Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease

Hidalgo, María A.; Hancke, Juan L.; Bertoglio, Juan Carlos; Burgos, Rafael A.

doi:10.5772/55642

Cited by 5 publications

(3 citation statements)

References 86 publications

(107 reference statements)

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“…36 The search for new analgesic and anti-inflammatory agents has led to the discovery that, andrographolide, which is a purified plant extract, has the ability to inhibit the formation of inflammatory cytokines, TNF-α, and interleukin-6 which are also implicated in the effect observed after carrageenan administration. 13,37 Andrographolide has also been found to possess analgesic effects in some commonly employed rodent models of analgesia. 18,38 In this study, the von Frey test 39 which employs plastic filaments of different sizes to deliver a mechanical stimulus and the Hargreaves test 40 which employs a radiant heat stimulus were used for the evaluation of allodynia and hyperalgesia in carrageenan-treated rodents.…”

Section: Discussionmentioning

confidence: 99%

“…10,11 A reduction in the dose of individual drugs needed to produce a given effect may produce a corresponding reduction in the side effect associated with the individual drugs. This study investigates the antiinflammatory and anti-hyperalgesic effect of a combination of diclofenac, which is one of the most widely used NSAIDs, 12 and andrographolide, a novel anti-rheumatic compound 13 with gastro-protective, 14 hepato-protective, 15,16 and analgesic effects 17,18 in the carrageenan-induced paw edema experiment. The study could be of relevance to clinicians as both diclofenac 19,20 and andrographolide [21][22][23] have been shown to have a potential benefit in the management of SARS-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Diclofenac and Andrographolide Combination on Carrageenan-Induced Paw Edema and Hyperalgesia in Rats

et al. 2022

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Studies into drug combination at low doses are a promising approach to the management of pain and inflammation. The aim of this study was to evaluate the anti-edema and anti-hyperalgesic effects of a combination of diclofenac and andrographolide. Male Sprague-Dawley rats were first treated with diclofenac or andrographolide alone (3–100 mg/kg), as well as a combination of the 2 drugs. Carrageenan was then injected into the right hind paw of rats, and changes in paw volume and sensitivity to mechanical (von Frey) and thermal (Hargreaves test) stimuli measured. Results showed drug combination produced synergistic effects at reducing paw edema especially at lower doses, with a Loewe synergy score of 13.02 ± 8.75 in SynergyFinder and a combination index of .41 ± .18 after isobolographic analysis. Again synergy scores for decreasing response to 1.0 and 3.6 g force application of von Frey filaments after drug combination were 10.127 ± 5.68 and 8.554 ± 6.53, respectively, in SynergyFinder. Synergistic effects were also seen after drug combination in the Hargreaves test with a synergy score of 5.136 ± 16.38. In conclusion, combination of diclofenac with andrographolide showed better pharmacologic effects after carrageenan injection and was more synergistic at low-dose combinations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Diclofenac and Andrographolide Combination on Carrageenan-Induced Paw Edema and Hyperalgesia in Rats

et al. 2022

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“…However, antioxidants of herbal origin have promise because of their minimal side effects. Andrographolide (AP), one of the plant-derived natural antioxidants, was reported to exert anti-inflammatory and anticancer effects because of its free radical scavenging ability (Chen, Hsiao, Lee, Wu, & Yen, 2004;Ding et al, 2013;Hidalgo et al, 2005;Hidalgo, Hancke, Bertoglio, & Burgos, 2013;Negi et al, 2008;Y.J. Wang, Wang, Fan, & Geng, 2007).…”

Section: Introductionmentioning

confidence: 99%

Andrographolide protects chondrocytes from oxidative stress injury by activation of the Keap1–Nrf2–Are signaling pathway

Jiang

Liu

et al. 2018

Journal Cellular Physiology

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Recent studies have shown that andrographolide (AP) has the potential to be developed as a drug for therapy for osteoarthritis (OA). However, the role of AP in attenuating the progression of OA is still unknown. We hypothesized that its therapeutic effect may be associated with its antioxidant potential. In this study, we investigated the therapeutic effect of AP on chondrocytes injured by H O and the association with the oxidation-related signaling pathways through the detection of cell proliferation, cell viability, the expression of oxidative stress-specific genes (Sod1, Cat, and malonaldehyde [Mda]) and proteins (superoxide dismutase [SOD], catalase [CAT]) after a culture period of 3 and 5 days, respectively. Further exploration of the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) messenger RNA and protein was also performed. The results showed that 0.625 µg/ml and 2.5 µg/ml of AP decreased oxidative stress injury of chondrocytes by increasing cell proliferation reduced by H O and antioxidant enzyme activity, including SOD and CAT. Inflammation factors, such as matrix metallopeptidase 13 (Mmp13), tissue inhibitor of metalloproteinase 1 (Timp1), and interleukin-6 (Il6), were downregulated in the H O group with AP, demonstrating a decrease in the progression of OA. Pathway analyses identified that the kelch-like ECH-associated protein 1 (Keap1)-Nrf2-antioxidant response element (Are) pathway is an important mediator in AP therapy on H O -induced OA. This study indicates that AP exerts protection effects on oxidative stress via activation of the Keap1-Nrf2-Are pathway in chondrocytes injured by H O , which may be promising for the therapy of OA.

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Optimization and characterization of hepatoprotective andrographolide microspheres in the necrotic rat model

Hazra

Mandal

et al. 2021

Journal of Drug Delivery Science and Technology

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Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease

Cited by 5 publications

References 86 publications

Effect of Diclofenac and Andrographolide Combination on Carrageenan-Induced Paw Edema and Hyperalgesia in Rats

Effect of Diclofenac and Andrographolide Combination on Carrageenan-Induced Paw Edema and Hyperalgesia in Rats

Andrographolide protects chondrocytes from oxidative stress injury by activation of the Keap1–Nrf2–Are signaling pathway

Optimization and characterization of hepatoprotective andrographolide microspheres in the necrotic rat model

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