Anemia is related to osteoporosis in Chinese type 2 diabetic patients

Cui, Ran; Zhao, Zheng Shan; Fei, Zhaoliang; Li, Yinghua; Gao, Wenxue

doi:10.1007/s11657-021-01030-4

Cited by 8 publications

(10 citation statements)

References 27 publications

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“…33 Low levels of MCH or MCHC suggest anemia, 35,36 and anemia patients should be alert to osteoporosis. 37,38 It can be seen that people with low levels of UC MCH or MCHC are more likely to develop osteoporosis. Combined with the results of this study, we speculated that homozygous or heterozygous mutations of IL-10-rs1554286, -rs1518111, -rs3024490, and -rs1800871 may affect the level of UC, MCH, or MCHC and thus affect the susceptibility of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

Risk Genetic Variants (IL-10) for Osteoporosis in Han Population from Northwest China

Rong¹,

Lee²,

Zhou³

et al. 2023

JIR

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Background: Osteoporosis (OP) is a common metabolic bone disease characterized by loss of bone mass. IL-10 is considered to be a powerful immune and inflammatory suppressor. This study aimed to assess association between genetic loci in IL-10 and susceptibility to OP. Methods: Association analysis between IL-10 genetic loci and OP risk through SNPStats online software. FPRP analysis (falsepositive report probability) verified whether the positive results were noteworthy findings. Linkage disequilibrium (LD) and haplotype analysis were completed by Haploview 4.2 and SNPStats. Multi-factor dimensionality reduction (MDR) was used to assess interaction of SNP-SNP in susceptibility to OP.

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Section: Discussionmentioning

confidence: 99%

Risk Genetic Variants (IL-10) for Osteoporosis in Han Population from Northwest China

Rong¹,

Lee²,

Zhou³

et al. 2023

JIR

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“…A cross-sectional retrospective investigation revealed that men and women with the lowest hemoglobin levels had a higher incidence of osteoporosis. And BMD was also associated with both male and female hemoglobin levels ( 40 ). They warn diabetics with anemia (men with hemoglobin below 120 g/L and women with hemoglobin below 110 g/L) to be cautious of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

HemoglobinA1c Is a Risk Factor for Changes of Bone Mineral Density: A Mendelian Randomization Study

Hong

et al. 2022

Front. Endocrinol.

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BackgroundAs a valuable blood glucose measurement, HemoglobinA1c (HbA1c) is of great clinical value for diabetes. However, in previous observational studies, studies on its effect on bone mineral density (BMD) have different results. This study aimed to use Mendelian randomization (MR) to assess the effect of HbA1c on bone mineral density and fracture risk, and try to further explore whether this association was achieved through glycemic or non-glycemic factors.MethodsTake HbA1c measurement as exposure, and BMD estimated from quantitative heel ultrasounds (eBMD) and bone fractures as outcomes. Two-Sample MR Analysis was conducted to assess the causal effect of HbA1C on heel BMD and risk fracture. Then, we performed the analysis using two subsets of these variants, one related to glycemic measurement and the other to erythrocyte indices.ResultsGenetically increased HbA1C was associated with the lower heel eBMD [odds ratio (OR) 0.91 (95% CI 0.87, 0.96) per %-unit, P = 3 × 10−4(IVW)]. Higher HbA1C was associated with lower heel eBMD when using only erythrocytic variants [OR 0.87 (0.82, 0.93), P=2× 10−5(IVW)]; However, when using only glycemic variants, this casual association does not hold. In further MR analysis, we test the association of erythrocytic traits with heel eBMD.ConclusionOur study revealed the significant causal effect of HbA1c on eBMD, and this causal link might achieve through non-glycemic pathways (erythrocytic indices).

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“…A retrospective study in Taiwan also found that anemia were related to lower BMD and a higher percentage of osteoporosis in T2DM patients. 32 But the study was only performed in men above 50 years of age and postmenopausal women. Our study included a broader age range of patients aged 30–95 years with T2DM, and performed age-stratified analyses.…”

Section: Discussionmentioning

confidence: 99%

Association Between Hemoglobin Levels and Osteoporosis in Chinese Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

Ye¹,

Lu²,

Guo³

et al. 2022

DMSO

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Purpose To explore the relationship between hemoglobin levels and osteoporosis and the risk factors for osteoporosis in patients with type 2 diabetes mellitus (T2DM). Patients and methods A cross-sectional study was conducted in 495 T2DM adults. Medical data were collected from electronic medical records. Results T2DM patients with osteoporosis had significant lower hemoglobin levels (P < 0.001). Spearman correlation analysis and logistic regression analysis showed that age, female, body mass index (BMI), smoking, drinking and hemoglobin levels were significantly associated with osteoporosis in T2DM patients (all P < 0.05). After adjustment for BMI, diabetic duration, estimated glomerular filtration rate (eGFR), smoking and drinking, a significant association between hemoglobin levels and osteoporosis was observed in T2DM males aged 50 years and older (odds ratio [OR] = 0.978, 95% confidence interval [CI]: 0.958–0.998, P = 0.030). Compared to Q3 groups with normal hemoglobin levels, Q1 groups with anemia had an odd of osteoporosis increased 2.9-fold in T2DM men after adjustment for age, BMI, diabetic duration, eGFR, smoking and drinking (P = 0.032). Conclusion Hemoglobin levels were associated with the presence of osteoporosis in T2DM men, especially in those aged 50 years and older.

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Anemia is related to osteoporosis in Chinese type 2 diabetic patients

Cited by 8 publications

References 27 publications

Risk Genetic Variants (IL-10) for Osteoporosis in Han Population from Northwest China

Risk Genetic Variants (IL-10) for Osteoporosis in Han Population from Northwest China

HemoglobinA1c Is a Risk Factor for Changes of Bone Mineral Density: A Mendelian Randomization Study

Association Between Hemoglobin Levels and Osteoporosis in Chinese Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

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