level of CGRP, SP and EM-2 gene expression and that AEA and 2-AG have different species and model-specific regulatory mechanisms. The data presented in this study may represent a new promising therapeutic target in the treatment of orofacial pain.

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“…Revisão bibliográfica do tipo narrativa, com abordagem qualitativa (Melis et al 2019;Aidos et al 2018). Foi realizado um levantamento bibliográfico para identificar os principais artigos que buscaram explicar a adesão à higienização das mãos pelos profissionais de saúdes em hospitais na pandemia da COVID-19.…”

Section: Metodologiaunclassified

Adesão à higienização das mãos como controle de infecção hospitalar na pandemia da COVID-19: Revisão bibliográfica

Malinconico

2021

RSD

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Objetivo: Verificar a adesão à higienização das mãos por profissionais de saúde no combate à pandemia da COVID-19. Metodologia: Foram revisados artigos encontrados nas bases de dados PubMed/MEDLINE, SCOPUS e Cochrane Libraryoram definidos os seguintes critérios de inclusão: estudos transversais realizados por meio de observação ou questionário que avaliaram a adesão dos profissionais de saúde à higienização das mãos durante a pandemia da COVID-19, publicados de janeiro de 2020 a maio de 2021. Após as buscas, os artigos selecionados pelos resumos foram lidos na íntegra Foram excluídos os estudos que não especificaram o período em que foram realizados. Resultados: 331 artigos foram encontrados, no entanto somente 23 foram incluídos na revisão bibliográfica, mostrando que a observação mais prevalente foi em relação a exposição ou momento da higienização das mãos, avaliada em 11 estudos. Conclusão: A taxa de adesão à higienização das mãos na pandemia mostrou-se significantemente maior em relação ao período pré-COVID-19. Os médicos e enfermeiros são os profissionais que higienizam as mãos com maior frequência durante a pandemia, principalmente após o contato com pacientes. Já os técnicos e auxiliares de enfermagem se mostraram menos adeptos. A frequência de higienização foi maior nos picos de transmissão do SARS-CoV-2.

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Ancillary factors in the treatment of orofacial pain: A topical narrative review

Cited by 9 publications

References 62 publications

Effects of Cervico-Mandibular Manual Therapy in Patients with Temporomandibular Pain Disorders and Associated Somatic Tinnitus: A Randomized Clinical Trial

Effects of Cervico-Mandibular Manual Therapy in Patients with Temporomandibular Pain Disorders and Associated Somatic Tinnitus: A Randomized Clinical Trial

Effect of Fatty Acid Amide Hydrolase Inhibitor URB597 on Orofacial Pain Perception in Rats

Adesão à higienização das mãos como controle de infecção hospitalar na pandemia da COVID-19: Revisão bibliográfica

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