Psychiatric symptoms in children with low-grade glioma and craniopharyngioma: A systematic review

Sherman, Sarah J.; Tanaka, Ryuma; Qaddoumi, Ibrahim

doi:10.1016/j.jpsychires.2022.01.056

Cited by 9 publications

(3 citation statements)

References 108 publications

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“…In recent reports, the importance of brain tumors presenting as psychiatric conditions was emphasized; a major finding was the prevalence of hypothalamic tumors in patients with anorexia nervosa, prompting the authors to recommend neuroimaging for such patients [ 20 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Diencephalic Syndrome: Misleading Clinical Onset of Low-Grade Glioma

La Spina,

Caruso,

Gulizia

et al. 2023

Current Oncology

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Background: Diencephalic Syndrome is an atypical early manifestation of low-grade gliomas; so, it is important to detect it in patients that experience a failure to thrive despite adequate length growth and food intake. The purpose of this article is to focus attention on this rare but potentially dangerous cause of poor weight gain or stunting in childhood. Materials and Methods: We describe four patients with Diencephalic Syndrome and low-grade gliomas who were evaluated in our institution from January 2017 to December 2021. Case Description and Results: two patients presented with suspected malabsorption, and two presented with a suspected eating disorder. In all cases, neurological symptoms appeared late, explaining the reason for the diagnostic delay, which impacts negatively on prognosis and on quality of life. Currently, patients 1 and 2 have stable disease in second-line therapy, patient 3 has stable disease post end of second-line therapy, and patient 4 has stable disease in first-line therapy. Everyone is in psychophysical rehabilitation. Conclusions: A multidisciplinary evaluation is essential in order to make an early diagnosis and improve prognosis and quality of life.

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Section: Discussionmentioning

confidence: 99%

Diencephalic Syndrome: Misleading Clinical Onset of Low-Grade Glioma

La Spina,

Caruso,

Gulizia

et al. 2023

Current Oncology

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“…In about 30% [28] of the cases, optic pathways gliomas are associated with neurofibromatosis type 1, a genetic disorder that often also leads to further late complications such as inattention, visuospatial deficits, and mild intellectual disability which may affect academic performance [27,29,30]. Children treated for craniopharyngiomas are known to be at risk for behavioral changes, fatigue, and cognitive deficits that also may affect academic performance [31][32][33].Children treated for low-grade astrocytomas and neuronal and mixed neuronal-glial tumors have also been shown to be at risk for late complications [25,34]. Problems resulting from late complications often increase over time [4,35,36] and there is a high risk of difficulties during compulsory school [23,[37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Post-Compulsory Education in Teenagers and Young Adults Treated for Brain Tumors in Childhood: A Swedish Nationwide Registry-Based Study

Lönnerblad

Åberg

Blomgren

et al. 2022

Cancers

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The risk of late complications after a brain tumor in childhood is high. Both the tumor itself and the treatments give rise to sequelae that affect daily life activities. In this registry study, we explored post-compulsory education, i.e., further education following the nine compulsory years in school, in 452 cases born 1988–1996 and diagnosed with a brain tumor before their fifteenth birthday. They were compared with 2188 individual controls who were not treated for cancer. Significantly fewer teenagers and young adults treated for brain tumors in childhood attended high school or university compared with controls, especially individuals treated for embryonal tumors or optic pathway gliomas. A significantly larger proportion of subjects treated for embryonal tumors and craniopharyngiomas attended folk high schools, a type of post-compulsory school with a more accessible learning environment. For both cases and controls, we observed a positive correlation between parental education levels and attendance in high school and university. In our previous studies we have shown that children treated for brain tumors, as a group, tend to perform worse during their last year of compulsory school compared with their peers, and the current study confirms that these differences remain over time.

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“…1 Low-grade gliomas are a relatively common cause of epilepsy 2,3 but are less frequently associated with psychotic symptoms. [4][5][6][7] One schema for categorizing epilepsy-associated psychoses focuses on the temporal relationship of psychotic symptoms to seizures: ictal psychosis, postictal psychosis, and chronic interictal psychosis. 8 There may be bidirectionality to the symptomatology, as studies have suggested that people with epilepsy are at increased risk of developing schizophrenia, whereas people with schizophrenia have a higher prevalence of epilepsy than the general population.…”

mentioning

confidence: 99%

Improved psychotic symptoms following resection of amygdalar low-grade glioma: illustrative case

Andrews

Wozny

Yue

et al. 2022

Journal of Neurosurgery: Case Lessons

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BACKGROUND Epilepsy-associated psychoses are poorly understood, and management is focused on treating epilepsy. Chronic, interictal psychosis that persists despite seizure control is typically treated with antipsychotics. Whether resection of a mesial temporal lobe lesion may improve interictal psychotic symptoms that persist despite seizure control remains unknown. OBSERVATIONS In a 52-year-old man with well-controlled epilepsy and persistent comorbid psychosis, brain magnetic resonance imaging (MRI) revealed an infiltrative, intraaxial, T2 fluid-attenuated inversion recovery intense mass of the left amygdala. The patient received an amygdalectomy for oncological diagnosis and surgical treatment of a presumed low-grade glioma. Pathology was ganglioglioma, World Health Organization grade I. Postoperatively, the patient reported immediate resolution of auditory hallucinations. Patient has remained seizure-free on 2 antiepileptic drugs and no antipsychotic pharmacotherapy and reported lasting improvement in his psychotic symptoms. LESSONS This report discusses improvement of psychosis symptoms after resection of an amygdalar glioma, independent of seizure outcome. This case supports a role of the amygdala in psychopathology and suggests that low-grade gliomas of the limbic system may represent, at minimum, partially reversible etiology of psychotic symptoms.

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Psychiatric symptoms in children with low-grade glioma and craniopharyngioma: A systematic review

Cited by 9 publications

References 108 publications

Diencephalic Syndrome: Misleading Clinical Onset of Low-Grade Glioma

Diencephalic Syndrome: Misleading Clinical Onset of Low-Grade Glioma

Post-Compulsory Education in Teenagers and Young Adults Treated for Brain Tumors in Childhood: A Swedish Nationwide Registry-Based Study

Improved psychotic symptoms following resection of amygdalar low-grade glioma: illustrative case

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