Aneurysmal bone cysts.A clinicopathological study of 105 cases

Abstract

A clinicopathological review of 105 cases of aneurysmal bone cyst is reported. Age and sex distribution and localization were in agreement with two previously reported large series. Recurrence occurred in 30.5% of all the cases and in 34.2% of those treated by curettage. Proved incompleteness of surgical removal was an important factor in recurrence (12 out of 17 cases or 70.6%). The recurrence rate was significantly (P2 less than 0.01) higher in cases with a mitotic index of seven or more per 50 fields (X 750) than in those with a lower mitotic index. In relation to the recurrence rate, no statistically significant differences were found between the age groups less than or equal to 15 and greater than 15 years, between the combination age and lesion size, or between four localization groups. The cyst wall and the septa consist of a superficial layer of cellular fibroblastic and histiocytic tissue in which multinuclear giant cells are present, covering a deeper situated zone of less cellular fibrous tissue. This typical layered architecture was found at one or more places in 93 (88.6%) out of 105 cases. However, layered architecture may also be found in cases of teleangiectatic osteosarcoma. It is suggested that the group with a high risk of recurrence be treated more radically, i.e., with cryosurgery.

Sclerotherapy in aneurysmal bone cysts in children: a review of 17 cases

“…Pathological material was obtained at the time of attempted surgical excision in six cases (patients 1, 3,5,7,12,13), and after surgical biopsy because of atypical radiological presentation in three cases (patients 8,11,14). According to pathology, one ABC was associated with ossifying fibromas (patient 7) and one with a unicameral bone cyst (patient 12).…”

Expression of Insulin-Like Growth Factor-I (IGF-I) in Aneurysmal Bone Cyst

“…Although the incidence of ABC is reported to be only 0.14 per 100.000 (2), since 1966, nearly 1000 articles have been published on this topic. The nature of ABC, however, has still remained unclear and controversial (3)(4)(5)(6)(7)(8), even leading Vicenzi to the conclusion that none of the present etiopathogenic theories is based on objective and convincing data (9). Most recently, Sciot et al reported chromosomal aberrations in ABC suggesting that at least some ABCs are true neoplasms (10).…”

Aneurysmal bone cysts: imaging findings and embolotherapy

“…[1 ]. There is general agreement that the aneurysmal bone cyst is a benign, nonneoplastic disorder, although the exact pathogenesis and cause continue to be debated.…”