Androgen deprivation therapy's impact on the mood of prostate cancer patients as perceived by patients and the partners of patients

Abstract

Our data support ADT's impact on PCa patients' mood and verify that partners concurrently see the effects. The psychological changes related to ADT can impact relationships and affect the quality of life of both PCa patients and partners. Patients and their partners are likely to benefit from being well informed about the psychological effects of androgen deprivation on men beginning ADT. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

Trajectories of total depression and depressive symptoms in prostate cancer patients receiving six months of hormone therapy

“…Instead, these data extend those findings to identification of the actual nature of those depressive symptomatology score increases and are congruent with them. Lee et al [10] questioned whether the increases in CESD scores during HT might be a result of decreased testosterone, increases in HT side effects such as sarcopenia, hot flashes or cognitive difficulties, or other changes associated with HT, and van Dam et al [12] noted significant decreases in Vigor on the POMS during HT. The results of this study do not address that entire range of possible sources of increased depression but do argue that it was majorly sexual anhedonia that was responsible for increases in overall depression during HT.…”

“…Lee et al [10] selected the somatic symptoms of depression for special attention in their recent prospective study but did not examine other depressive symptoms. Van Dam et al [12] used six subscales of the Profile of Mood States in their study of the effects of HT as reported by PCa patients and their partners, but those subscales do not equate to the diagnostic symptoms of MDD. Sharpley et al [9] did examine a wider range of depressive symptoms that included those for MDD but did not collect prospective data.…”

“…Therefore, to further explore the nature of the depression experienced by PCa patients who received HT, to do so over the period of their HT instead of at a single point in time, and to thus inform more individualized treatment practice with these men during their HT, the present study collected data on depression and its symptoms immediately before, after 3 months, and after 6 months of HT. Because the depressive effects of HT have been well established [7][8][9][10][11][12] and because this study did not seek to replicate those results but rather to explore the nature of the depressive experience in HT PCa patients over time, only PCa patients receiving HT were recruited for the study.…”

The perspective of prostate cancer patients and patients' partners on the psychological burden of androgen deprivation and the dyadic adjustment of prostate cancer couples

“…Mood data for this sample have been previously reported by Van Dam et al . (companion paper to this one, ).…”

“…Participants rate these words using a 5‐point Likert scale to indicate how well each word describes their mood on a scale from 1 (not at all) to 5 (extremely) over the past week. Data on results from the six subscales are reported in the companion paper to this article (Van Dam et al ). For the present study, we used the total mood disturbance score, which involves summing the five negative mood subscales (Tension‐Anxiety, Depression‐Dejection, Anger‐Hostility, Fatigue‐Inertia, and Confusion‐Bewilderment) and subtracting the positive mood subscale (Vigor‐Activity).…”