Communities have been exposed to the complications and problems caused by COVID‐19 disease, which has had various and complex effects on general health. The aim of this study was to investigate the relationship between anxiety, anger, mindfulness, and general health in the general population during the COVID‐19 outbreak in Iran. This cross‐sectional study was performed on 456 participants from September 2020 to April 2021. For data collection, Demographic Characteristics Form, General Health Questionnaire, Freiburg Mindfulness Inventory‐Short Form, The trait anxiety section of the State‐Trait Anxiety Inventory, The State‐Trait Anger Expression Inventory‐2 were used. General health was positively correlated with anxiety and anger and negatively correlated with mindfulness. Anxiety was positively correlated with anger and negatively correlated with mindfulness. No significant correlation was found between anger and mindfulness. Based on the multiple regression model, anxiety, anger and a family member infected with COVID‐19 were the predictors of general health (
p
< 0.001). Given that anxiety, anger, and family members infected with COVID‐19 are all predictors of public health, it is suggested that psychological programs and interventions be designed to reduce anxiety and anger, as well as to support family members infected with COVID‐19, to promote general health.