Androgenetic alopecia: Update on etiology

Dhurat, Rachita; Daruwalla, Sanober Burzin

doi:10.1002/der2.58

Cited by 12 publications

(13 citation statements)

References 57 publications

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“…Androgens, male hormones, are one of the causes of AGA 4 . Although the relationship between FPHL and androgen is unclear, FPHL is accompanied by hair follicle miniaturization and hair thinning, similar to MPHL 5 . The pathogenesis of both diseases is not yet completely understood, but its incidence has increased in recent years.…”

Section: Introductionmentioning

confidence: 99%

Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia

Yun¹,

Lee²,

Goh³

et al. 2022

Sci Rep

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Androgenetic alopecia (AGA) is the most common type of hair loss in men and women. Dihydrotestosterone (DHT) and androgen receptor (AR) levels are increased in patients with AGA, and DHT-AR signaling correlates strongly with AGA pathogenesis. In this study, treatment with self-assembled micelle inhibitory RNA (SAMiRNA) nanoparticle-type siRNA selectively suppressed AR expression in vitro. Clinical studies with application of SAMiRNA to the scalp and massaging to deliver it to the hair follicle confirmed its efficacy in AGA. For identification of a potent SAMiRNA for AR silencing, 547 SAMiRNA candidates were synthesized and screened. SAMiRNA-AR68 (AR68) was the most potent and could be efficiently delivered to human follicle dermal papilla cells (HFDPCs) and hair follicles, and this treatment decreased the AR mRNA and protein levels. We confirmed that 10 µM AR68 elicits no innate immune response in human PBMCs and no cytotoxicity up to 20 µM with HFDP and HaCaT cells. Clinical studies were performed in a randomized and double-blind manner with two different doses and frequencies. In the low-dose (0.5 mg/ml) clinical study, AR68 was applied three times per week for 24 weeks, and through quantitative analysis using a phototrichogram, we confirmed increases in total hair counts. In the high-dose (5 mg/ml) clinical study, AR68 was given once per week for 24 weeks and showed 83% efficacy in increasing hair counts compared with finasteride. No side effects were observed. Therefore, SAMiRNA targeting AR mRNA is a potential novel topical treatment for AGA.

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Section: Introductionmentioning

confidence: 99%

Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia

Yun¹,

Lee²,

Goh³

et al. 2022

Sci Rep

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show abstract

“…2023;20(1):64-74 drojene duyarlı olduğu göz önüne alındığında, AR'nin, MPB için en uygun aday gen olduğu bildirilmiştir. 41 Bu bölgedeki ikinci aday gen ise EDA2R'dir. Prodi ve ark.nın yaptığı bir çalışmada ise MPB ile EDA2R geni arasında güçlü ilişki tespit edilmiştir.…”

Section: Mpb Ve Mpb Ile Ilgili Genetik çAlişmalarunclassified

Forensic DNA Phenotyping: Male Pattern Baldness: Traditional Review

ŞENIŞIK¹,

BÜLBÜL²,

FİLOĞLU³

2023

Turkiye Klinikleri J Foren Sci Leg Med

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“…Therefore, changes in structure and amount of this gene expression could cause baldness (17). Although many studies have been conducted on the expression of the SRD5A2 gene and its role in hair loss (19), the effect of this gene on the performance of hair transplantation has not yet been determined.…”

Section: Introductionmentioning

confidence: 99%

Adjuvant measures and genetic evaluations to improve results of hair transplantation

Fattah

2022

Cell Mol Biol (Noisy-le-grand)

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Follicular unit extraction (FUE) has evolved dramatically as the most recent advancement in surgical hair restoration as it leaves a tiny scar and creates natural and pleasing results. This study aims to show the effectiveness of adjuvant measures and genetic evaluations in improving outcomes. Prospective analysis of 271 male patients with androgenic alopecia who underwent hair transplantation with FUE technique between August 2015 and February 2020 at our center was conducted. The mean age was 35.93 ±4.40 years. At one year postoperatively, patients were asked to fill up a questionnaire which included their satisfaction level, need for 2nd session, and complications. Informed written consent was obtained from all patients. Also, blood samples were provided from patients before the operation. RNA extraction and cDNA synthesis were performed using the RNX-Plus kit (Cinnagen, Iran) and Vivantis kit (Malaysia). Amplification of SRD5A2 and GAPDH genes (as internal standard) for measuring gene expression was performed by real-time PCR. Data were analyzed using the statistical package for social science SPSS V. 23. In the last 156 cases, the addition of 40 mg of Triamcinolone to the LA solution led to a dramatic reduction of the incidence of postoperative oedema, from 40% to 9%. Adding three sessions of PRP at 2nd, 4th and 6th months postoperatively resulted in an increased patient satisfaction rate with better hair density and thickness where the rate of highly satisfied patients increased from 64.5% to 83.7%. The addition of 40 mg Triamcinolone to the LA solution was highly effective in reducing postoperative oedema. Three sessions of PRP at 2nd, 4th and 6th months postoperatively were recommended. The results of SRD5A2 gene expression showed that the expression of this gene in satisfied (P = 0.049) and dissatisfied (P = 0.028) patients were significantly higher than highly satisfied patients, which means that the SRD5A2 gene expression had an essential role in the successfulness of hair transplantation. The increased expression of this gene could reduce the response to hair transplantation.

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Androgenetic alopecia: Update on etiology

Cited by 12 publications

References 57 publications

Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia

Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia

Forensic DNA Phenotyping: Male Pattern Baldness: Traditional Review

Adjuvant measures and genetic evaluations to improve results of hair transplantation

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