Anesthesia Medications and Interaction with Chemotherapeutic Agents

Abstract

Cancer is now a leading health concern worldwide. In an effort to provide these patients with adequate care, coordination between anesthesiologists and surgeons is crucial. In cancer-related treatment, it is very clear that radiochemotherapy and medical procedures are important. There are some obstacles to anesthesia when dealing with cancer treatment, such as physiological disturbances, tumor-related symptoms, and toxicity in traditional chemotherapy treatment. Therefore, it is important that a multisystemic, multidisciplinary and patient-centered approach is used to preserve perioperative homeostasis and immune function integrity. Adding adjuvants can help increase patient safety and satisfaction and improve clinical efficacy. Correctly paired anesthetic procedures and medications will reduce perioperative inflammatory and immune changes that could potentially contribute to improved results for future cancer

Antitumorigenic Effect of Tramadol and Synergistic Effect With Doxorubicin in Human Breast Cancer Cells

“…The appropriate combination of surgical and anesthetic procedures and medications can reduce perioperative inflammatory and immune changes that could contribute to improved results for cancer patients. ( 33 )…”

“…The appropriate combination of surgical and anesthetic procedures and medications can reduce perioperative inflammatory and immune changes that could contribute to improved results for cancer patients. (33) The repurposing strategy of tramadol was applied to the development of therapy for breast cancer. The therapeutic blood levels of tramadol in adults range from 0.1 to 0.3 mg/L, the toxic level is between 1 and 2 mg/L, and the lethal concentration is higher than 2 mg/L.…”

Neutrophils and Anesthetic Drugs: Implications in Onco-Anesthesia

“…The interaction between anesthetic agents and anti-cancer drugs may be produced via an indirect mechanism of modulation of the host immune response and direct interference with cancer cell biology. The few mostly in vitro and animal model studies published so far showed that propofol may increase chemotherapeutic activity via the inhibition of Slug expression (increasing paclitaxel-induced apoptosis), abrogation of gemcitabineinduced DNA-binding activity of NF-kB, and downregulation of NF-kB [139,140]. However, there are studies showing that propofol may decrease chemotherapeutic efficiency via the inhibition of gap junction function [139][140][141].…”

“…Lidocaine may attenuate chemotherapeutic drug resistance or increase chemotherapeutic drug efficiency by decreasing the expression of miR-21 or via the downregulation of ABC transporter protein expression [139]. Animal model studies also showed that lidocaine decreased tumor proliferation and increased chemotherapeutic drug efficiency via the activation of caspase 3, decreased Bcl-2 and Bax expression, and the inactivation of ERK1/2 and p38 pathways [142].…”

Cardio-Oncologic Knowledge of Nurses in the Oncology Service: A Multi-Center Survey in China

“…Oncology patients are a special group of individuals with a low resistance to the effects of the disease and the treatment they are receiving, which results in physiological and psychological debilitation. 23 Chemotherapeutic drugs are a special kind of medication that is lethal also to normal tissue cells 24 and, therefore, require strict control of the drip rate and close observation of the patient's reaction to the drug. 25 The nurses should, therefore, be more precise in the nursing measures they undertake for the oncology patients who are infused with cardiotoxic drugs.…”