Anesthetic, Hypothermic, Myorelaxant and Anticonvulsant Effects of Synthetic Eugenol Derivatives and Natural Analogues

Dallmeier, Karolina; Carlini, E. A.

doi:10.1159/000137479

Cited by 119 publications

(71 citation statements)

References 12 publications

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“…Furthermore, in agreement with the mechanism of action of EOCn, 1,8-cineole was found to act by a non-opioid mechanism (18). Methyleugenol (19) and a-terpineol (20) have been reported to be central and peripheral neural depressants, respectively, which raises the suspicion that they might act as antinociceptive agents. For the other constituents we found no report in the literature on either antinociceptive or neural activity.…”

supporting

confidence: 62%

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

Abdon

Leal-Cardoso

Coelho‐de‐Souza

et al. 2002

Braz J Med Biol Res

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Croton nepetaefolius Baill. is an aromatic plant native to the northeast of Brazil where it is extensively used in folk medicine as a sedative, orexigen and antispasmodic agent. In the present study the antinociceptive effects of the essential oil of C. nepetaefolius (EOCn), administered orally, were evaluated in male Swiss mice (20-25 g). In the acetic acid-induced writhing test, EOCn (100 and 300 mg/kg; N = 14 and N = 12, respectively) was effective at the highest dose. In the hotplate test, EOCn at 30 and 300 mg/kg, but not at 3 mg/kg, significantly increased the latency at all observation times up to the 180th min (N = 12 for each dose). In the formalin test, EOCn significantly reduced paw licking in the second phase of the test at 100 mg/kg (N = 12), but decreased it in both phases at 300 mg/kg (N = 12). At 30 mg/kg, the effect of EOCn did not differ from control values in either phase of the formalin test (N = 6). Pretreatment with naloxone (5 mg/kg, ip) significantly reversed the analgesic effect of morphine (5 mg/kg, sc) on both phases, but not that of EOCn at 300 mg/kg (N = 6) on both phases of the formalin test. The data show that orally administered EOCn promotes a dose-dependent antinociceptive effect whose mechanisms remain to be elucidated.

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supporting

confidence: 62%

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

Abdon

Leal-Cardoso

Coelho‐de‐Souza

et al. 2002

Braz J Med Biol Res

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“…was used as the reference drug. Results were analyzed by repeated measures ANOVA followed by SNK (Dallmeier & Carlini, 1981).…”

Section: Hypothermic Effectsmentioning

confidence: 99%

Sedative effects of essential oils obtained fromBaccharis uncinella

Ascari

Sens²,

Nunes

et al. 2011

Pharmaceutical Biology

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“…Pharmacological studies show that eugenol demonstrated anesthetic, hypothermic, muscle-relaxant, anti-stress, and anticonvulsant activities (Dallmeier & Carlini, 1981).…”

Section: Chemical Compositions Of Essential Oilmentioning

confidence: 99%

Chemical composition and biological activities of essential oil ofBeilschmiedia pulverulenta

Salleh

Ahmad

Khong

et al. 2015

Pharmaceutical Biology

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Context: The ethnopharmacological study of Beilschmiedia indicates that several species are used for the treatment of various ailments. Objective: This is the first study of the chemical composition of Beilschmiedia pulverulenta Kosterm (Lauraceae) essential oil and its antioxidant, antimicrobial, antityrosinase, antiinflammatory, and anticholinesterase activities. Materials and methods: The antioxidant activities were evaluated by b-carotene, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, ferric-reducing antioxidant power (FRAP), and phenolic content at different concentrations. The antimicrobial activities against Gram-positive and Gram-negative bacteria and fungi were revealed by disk diffusion and microdilution. The antityrosinase and anti-inflammatory activities were assayed against mushroom tyrosinase and lipoxygenase enzymes. The anticholinesterase activity was analyzed using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Results: Forty-two components were detected in B. pulverulenta oil with eugenol (45.3%) being the major component. The oil phenolic content and the FRAP were 660.1 mg gallic acid/g and 604.0 mg ascorbic acid/g, respectively. The oil gave an IC 50 value of 94.5 mg/mL and an inhibition of 93.9% in DPPH and b-carotene, respectively. The antimicrobial activity showed that the oil had strong activity against all Gram-positive bacteria with an minimum inhibitory concentration (MIC) value each of 62.5 mg/mL and moderate against all fungi with MIC and minimum bactericidal concentration (MBC) values each of 125 mg/mL. The oil showed significant antityrosinase and anti-inflammatory activities with 67.6 and 62.5% inhibition, respectively. In addition, the oil had moderate AChE (56.5%) and BChE (48.2%) activities. Discussion and conclusion: The results show that the oil could potentially be used for nutraceutical industries, food manufactures, and therapeutic agents against various diseases such as inflammation and rheumatism.

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Anesthetic, Hypothermic, Myorelaxant and Anticonvulsant Effects of Synthetic Eugenol Derivatives and Natural Analogues

Cited by 119 publications

References 12 publications

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

Antinociceptive effects of the essential oil of Croton nepetaefolius on mice

Sedative effects of essential oils obtained fromBaccharis uncinella

Chemical composition and biological activities of essential oil ofBeilschmiedia pulverulenta

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