Angina in Coronary Artery Disease Patients With and Without Diabetes: <scp>US</scp> National Health and Nutrition Examination Survey 2001–2010

Hui, Gavin; Koch, Bruce; Calara, Federico; Wong, Nathan D.

doi:10.1002/clc.22488

Cited by 14 publications

(12 citation statements)

References 13 publications

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“…Prior reports have assessed the association between AP and physical activity, 8 showing that community-based adults with AP have significantly more limitations in Figure 3. Survival curve of time to incident angina by diabetes status.…”

Section: Discussionmentioning

confidence: 98%

“…6,7 Demographically, in patients with DM, AP has been reported to be more prevalent in women than men. 8,9 The relationship between type 2 DM, documented stable CHD, and AP symptoms in relation to all-cause and CVD mortality has been previously investigated using the results of the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. In patients with DM and stable CHD, a similar risk of all-cause mortality and CVD death has been demonstrated over 5 years of follow up in those with asymptomatic CHD compared to those with symptomatic CHD (i.e.…”

Section: Introductionmentioning

confidence: 99%

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Pre-diabetes, diabetes and predictors of incident angina among older women and men in the Cardiovascular Health Study

Mathenge

Fan

Wong

et al. 2019

Diabetes and Vascular Disease Research

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Diabetes mellitus and angina pectoris are important conditions in older persons. The utility of pre-diabetes mellitus, diabetes mellitus and other risk factors as predictors of incident angina pectoris among older adults has not been characterized. We examined incident angina pectoris rates by sex and diabetes mellitus status in 4511 adults aged ⩾65 years without coronary heart disease at baseline from the Cardiovascular Health Study. Cox regression examined predictors of incident angina pectoris, including pre-diabetes mellitus or diabetes mellitus adjusted for sociodemographic characteristics and other risk factors, over 12.2 ± 6.9 years of follow-up. Overall, 39.1% of participants had pre-diabetes mellitus, 14.0% had diabetes mellitus and 532 (11.8%) had incident angina pectoris. Incident angina pectoris rates per 1000 person-years in those with neither condition, pre-diabetes mellitus, and diabetes mellitus were 7.9, 9.0 and 12.3 in women and 10.3, 11.2 and 14.5 in men, respectively. Pre-diabetes mellitus and diabetes mellitus were not independently associated with incident AP; however, key predictors of AP were male sex, low-density lipoprotein-cholesterol, triglycerides, systolic blood pressure, antihypertensive medication and difficulty performing at least one instrumental activity of daily living (all p < 0.05 to p < 0.01). In our cohort of older adult participants, while the incidence of AP is greater in those with diabetes mellitus, neither diabetes mellitus nor pre-diabetes mellitus independently predicted incident angina pectoris.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Pre-diabetes, diabetes and predictors of incident angina among older women and men in the Cardiovascular Health Study

Mathenge

Fan

Wong

et al. 2019

Diabetes and Vascular Disease Research

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“…Ischemic heart disease is considered one of the major fatal events among adults ( 1 ). Patients with ischemic heart disease may experience referred pain in the head and neck areas.…”

Section: Discussionmentioning

confidence: 99%

“…Ischemic heart disease is considered as a major cause of death in adults ( 1 ). The cardinal symptom of ischemic heart disease is chest pain characteristically induced by activities such as walking, climbing stairs, eating, or stress.…”

Section: Introductionmentioning

confidence: 99%

Frequency of craniofacial pain in patients with ischemic heart disease

et al. 2016

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BackgroundReferred craniofacial pain of cardiac origin might be the only symptom of ischemic heart accidents. This study aimed to determine the frequency of craniofacial pain in patients with ischemic heart disease.Material and MethodsThis cross-sectional study was accomplished on 296 patients who met the criteria of having ischemic heart disease. Data regarding demographics, medical history and referred craniofacial pain were recorded in data forms. In addition, patients underwent oral examination to preclude any source of dental origin. Chi-square test, Student’s t-test and backward regression model were used to analyze the data by means of SPSS software version 21. P<0.05 was considered significant.ResultsA total of 296 patients were studied comprising of 211 men (71%) and 85 women (29%) with the mean age of 55.8. Craniofacial pain was experienced by 53 patients out of 296, 35 (66%) of whom were male and 18 (34%) were female. None of the patients experienced craniofacial pain solely. The most common sites of craniofacial pain were occipital and posterior neck (52.8%), head (43.3%), throat and anterior neck (41.5%) respectively. We found no relationship between craniofacial pain of cardiac origin with age, diabetes, hypertension, and family history. On the other hand, there was a significant relationship between hyperlipidemia and smoking with craniofacial pain of cardiac origin.ConclusionsRadiating pain to face and head can be expected quite commonly during a cardiac ischemic event. Dental practitioners should be thoroughly aware of this symptomatology to prevent misdirected dental treatment and delay of medical care. Key words:Craniofacial pain, ischemic heart disease, myocardial infarction, angina pectoris, referred pain.

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“…Despite aggressive use of traditional secondary prevention medications, nearly 50% of adults with both DM and CAD have chronic angina, and those with poorer glucose control are more likely to have severe angina (2). …”

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confidence: 99%

Ranolazine After Incomplete Percutaneous Coronary Revascularization in Patients With Versus Without Diabetes Mellitus

Wang

James

Weisz

et al. 2017

Journal of the American College of Cardiology

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BACKGROUND Chronic angina is more common in diabetes mellitus (DM) patients with poor glucose control. Ranolazine both treats chronic angina and improves glucose control. OBJECTIVES This study sought to examine ranolazine’s antianginal effect in relation to glucose control. METHODS We performed a secondary analysis of RIVER-PCI, a clinical trial in which 2,604 patients with chronic angina and incomplete revascularization following percutaneous coronary intervention (PCI) were randomized to ranolazine versus placebo. Mixed-effects models were used to compare the effects of ranolazine versus placebo on hemoglobin A1c (HbA1c) at 6 and 12 months of follow-up. Interaction between baseline HbA1c and ranolazine’s effect on Seattle Angina Questionnaire (SAQ) angina frequency at 6 and 12 months was tested. RESULTS Overall, 961 (36.9%) had DM at baseline. Compared with placebo, ranolazine significantly decreased HbA1c by 0.42±0.08% (adjusted mean difference ± standard error) and 0.44±0.08% from baseline to 6 and 12 months, respectively, in DM patients, and by 0.19±0.02% and 0.20±0.02% at 6 and 12 months, respectively, in non-DM patients. Compared with placebo, ranolazine significantly reduced SAQ angina frequency at 6 months among DM patients, but not at 12 months. The reductions in angina frequency were numerically greater among patients with baseline HbA1c ≥7.5% than those with HbA1c <7.5% (interaction p=0.07). CONCLUSIONS In patients with DM and chronic angina with incomplete revascularization after PCI, ranolazine’s effect on glucose control and angina at 6 months was proportionate to baseline HbA1C, but the effect on angina dissipated by 12 months.

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Angina in Coronary Artery Disease Patients With and Without Diabetes: US National Health and Nutrition Examination Survey 2001–2010

Cited by 14 publications

References 13 publications

Pre-diabetes, diabetes and predictors of incident angina among older women and men in the Cardiovascular Health Study

Pre-diabetes, diabetes and predictors of incident angina among older women and men in the Cardiovascular Health Study

Frequency of craniofacial pain in patients with ischemic heart disease

Ranolazine After Incomplete Percutaneous Coronary Revascularization in Patients With Versus Without Diabetes Mellitus

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