Aneuploidy in Man and Mechanisms of Nondisjunction Inferred from Studying Djungarian Hamster Oocytes

Hansmann, I.; Beermann, Friedrich; Hummler, Edith; Theuring, Franz

doi:10.1007/978-3-662-10621-1_12

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1998

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Cited by 4 publications

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“…Direct evidence that maternal meiosis may be disturbed by exogenous factors at the time of conception remains a matter of controversy, as does the postulated effect of preconceptional x irradiation or viral infections 3, 31. Recently a convincing correlation between the accidental ingestion of metriphonate (employed against fish parasites) at around the time of conception and trisomy 21 has been reported 32.…”

Section: Discussionmentioning

confidence: 99%

Significant increase in trisomy 21 in Berlin nine months after the Chernobyl reactor accident: temporal correlation or causal relation?

Sperling

Pelz

Wegner

et al. 1994

BMJ

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On the basis of two assumptions--(a) that maternal meiosis is an error prone process susceptible to exogenous factors at the time of conception; (b) that owing to the high prevalence of iodine deficiency in Berlin a large amount of iodine-131 would have been accumulated over a short period--it is concluded that the increased prevalence of trisomy 21 in West Berlin in January 1987 was causally related to a short period of exposure to ionising radiation as a result of the Chernobyl reactor accident.

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Section: Discussionmentioning

confidence: 99%