Androechin, A New Chalcone Glucoside fromAndrographis Echioides

Abstract

A new chalcone glucoside, androechin, and a known flavone glucoside, echioidinin 5-O-glucoside, were isolated from the whole plant of Andrographis echioides. Androechin was characterized as 2,2',6'-trihydroxy-4'-methoxychalcone 2'-O-beta-D-glucopyranoside by spectral and chemical studies.

Antioxidative Activity of Prunus sargentii Outer Bark Extractives

“…In the HMBC spectrum of 4, correlation of methoxyl proton (δ 3.81, s), H-3' (δ 6.34, s), and H-5' (δ 6.15, s) with C-4' (δ 166.19 ) was observed. HMBC correlation of the anomeric proton (δ 5.17, d, J =7.5 Hz, H-1") with the carbon at δ 159.81 (C-2') indicated the presence of sugar moiety at C-2' position [10,11]. According to the above data comparison with the literature [11,12], the compound 4 was determined as neosakuranin, a chalcone glucoside, and reported for the first time in domestic from the outer bark of P. sargentii.…”

Flavonoid Biosynthesis

“…Glucosylated chalcones occur in other species including false waterwillow (Andrographis echioides) (Jayaprakasam et al, 2001), Canadian wildginger (Asarum canadense) (Iwashina and Kitajima, 2000), Glory Bower (aka Arni) (Clerodendron phlomidis) (Roy and Pandey, 1994) and bubinga (Guibourtia tessmanii) (Fuendjiep et al, 2002) Naringenin is a key central intermediate, as from this point onwards the flavonoid biosynthetic pathway diverges into several side-branches, each resulting in the production of different class of flavonoids, including isoflavones, flavanones, flavones, flavonols, proanthocyanidins and anthocyanins (Figure 11.2).…”

Chemical Constituents from Andrographis echioides and Their Anti-Inflammatory Activity

“…However, information on the chemical composition and bioactivity of this species is very rare. There is only report of flavonoids as major components from the extracts of A. echioides in the previous literature [11–14]. As part of our program to study the bioactive constituents from Andrographis species [15,16], we have investigated the whole plant of A. echioides and four new compounds ( 1 – 4 ) were characterized.…”