The Longitudinal Association Between Cardiovascular Risk and Cognitive Function in Middle-Aged and Older Adults in China: A Nationally Representative Cohort Study

Hua, Wei; Hou, Jianhua; Jiang, Taiyi; Su, Bin; Fu, Jiangning; Sun, Runsong; Chang, Biru; Xia, Wei; Wu, Hao; Zhang, Tong; Guo, Caiping; Wang, Wen

doi:10.3389/fcvm.2020.560947

Cited by 4 publications

(3 citation statements)

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“…Not only it is known to predict disability and mortality, 94 but also associations between cardiovascular risk factors and cognitive impairment have been reported from large cohort studies. 95 , 96 There is some evidence that small efforts to minimize several risk factors may prove as beneficial or more effective than substantial reduction in a single risk factor. 97 Ways to sustain the change over time include multi-disciplinary team engagement, and consideration of the social determinants of health, 97 to determine level of support required.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular disease risk communication and prevention: a meta-analysis

Bakhit,

Fien,

Abukmail

et al. 2024

European Heart Journal

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Background and Aims Knowledge of quantifiable cardiovascular disease (CVD) risk may improve health outcomes and trigger behavioural change in patients or clinicians. This review aimed to investigate the impact of CVD risk communication on patient-perceived CVD risk and changes in CVD risk factors. Methods PubMed, Embase, and PsycINFO databases were searched from inception to 6 June 2023, supplemented by citation analysis. Randomized trials that compared any CVD risk communication strategy versus usual care were included. Paired reviewers independently screened the identified records and extracted the data; disagreements were resolved by a third author. The primary outcome was the accuracy of risk perception. Secondary outcomes were clinician-reported changes in CVD risk, psychological responses, intention to modify lifestyle, and self-reported changes in risk factors and clinician prescribing of preventive medicines. Results Sixty-two trials were included. Accuracy of risk perception was higher among intervention participants (odds ratio = 2.31, 95% confidence interval = 1.63 to 3.27). A statistically significant improvement in overall CVD risk scores was found at 6–12 months (mean difference = −0.27, 95% confidence interval = −0.45 to −0.09). For primary prevention, risk communication significantly increased self-reported dietary modification (odds ratio = 1.50, 95% confidence interval = 1.21 to 1.86) with no increase in intention or actual changes in smoking cessation or physical activity. A significant impact on patients’ intention to start preventive medication was found for primary and secondary prevention, with changes at follow-up for the primary prevention group. Conclusions In this systematic review and meta-analysis, communicating CVD risk information, regardless of the method, reduced the overall risk factors and enhanced patients’ self-perceived risk. Communication of CVD risk to patients should be considered in routine consultations.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular disease risk communication and prevention: a meta-analysis

Bakhit,

Fien,

Abukmail

et al. 2024

European Heart Journal

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“…The same mechanism can cause more microvascular damage in women’s brains, resulting in quiet cerebral infarction and hypoperfusion. 34 37 In cohort study conducted in China, older subjects had more association between high cardiovascular risk and worse calculation ability. 37 …”

Section: Discussionmentioning

confidence: 99%

“… 34 37 In cohort study conducted in China, older subjects had more association between high cardiovascular risk and worse calculation ability. 37 …”

Section: Discussionmentioning

confidence: 99%

Associations Between Korean Coronary Heart Disease Risk Score and Cognitive Function in Dementia-Free Korean Older Adults

et al. 2023

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Background Cardiovascular risk is a modifiable factor that can help prevent dementia. Given the dearth of optimal treatment options, managing dementia risk factors is crucial. We examined the association between cardiovascular risk, as measured by the Korean coronary heart disease risk score (KRS), and cognitive function in dementia-free elderly individuals. Methods We enrolled 8,600 individuals (average age: 69.74 years; 5,206 women) who underwent a medical evaluation from the National Health Insurance Service. KRS was calculated using age, sex, blood pressure, lipid profile, diabetes, and smoking status. Cognitive function was evaluated using Korean Dementia Screening Questionnaire-Cognition (KDSQ-C). Scores of ≥ 6 indicated a cognitive decline. Logistic regression analysis was used to estimate the odds ratio (OR) and 95% confidence interval (CI). Weight, height, stroke history, coronary heart disease history, alcohol consumption, and physical activity engagement were adjusted. Results The lowest, middle, and highest groups, according to the KRS, were 5,923 (68.9%), 2,343 (27.2%), and 334 (3.9%), respectively. The highest KRS group in all participants exhibited a greater risk of cognitive decline than the lowest KRS group (OR, 1.339; 95% CI, 1.034–1.734; P = 0.027). The highest KRS female group aged 71–75 years old exhibited greater cognitive decline than the corresponding lowest KRS group (OR, 1.595; 95% CI, 1.045–2.434; P = 0.031). Conclusion Individuals with high cardiovascular risk were associated with poorer cognitive function than those with low risk, especially older women. Cardiovascular risk factors should be carefully managed to promote healthy mental aging in dementia-free elderly individuals.

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