Improved psychotic symptoms following resection of amygdalar low-grade glioma: illustrative case

Andrews, John P.; Wozny, Thomas A.; Yue, John K.; Wang, Doris D.

doi:10.3171/case22362

Cited by 4 publications

(1 citation statement)

References 30 publications

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“…In general, it is thought that psychiatric symptoms may not have any localizing value. [ 6 ] However, there is anecdotal evidence that brain tumors in the limbic system, such as the amygdala, might be associated with psychotic symptoms [ 19 , 20 ] and mood symptoms such as depression with frontal tumors [ 6 ]. One explanation for the found association in our study between psychiatric symptoms and non-frontal tumors could be that we excluded patients whit psychiatric symptoms at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Incidence of clinically relevant psychiatric symptoms during glioblastoma treatment: an exploratory study

et al. 2023

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Purpose In addition to neurological symptoms glioblastoma (GBM) patients can experience psychiatric complaints, which are often hard to recognize and difficult to treat. Research on psychiatric symptoms during glioblastoma treatment is limited, but can have significant impact on quality of life, treatment processes and even survival. The aim of this study is to explore the incidence of clinically relevant psychiatric symptoms, during glioblastoma treatment and active surveillance. Methods Medical records of 302 GBM patients were reviewed from diagnostic surgery until discontinuation of treatment or active surveillance. Clinical relevance was defined as psychiatric symptoms that interfered with the oncological treatment and required referral to a psychiatrist. “Referred” versus “non-referred” GBM patients were compared using the Pearson Chi-Square test, Fisher’s Exact Test or Mann Whitney-U test. Results Psychiatric symptoms occurred in 11.5% of patients during glioblastoma treatment or active surveillance, most often mood or behavioral symptoms, followed by psychotic symptoms. Referral occurred mainly during concomitant chemoradiation or adjuvant chemotherapy (64.3%). In 28.6% of patients psychiatric symptoms were thought to be attributive to medication. Treatment was discontinued in 17.9% of patients and temporarily interrupted in 3.6%. Possible risk factors included male gender, history of psychiatric disorder, postoperative delirium, non-frontal tumor location, anti-epileptic drug use at baseline and corticosteroid initiation during treatment. Conclusion The found incidence of 11.5% and the high number of patients discontinuing treatment due to psychiatric symptoms justify more research in this, to date, understudied topic in scientific literature. Further prospective studies are needed to identify risk factors and unravel possible effects on survival.

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Section: Discussionmentioning

confidence: 99%

Incidence of clinically relevant psychiatric symptoms during glioblastoma treatment: an exploratory study

et al. 2023

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Delirium and psychoses

Mohtashami,

Kocher,

Brownlowe

et al. 2024

Neuropsychological and Psychosocial Foundations of Neuro-Oncology

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Rare Neuronal, Glial and Glioneuronal Tumours in Adults

Crainic

Furtner

Pallud

et al. 2023

Cancers

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Rare glial, neuronal and glioneuronal tumours in adults form a heterogeneous group of rare, primary central nervous system tumours. These tumours, with a glial and/or neuronal component, are challenging in terms of diagnosis and therapeutic management. The novel classification of primary brain tumours published by the WHO in 2021 has significantly improved the diagnostic criteria of these entities. Indeed, diagnostic criteria are nowadays multimodal, including histological, immunohistochemical and molecular (i.e., genetic and methylomic). These integrated parameters have allowed the specification of already known tumours but also the identification of novel tumours for a better diagnosis.

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Improved psychotic symptoms following resection of amygdalar low-grade glioma: illustrative case

Cited by 4 publications

References 30 publications

Incidence of clinically relevant psychiatric symptoms during glioblastoma treatment: an exploratory study

Incidence of clinically relevant psychiatric symptoms during glioblastoma treatment: an exploratory study

Delirium and psychoses

Rare Neuronal, Glial and Glioneuronal Tumours in Adults

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