Pre-diabetes, diabetes and predictors of incident angina among older women and men in the Cardiovascular Health Study

Mathenge, Njambi; Fan, Wenjun; Wong, Nathan D.; Hirsch, Calvin H.; Delaney, Joseph A.; Amsterdam, Ezra A.; Koch, Bruce; Calara, Rico; Gardin, Julius M.

doi:10.1177/1479164119888476

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…In recent years, patients with impaired glucose tolerance and type 2 diabetes have tended to be younger [ 1 , 11 ]. Younger patients with impaired glucose tolerance and type 2 diabetes tend to have a poor prognosis and are associated with an increased risk of cardiovascular disease and microvascular complications [ 12 ]. The decline in the age of the initial onset of prediabetes and type 2 diabetes is unclear and complex.…”

Section: Introductionmentioning

confidence: 99%

Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data

Gong

Liu

Luo

et al. 2021

International Journal of Endocrinology

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Background. In the global chronic diseases, type 2 diabetes shows a significant upward trend, and there are more people before prediabetes (impaired glucose tolerance). Many patients with impaired glucose tolerance and undiagnosed diabetes do not know that their glucose metabolism system has been in a state of disorder. Every year, about 5% to 10% of prediabetics develop diabetes. One of the important achieving factors may be the increase in blood lipids. However, it is not clear whether the triglyceride/high-density lipoprotein ratio is associated with impaired glucose tolerance and diabetes in the Chinese population. Therefore, we investigated the relationship between triglyceride/high-density lipoprotein and impaired glucose tolerance and diabetes in the Chinese population. Methods. We conducted a retrospective cohort study using data from the health screening program. The study included 116,855 participants from 32 locations in China, all of whom were adults over 20. Participants measured fasting blood glucose levels at each visit and collected information about their diabetes history. Impaired glucose tolerance was diagnosed as fasting blood glucose ≥6.00 mmol and self-reported diabetes mellitus. The patient was measured on the date of diagnosis or on his last visit (whichever comes first). Results. The results showed that, after adjusting the potential confounding factors, the ratio of TG/HDL was positively correlated with the occurrence of prediabetes and diabetes, and there was a saturation effect. The inflection points were 1.04 and 1.33, respectively. The effect value and 95% confidence interval before and after the inflection point of impaired glucose tolerance patients were 1.57 and (1.42, 1.73) and 1.03 and (1.01, 1.05), respectively. The effect value and 95% confidence interval before and after the inflection point in patients with diabetes were 2.07 and (1.80, 2.39) and 1.08 and (1.04, 1.12).

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Section: Introductionmentioning

confidence: 99%

Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data

Gong

Liu

Luo

et al. 2021

International Journal of Endocrinology

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“…Sex differences were observed in global cognitive function (34,35) and in several cognitive domains (e.g., episodic memory and executive function) among older adults (36)(37)(38). Besides, sex differences were also overserved in CVD's prevalence or incidence (39)(40)(41), indicated by higher CVD in men. Middleaged and older Chinese have a much higher probability of abdominal obesity in men and more likely to meet the criteria of metabolic syndrome (42).…”

Section: Discussionmentioning

confidence: 96%

The Longitudinal Association Between Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study

Hua

Hou

Jiang

et al. 2020

Front. Cardiovasc. Med.

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Objective :China has the largest population living with dementia, causing a tremendous burden on the aging society. Cardiovascular disease (CVD) may trigger a cascade of pathologies associated with cognitive aging. We aim to investigate the association between cardiovascular risk (CVR) factors and cognitive function in the nationally representative cohort in China. Methods: Participants were recruited from 150 counties in 28 provinces via a four-stage sampling method. The outcomes included several cognitive tasks. The independent variable was a composite score of cardiovascular risk calculated from sex-specific equations. We fitted the time-lagged regression to model the association between CVR and cognition. Besides, we performed cross-group analyses to test for model invariance across sex and age. We thus constrained path coefficients to be equal across each grouping variable (e.g., sex) and compared the fit of this constrained model with an unconstrained model in which the path coefficients were allowed to vary by group. Results: A total of 3,799 participants were included in the final analyses. We found that the CVR had a negative linear association with global cognition (β = −0.1, p < 0.01). Additionally, CVR had inverse linear associations with domain-specific measurements of memory and learning, calculation, orientation, and visual-spatial ability (all values of p < 0.01). Regarding sex and age moderation, males had a more pronounced association between higher CVR and worse general cognition, immediate recall, orientation, calculation, and visual-spatial ability (all values of p < 0.0001).

