Anencephaly alters renal parenchymal volume in human fetuses?

Diniz, André Luiz Lima; Sampaio, Francisco J.B.; Favorito, Luciano A.

doi:10.1590/s1677-5538.ibju.2020.06.02

Cited by 3 publications

(2 citation statements)

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“…Deep pelvic endometriosis is anatomically classified as anterior, middle, and posterior compartments. The anterior compartment is the region just posterior to the pubic symphysis, where endometrial implants may happen within the vesicouterine pouch, vesicovaginal septum, bladder, and ureter 24 . Panel et al 22 shows that patients with anterior compartment endometriosis had one or more abnormalities at urodynamic examination.…”

Section: Discussionmentioning

confidence: 99%

Changes in lower urinary tract function after minimally invasive nerve‐sparing for complete excision of endometriosis: An observational study

Gomes,

Fonseca,

Favorito

et al. 2024

Neurourology and Urodynamics

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ObjectivesThe objective of this paper is to evaluate changes in lower urinary tract symptoms (LUTS), severity of pain and urodynamic parameters after minimally invasive nerve‐sparing surgery for patients with endometriosis.MethodsWe analyzed 143 patients undergoing minimally invasive nerve‐sparing surgery for endometriosis excision (laparoscopy/robot‐assisted). The endometriosis was confirmed by preoperative clinical evaluation, magnetic resonance imaging (MRI) showing at least one lesion deeper than 5 mm, and histological confirmation after laparoscopy. We evaluated three points prior and after surgery: LUTS parameters according to the International Urogynecological Association; urodynamic measures of storage and voiding and the severity of the dyspareunia, dyschezia and dysmenorrhea assessed on a self‐reported 11‐point numeric rating scale. The Wilcoxon signed rank and McNemar tests were used for statistical analyses (p < 0.05).ResultsWe observed significant improvements in LUTS after the surgery with postoperative symptom‐free probabilities in urgency (64.5%), daytime frequency (38.5%), and dysuria (87.1%). However, slow stream prevalence increased significantly postsurgery (p = 0.022), with a 20.5% risk of asymptomatic patients developing this symptom. Urodynamic responses varied; for instance, maximum cystometric capacity improved significantly (p = 0.004), while postvoiding residual worsened (p = 0.006). Significant worsening in postvoiding residual occurred in women with normal preoperative values (p = 0.002), with a 17.7% risk of normal values becoming abnormal. Compliance or maximum cystometric capacity not considered normal preoperatively showed significant improvements (p < 0.001), but the risk of normal values becoming abnormal after surgery was 14.5%.ConclusionThe minimally invasive nerve‐sparing surgery for endometriosis excision shows improvement in lower urinary tract symptoms, urodynamics parameters and severity of pain. The majority of patients became asymptomatic in the postoperative period. When compared to the benefits of the patients' surgical treatment, particularly when considering the reduction of pain, the risks of the lower urinary tract treatment seem to be acceptable. The surgical intervention seems to be a safe alternative in patients with endometriosis, although studies with larger samples are needed to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Changes in lower urinary tract function after minimally invasive nerve‐sparing for complete excision of endometriosis: An observational study

Gomes,

Fonseca,

Favorito

et al. 2024

Neurourology and Urodynamics

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“…Recently, the urogenital tract of anencephalic fetuses has been studied, including the kidneys and collecting system [2,3], ureters [4], bladder [5], prostate [6,7], penis [8], testicles [9], female external genitalia [10] and vagina [11]. Some authors have indicated a different response of male and female anencephalic fetuses to hormonal stimulation [12].…”

Section: Introductionmentioning

confidence: 99%

Neural Tube Defects and Uterus Development in Human Fetuses

Diniz

Vieiralves

Sampaio

et al. 2022

Preprint

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Purpose: One of the most common malformations of the central nervous system is related to embryonic neural tube alterations. We hypothesized that anencephaly affects the development of the uterus during the human second trimester of pregnancy. The objective of this study was to study the biometric parameters of the uterus in fetuses with anencephaly and compare them with normocephalic fetuses at that important.Methods: In our study, 34 female fetuses were analyzed, 22 normal and 12 anencephalic, aged between 12 and 22 weeks post-conception (WPC). After dissection of the pelvis and individualization of the genital tract, we evaluated the length and width of the uterus using the Image J software. We compared the means statistically using the Wilcoxon-Mann-Whitney test and performed linear regression.Results: We do not identify statistical significance between the groups for the measurements of uterus length (Control: 2.02-6.36mm/mean=3.59mm/SD+-1.43 vs. Anencephalic: 1.71-5.44mm/mean=2.97mm/SD+-1.21, p=0.1070) and uterus width (Control: 1.99-7.91mm/mean= 3.84mm/SD+- 1.27 vs. Anencephalic: 2.08-6.48mm/mean= 3.65mm/SD +- 1.23; p =0.3360). The linear regression analysis indicated that 80% significance was found in the correlations in normocephalic fetuses (12.9 to 22.6 WPC) and 40% significance in anencephalic fetuses (12.3 to 18.6 WPC). Conclusions: We do not find statistical differences in the length and width of the uterus in anencephalic fetuses compared to the control group but uterine length and width shows a lesser tendency to growth in the anencephalic fetuses during the second trimester suggesting that anencephaly can impact the development of the uterus.

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Neural tube defects and uterus development in human fetuses

Diniz

Vieiralves

Sampaio

et al. 2022

Sci Rep

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One of the most common malformations of the central nervous system is related to embryonic neural tube alterations. We hypothesized that anencephaly affects the development of the uterus during the human second trimester of pregnancy. The objective of this study was to study the biometric parameters of the uterus in fetuses with anencephaly and compare them with normocephalic fetuses at that important. In our study, 34 female fetuses were analyzed, 22 normal and 12 anencephalic, aged between 12 and 22 weeks post-conception (WPC). After dissection of the pelvis and individualization of the genital tract, we evaluated the length and width of the uterus using the Image J software. We compared the means statistically using the Wilcoxon-Mann–Whitney test and performed linear regression. We identify significant differences between the uterus length (mm)/weight (g) × 100 (p = 0.0046) and uterus width (mm)/weight (g) × 100 (p = 0.0013) when we compared the control with the anencephalic group. The linear regression analysis indicated that 80% significance was found in the correlations in normocephalic fetuses (12.9 to 22.6 WPC) and 40% significance in anencephalic fetuses (12.3 to 18.6 WPC). The measurements of the uterus were greater in anencephalic group but there are no difference in the uterine width and length growth curves during the period studied. Further studies are required to support the hypothesis suggesting that anencephaly may affect uterine development during the human fetal period.

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Anencephaly alters renal parenchymal volume in human fetuses?

Cited by 3 publications

References 24 publications

Changes in lower urinary tract function after minimally invasive nerve‐sparing for complete excision of endometriosis: An observational study

Changes in lower urinary tract function after minimally invasive nerve‐sparing for complete excision of endometriosis: An observational study

Neural Tube Defects and Uterus Development in Human Fetuses

Neural tube defects and uterus development in human fetuses

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