Angiocentric glioma: Report of a rare case presenting with psychosis

Abstract

Angiocentric glioma (AG), first described in 2005, was included as a distinct entity in the 2007 World Health Organization Classification of Tumors of the Central Nervous System. It is a very rare cerebrocortical tumor mainly affecting children and young adults with a history of intractable partial seizures. The histopathological features of this entity are perivascular arrangement of monomorphic, bipolar spindled cells with subpial aggregation of tumor cells and variable neuroparenchymal colonization. Of uncertain histogenesis, this is a stable/slowly growing tumor. Prognosis following total surgical resection is favorable. We describe an AG in a 16-year-old, intellectually disabled, male patient, with psychosis. This is a rare presentation with only one such case in literature. Patient's symptoms ameliorated following surgery.

Awake Surgery for Angiocentric Glioma in the Eloquent Area in an Adolescent: A Case Report

“…They typically present in children and young adults (mean age, 17 years) with intractable partial seizures and equally affect patients of both sexes. Refractory epilepsy is the leading presentation, and is often drug-resistant [ 10 ]. The tumors are predominantly supratentorial and often seen superficially, showing a stalk-like extension to the adjacent lateral ventricle.…”

“…Surgery for AG is curative when gross total resection is achieved. In some cases with partial resection, the patients died or experienced recurrence [ 10 ]. In general, tumor removal is widely performed using motor and somatosensory evoked potentials in brain tumors that require preservation of motor function.…”