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“…If subjects met any of the following criteria, they were excluded from the study:(1) not defined DM status at followup; (2) DM at baseline and follow-up; (3) body mass index (BMI) outliers (BMI>55 or <15 kg/m 2 ; (4) missing gender and weight, height, AST, ALT, fasting plasma glucose(FPG) values at baseline, and FPG during follow-up; (5) baseline FPG≥5.6mmol/ L and FPG>6.9mmol/L during follow-up; (6) follow-up interval less than two years; (7) those with AST/ALT ratio outliers (out of the range of means plus or minus three standard deviations). Finally, 75204 subjects eventually entered the study.…”

Section: Study Populationmentioning

confidence: 99%

“…In recent years, patients with impaired glucose tolerance and diabetes have shown a younger trend ( 5 , 6 ). A poor prognosis is common in young patients with impaired glucose tolerance and diabetes, and they are more likely to develop cardiovascular disease and microvascular complications ( 7 ). Moreover, lifestyle interventions could prevent 58% of prediabetic patients from developing DM, according to the Diabetes Prevention Program Research Group ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Nonlinear relationship between aspartate aminotransferase to alanine aminotransferase ratio and the risk of prediabetes: A retrospective study based on chinese adults

Cao¹,

Zhang²,

Yuan

et al. 2022

Front. Endocrinol.

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ObjectiveRecent evidence has revealed that the aspartate aminotransferase to alanine aminotransferase ratio (AST/ALT ratio) may be closely associated with metabolic syndrome and insulin resistance. However, it is unclear whether the AST/ALT ratio correlates with prediabetes risk. The aim of our study was to examine the association between AST/ALT ratios and the risk of prediabetes among a large cohort of Chinese subjects.MethodsThis retrospective cohort study recruited 75204 Chinese adults with normoglycemia at baseline who underwent physical examinations at the Rich Healthcare Group from 2010 to 2016. The AST/ALT ratio at baseline was the target independent variable, and the risk of developing prediabetes during follow-up was the dependent variable. Cox proportional-hazards regression was used to evaluate the independent association between the AST/ALT ratio and prediabetes. This study identified nonlinear relationships by applying a generalized additive model (GAM) and smooth curve fitting. In order to assess the robustness of this study, we performed a series of sensitivity analyses. Moreover, we performed a subgroup analysis to evaluate the consistency of the association in different subgroups. Data from this study have been updated on the DATADRYAD website.ResultsThe AST/ALT ratio was negatively and independently related to the prediabetes risk among Chinese adults (HR: 0.76, 95% CI: 0.75-0.84, P<0.0001) after adjusting demographic and biochemical covariates. Furthermore, a nonlinear relationship between the AST/ALT ratio and the risk of developing prediabetes was found at an inflection point of 1.50 for the AST/ALT ratio. When the AST/ALT ratio was to the left of the inflection point (AST/ALT ratio ≤ 1.50), the AST/ALT ratio was negatively related to the prediabetes risk (HR:0.70, 95%CI: 0.65-0.76, P<0.0001). In contrast, the relationship tended to be saturated when the AST/ALT ratio was more than 1.50 (HR: 1.01, 95%CI: 0.89-1.15, P=0.8976). Our findings remained robust across a range of sensitivity analyses. Subgroup analysis revealed that other variables did not alter the relationship between the AST/ALT ratio and prediabetes risk.ConclusionThis study revealed that AST/ALT ratio was negatively and independently associated with prediabetes risk among Chinese participants. The relationship between the AST/ALT ratio and prediabetes risk was nonlinear, and AST/ALT ratio ≤ 1.50 was strongly inversely correlated with prediabetes risk.

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Pre-diabetes, diabetes and predictors of incident angina among older women and men in the Cardiovascular Health Study

Cited by 4 publications

References 26 publications

Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data

Associations of TG/HDL Ratio with the Risk of Prediabetes and Diabetes in Chinese Adults: A Chinese Population Cohort Study Based on Open Data

The Longitudinal Association Between Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study

Nonlinear relationship between aspartate aminotransferase to alanine aminotransferase ratio and the risk of prediabetes: A retrospective study based on chinese adults

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