Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-κB and JAK-STAT signaling pathway

Ding, Yi; Chen, Lizhu; Wu, Wenjiao; Yang, Jie; Yang, Zifeng; Liu, Shuwen

doi:10.1016/j.micinf.2017.08.009

Cited by 91 publications

(57 citation statements)

References 44 publications

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“…Andrographolide (Andro) is one of the major bioactive components from a Chinese herbal medicine, Andrographis paniculata Nees [ 14 ]. Reports have shown that Andro exhibits a variety of biological activities, such as hepatoprotective [ 14 ], anti-inflammatory [ 15 ], antiviral [ 16 ], antitumor [ 17 ], antihyperglycemic [ 18 , 19 ], and antioxidant properties [ 20 ]. Recently, a study by Ji et al [ 21 ] reported that Andro treatment markedly attenuated ROS production and proinflammatory cytokines in the diabetic kidney.…”

Section: Introductionmentioning

confidence: 99%

Andrographolide Ameliorates Diabetic Cardiomyopathy in Mice by Blockage of Oxidative Damage and NF‐κB‐Mediated Inflammation

Liang

Lü

et al. 2018

Oxidative Medicine and Cellular Longevity

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Andrographolide (Andro), a major bioactive component obtained from Andrographis paniculata Nees, has exerted wide antioxidant as well as cytoprotective properties. However, whether Andro treatment could retard the progress of diabetic cardiomyopathy (DCM) remains unknown. In this study, we evaluated the effects of Andro against diabetes-induced myocardial dysfunction and explored the underlying mechanism in STZ-induced diabetic mice. As a result, treatment with Andro dose dependently suppressed cardiac inflammation and oxidative stress, accompanied by decreasing cardiac apoptosis, which subsequently ameliorated cardiac fibrosis and cardiac hypertrophy. Further, Andro blocked hyperglycemia-triggered reactive oxygen species (ROS) generation by suppressing NADPH oxidase (NOX) activation and augmenting nuclear factor erythroid 2-related factor 2 (Nrf2) expression both in vitro and in vivo. Our results suggest that the cardioprotective effects afforded by Andro treatment involve the modulation of NOX/Nrf2-mediated oxidative stress and NF-κB-mediated inflammation. The present study unravels the therapeutic potential of Andro in the treatment of DCM by attenuating oxidative stress, inflammation, and apoptosis.

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Section: Introductionmentioning

confidence: 99%

Andrographolide Ameliorates Diabetic Cardiomyopathy in Mice by Blockage of Oxidative Damage and NF‐κB‐Mediated Inflammation

Liang

Lü

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Andrographolide, a bicyclic diterpenoid lactone, is a major bioactive constituent of Andrographis paniculata, and has been shown to have activity against a number of viruses including DENV [16][17][18][19][20][21][22][23][29][30][31]. Given the close relationship between DENV and ZIKV, which belong to the same genus, it seems reasonable to expect that andrographolide would have antiviral activity against ZIKV, as was Figure 6.…”

Section: Discussionmentioning

confidence: 91%

“…F.] Nees, an herb known as a "natural antibiotic", is commonly used in China, India and Southeast Asia for the treatment of a large variety of illnesses including fever, inflammation and infection [15]. Andrographolide (Scheme 1), a bicyclic diterpenoid lactone, is one of the major components isolated from A. paniculata and andrographolide has been shown to have activity against a variety of viruses, including both RNA [16][17][18][19][20] and DNA [21][22][23] viruses. In particular, andrographolide has been shown to have good antiviral activity against DENV, with a half maximal effective concentration (EC 50 ) of 21 to 22 µM, depending upon cell type [18].…”

Section: Introductionmentioning

confidence: 99%

Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection

Khanom

Sun

et al. 2020

Molecules

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Andrographolide is a labdene diterpenoid with potential applications against a number of viruses, including the mosquito-transmitted dengue virus (DENV). In this study, we evaluated the anti-viral activity of three 14-aryloxy analogues (ZAD-1 to ZAD-3) of andrographolide against Zika virus (ZIKV) and DENV. Interestingly, one analogue, ZAD-1, showed better activity against both ZIKV and DENV than the parental andrographolide. A two-dimension (2D) proteomic analysis of human A549 cells treated with ZAD-1 compared to cells treated with andrographolide identified four differentially expressed proteins (heat shock 70 kDa protein 1 (HSPA1A), phosphoglycerate kinase 1 (PGK1), transketolase (TKT) and GTP-binding nuclear protein Ran (Ran)). Western blot analysis confirmed that ZAD-1 treatment downregulated expression of HSPA1A and upregulated expression of PGK1 as compared to andrographolide treatment. These results suggest that 14-aryloxy analogues of andrographolide have the potential for further development as anti-DENV and anti-ZIKV agents.

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“…Previous studies have characterized ADO as a strong plant-derived immunomodulator that affects the NF-κB and JAK-STAT signaling pathways, which are involved in host innate immune responses ( Ding et al, 2017 ). Therefore, we next measured endogenous mRNA levels of interferon-β (IFN-β) and an interferon-stimulated gene ISG56 at 0, 2, 4, 8, and 12 h post-infection ( Figures 4A,B ).…”

Section: Resultsmentioning

confidence: 99%

Andrographolide Prevents EV-D68 Replication by Inhibiting the Acidification of Virus-Containing Endocytic Vesicles

et al. 2018

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Enterovirus D68 (EV-D68) has emerged as a significant respiratory pathogen that can cause severe respiratory disease and acute neurologic disease. At present, there are no approved antiviral agents or vaccines for EV-D68. In this study, we demonstrate that andrographolide (ADO), an active component of Andrographis paniculata, exerts substantial antiviral activity against EV-D68 infection. ADO treatment dramatically inhibited EV-D68 RNA replication (EC50 = 3.45 μM) and protein synthesis without producing significant cytotoxicity at virucidal concentrations. ADO-treated cells did not show any changes in host immune activation, EV-D68 attachment, or viral 5′ UTR activity. Using a pH-sensitive fluorescent indicator system for endocytosis in living cells, we found that ADO prevented the acidification of endocytic vesicles after receptor-mediated endocytosis. Finally, we showed that ADO inhibited the viral replication of circulating isolated EV-D68 strains. In summary, our results demonstrate that ADO suppresses EV-D68 replication by targeting the maturation of virus-containing endosomes of EV-D68. This mechanism represents a promising strategy for drug development.

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Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-κB and JAK-STAT signaling pathway

Cited by 91 publications

References 44 publications

Andrographolide Ameliorates Diabetic Cardiomyopathy in Mice by Blockage of Oxidative Damage and NF‐κB‐Mediated Inflammation

Andrographolide Ameliorates Diabetic Cardiomyopathy in Mice by Blockage of Oxidative Damage and NF‐κB‐Mediated Inflammation

Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection

Andrographolide Prevents EV-D68 Replication by Inhibiting the Acidification of Virus-Containing Endocytic Vesicles

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