Angiogenesis and Anastomosis on Graft Retina after Autologous Retinal Transplantation

Kitahata, Shohei; Inoue, Maiko; Yanagi, Yasuo; Tanaka, Sanae; Inoue, Tatsuya; Yamakawa, Tadashi; Uchio, Eiichi; Kadonosono, Kazuaki

doi:10.1016/j.oret.2022.05.007

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…The occurrence of anastomosis between retinal and choroidal neovascularization in type 3 neovascularization and the macular capillary anastomosis observed between the host and graft retinas in macular hole patients with autologous retinal transplantation suggest that anastomosis in the eye may involve both pathological and physiological vessels, depending on the condition. 14,15 Thus, further studies are needed to verify the clinical relevance and consequences of anastomosis in our cases.…”

Section: Discussionmentioning

confidence: 95%

Reperfusion of retinal nonperfusion by neovascular-vascular anastomosis in proliferative diabetic retinopathy

Shiraki,

Tsuboi,

Wakabayashi

et al. 2023

European Journal of Ophthalmology

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Background Retinal nonperfusion is a significant cause of vision loss in patients with proliferative diabetic retinopathy (PDR). Therefore, reperfusion of a nonperfusion has been a matter of strong interest, but few previous studies have demonstrated the potential benefits of reperfusion. Case reports Here, we report longitudinal optical coherence tomography angiographic analysis of two cases of PDR, in which the retinal neovascularization (RNV) that developed in response to retinal ischemia formed anastomoses with pre-existing physiological retinal vessels, resulting in both superficial and deep capillary reperfusion within the nonperfusion. We named this interesting finding “neovascular-vascular anastomosis.” Retinal reperfusion due to neovascular-vascular anastomosis differed from recanalization, defined as reperfusion of once-occluded blood vessels, and has not been reported previously. Conclusion Our observation highlights the potential of RNV to rescue retinal ischemia by the formation of neovascular-vascular anastomoses.

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Section: Discussionmentioning

confidence: 95%