Anemia and iron deficiency: effects on pregnancy outcome

Allen, Lindsay H.

doi:10.1093/ajcn/71.5.1280s

Cited by 900 publications

(751 citation statements)

References 38 publications

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“…Birth weight is affected by many factors besides maternal Hb status, including the gender of an infant, maternal age, maternal body weight, smoking and alcohol consumption (Allen, 2000;King, 2000). In our present study, logistic regression analysis with low birth weight as the dependent variable showed that serum albumin and Hb level were significantly contributing to low birth weight.…”

Section: Discussionsupporting

confidence: 52%

“…At least 50% of the anemia has been attributed to iron deficiency (DeMaeyer and Adiels-Tegman, 1985;Singh et al, 1998). Maternal iron deficiency anemia increases the risk of premature delivery and subsequent low birth weight, and may contribute to low iron status and poor health of infants (Allen, 2000;Scholl and Reilly, 2000;Kaiser and Allen, 2002). Also, pregnant women with anemia are at a greater risk of perinatal mortality and morbidity (Haas and Brownlie, 2001;Rasmussen, 2001;Ramakrishnan and Yip, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Iron status and its association with pregnancy outcome in Korean pregnant women

Lee¹,

Kim

et al. 2006

Eur J Clin Nutr

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Objective: The purpose of this study was to assess the prevalence of iron deficiency anemia among Korean pregnant women and to assess the association between maternal hemoglobin (Hb) level and pregnancy outcome. Design: A longitudinal study. Setting: Ewha Womans University Hospital, Seoul, Korea. Subjects: A total of 248 normal pregnant women of 24-28 weeks gestation and 190 babies born to the pregnant subjects. Methods: Maternal anthropometry, blood parameters and pregnancy outcomes were measured. Results: Mean Hb, serum iron concentration, transferrin saturation and total iron binding capacity of the subjects were 11.4 g/dl, 89.4 mg/dl, 18.7% and 484.6 mg/dl, respectively, and 30.2% of the subjects were anemic judged by Hb concentration of o10.5g/dl. When subjects were classified into tertile groups based on Hb levels, the lowest tertile (HbT1) group had significantly lower concentrations of cord serum iron and albumin than those in the highest tertile (HbT3) group. Newborn infants from the HbT1 group had significantly higher rates of preterm delivery, low birth weight and low Apgar scores than those in other groups. Logistic regression analysis showed that maternal serum albumin and Hb level were the most important predictive variables for low birth weight. Conclusions: A substantial proportion of Korean pregnant women were at risk of anemia. Infants born to women with a low Hb level showed a lower birth weight, height and Apgar scores.

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Section: Discussionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Iron status and its association with pregnancy outcome in Korean pregnant women

Lee¹,

Kim

et al. 2006

Eur J Clin Nutr

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“…4 In fact, the provision of iron supplements to pregnant women is one of the most widely practiced public health measures. 5 However, there is no consensus worldwide regarding the optimum iron dose for supplementation during pregnancy, with recommendations varying between 30 to 200 mg/day. 6 Recommendations not only vary by iron dose, but also by whether iron supplementation is routine (treatment of all pregnant women regardless of their iron status) or selective (only women with or at risk of developing ID or IDA), and by whether guidelines include specific doses for prevention versus treatment of anaemia and/or ID.…”

Section: Introductionmentioning

confidence: 99%

Iron supplement use in pregnancy – Are the right women taking the right amount?

et al. 2016

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“…The prevalence of pregnant women suffering from iron de®ciency with or without anemia is reported to be as high as 40 ± 90% . A number of studies have indicated that iron de®ciency anemia during pregnancy may be associated with an increased cases of prematurity and perinatal mortality (Lops et al, 1995;Allen, 2000;Rush, 2000;Yip, 2000). However, how iron de®ciency in pregnant women affects the iron metabolism and iron status of their fetuses remains to be established.…”

Section: Introductionmentioning

confidence: 99%

Expression of ferritin receptor in placental microvilli membrane in pregnant women with different iron status at mid-term gestation

et al. 2001

Eur J Clin Nutr

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Objective: The effect of iron status in pregnant women on expression of ferritin receptor in placental microvilli membrane at mid-term gestation was investigated. Design: Ferritin receptor binding sites and dissociation constants (K d ) were determined in specimens of placental microvilli from 30 pregnant women at mid-term gestation and six women at term-delivery. Results: The ferritin receptor binding sites in the placental microvilli membrane in pregnant women with mild iron de®ciency and moderate iron de®ciency anemia were signi®cantly higher then those in pregnant women with normal iron status. However, no signi®cant difference was found between pregnant women with severe iron de®ciency anemia and with normal measurements. No signi®cant differences of K d values were detected between pregnant women with normal iron status and those with iron-de®ciency. Data also revealed that the ferritin receptor binding sites in placental microvilli membrane and K d values at mid-term gestation did not differ signi®cantly from those at term gestation. Conclusion: Lower iron status in pregnant women could lead to an increase in expression of ferritin receptor in placental microvilli membrane at mid-term gestation while the dissociation constant of ferritin receptor remains unchanged. This implies that the regulation of maternal ± fetal iron homeostasis via the ferritin receptor-mediated pathway is achieved by changes in the numbers of ferritin receptors rather then binding properties. Sponsorship: China Natural Science Foundation and The Hong Kong Polytechnic University. Descriptors: ferritin receptor; placental microvilli; iron status; pregnant women; maternal-fetal iron homeostasis

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Anemia and iron deficiency: effects on pregnancy outcome

Cited by 900 publications

References 38 publications

Iron status and its association with pregnancy outcome in Korean pregnant women

Iron status and its association with pregnancy outcome in Korean pregnant women

Iron supplement use in pregnancy – Are the right women taking the right amount?

Expression of ferritin receptor in placental microvilli membrane in pregnant women with different iron status at mid-term gestation

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