2012
DOI: 10.1016/j.freeradbiomed.2012.10.548
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Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin

Abstract: Plasma hemoglobin (Hb) released during intravascular hemolysis has been associated with numerous deleterious effects that may stem from increased nitric oxide (NO) scavenging, but has also been associated with reactive oxygen species generation and platelet activation. Therapies that convert plasma oxyHb to metHb, or metHb to iron-nitrosyl Hb, could be beneficial because these species do not scavenge NO. In this study, we investigated the effects of Angeli’s Salt (AS, sodium α-oxyhyponitrite, Na2N2O3), a nitro… Show more

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Cited by 15 publications
(14 citation statements)
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References 55 publications
(64 reference statements)
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“…A 96-well plate reader (Molecular Devices, Softmax pro and Synergy H1, Gen5) and software were used for platelet aggregation measurements. [35,36] …”
Section: Methodsmentioning
confidence: 99%
“…A 96-well plate reader (Molecular Devices, Softmax pro and Synergy H1, Gen5) and software were used for platelet aggregation measurements. [35,36] …”
Section: Methodsmentioning
confidence: 99%
“…57,58 Commercial nylon 6/6 (Mw ~ 262.35 g/mol, Sigma Aldrich) was used as the polymer in the present study. Formic acid and acetic acid were used as-received.…”
Section: Methodsmentioning
confidence: 99%
“…Oxidation of cell-free Hb (which remains mainly in the oxygenated form in plasma) to metHb has been recognized as a potential treatment strategy to counter NO scavenging by plasma cell-free Hb [8,9497]. This strategy takes advantage of the fact that cell-free Hb reacts with NO on the order of 1000 times faster than red cell-encapsulated Hb, so that the cell-free Hb is preferentially oxidized while red cell metHb levels do not rise too high.…”
Section: Preservation By Mechanisms Involving Hb Oxidationmentioning
confidence: 99%