Angiogenesis in cancer

Nishida, Naoyo; Yano, Hirohisa; Nishida, Takashi; Kamura, Toshiharu; Kojiro, Masamichi

doi:10.2147/vhrm.2006.2.3.213

Cited by 1,221 publications

(788 citation statements)

References 95 publications

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“…43,44 Hypoxiainducible factor 1 (HIF-1) controls oxygen delivery (via angiogenesis) to cancer tissues. 45,46 Our previous data using hif-1adPA mice showed that hif-1a over-expression in hepatocytes led to increased steatosis, while hif-1a deletion in hepatocytes protected mice from alcohol-induced liver injury.…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10

et al. 2016

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Obesity-related inflammation promotes cancer development. Tissue resident macrophages affect tumor progression and the tumor micro-environment favors polarization into alternatively activated macrophages (M2) that facilitate tumor invasiveness. Here, we dissected the role of western diet-induced NASH in inducing macrophage polarization in a carcinogen initiated model of hepatocellular carcinoma (HCC). Adult C57BL/6 male mice received diethyl nitrosamine (DEN) followed by 24 weeks of high fat-high cholesterol-high sugar diet (HF-HC-HSD). We assessed liver MRI and histology, serum ALT, AFP, liver triglycerides, and cytokines. Macrophage polarization was determined by IL-12/TNFa (M1) and CD163/ CD206 (M2) expression using flow cytometry. Role of hif-1a-induced IL-10 was dissected in hepatocyte specific hif-1aKO and hif-1adPA (over-expression) mice. The western diet-induced features of NASH and accelerated HCC development after carcinogen exposure. Liver fibrosis and serum AFP were significantly increased in DEN C HF-HC-HSD mice compared to controls. Western diet resulted in macrophage (F4/ 80 C CD11b C ) infiltration to liver and DEN C HF-HC-HSD mice showed preferential increase in M2 macrophages. Isolated hepatocytes from western diet fed mice showed significant upregulation of the hypoxia-inducible transcription factor, hif-1a, and livers from hif-1a over-expressing mice had increased proportion of M2 macrophages. Primary hepatocytes from wild-type mice treated with DEN and palmitic acid in vitro showed activation of hif-1a and induction of IL-10, a M2 polarizing cytokine. IL-10 neutralization in hepatocyte-derived culture supernatant prevented M2 macrophage polarization and silencing hif-1a in macrophages blocked their M2 polarization. Therefore, our data demonstrate that NASH accelerates HCC progression via upregulation of hif-1a mediated IL-10 polarizing M2 macrophages.

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Section: Discussionmentioning

confidence: 99%

Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10

et al. 2016

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“…Further, the pro-angiogenesis activity of tumor cells becomes crucial for their survival in a microenvironment progressively more hypoxic, for a continuous supply of nutrients and oxygen [116]. The hypoxic TME triggers, also through oxidative stress −as shown in ovarian and prostate cancers [117][118][119], the tumor production of angiogenetic factors such as vascular-endothelial-growth-factor (VEGF), by upregulating hypoxia-inducible factor-1α (HIF-1α) [120]. Interestingly, HIF-1α is able to limit ROS accumulation in tumor cells, thus promoting cancer progression at later stages, by limiting the production of acetyl-CoA (the key molecule entering the TCA cycle) from glycolysis [121] and fattyacid oxidation [122].…”

Section: Mitochondrial Dynamics and Ros Production In Cancermentioning

confidence: 99%

The mitochondrial dynamics in cancer and immune-surveillance

Simula

Nazio

Campello

2017

Seminars in Cancer Biology

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A B S T R A C TMitochondria-shaping proteins control the dynamic equilibrium between fusion and fission of the mitochondrial network. Their balance is strictly required to regulate various processes, including the quality of mitochondria, cell metabolism, cell death, proliferation and cell migration. Alterations in these processes are frequently encountered in cancer, during both its onset and later progression, as evidence emerge connecting alterations in mitochondrial dynamics with cancer development. In recent years, novel therapeutic approaches to fight against different human tumors aim at exploiting the immune system's ability to specifically recognize tumor antigens, thus killing malignant cells in a process named immune-surveillance. Interestingly, data are accumulating on the role that mitochondrial dynamics play also for the correct function of both the innate and the adaptive immune system. By this review, we overview how mitochondrial dynamics can affect various processes during cancer development, acting directly on tumor cells or indirectly on cells responsible for tumor aggression and defence.

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“…These provide neoproliferation. Tumors may become necrotic without these substances, and hence sufficient vascular support is needed (7,8). These vascular networks, allowing the growth of benign tumors and the growth and metastasis of malignant tumors, can be blocked through various methods.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Internal Mammary Artery and Lateral Thoracic Artery Width in Patients with Benign and Malignant Breast Tumors

Arslan¹,

Çubuk²,

Çelìk³

et al. 2017

Erciyes Med J

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Objective: The main objective of this study was to analyze the differences in ipsilateral and contralateral internal mammary artery (IMA) and lateral thoracic artery (LTA) width in patients with malignant and benign breast tumor.Materials and Methods: A total of 104 female patients, of which 41 had benign and 63 had malignant tumors, were included in the study. The diameters of the IMA and LTA were measured from the widest point in T1-weighted post-contrast images. Breast magnetic resonance images were evaluated by a breast radiologist. Results:The ipsilateral IMA diameter of cases in the malignant group was found to be statistically significantly higher when compared with the benign group. In the benign group, the ipsilateral IMA diameter being an average of 0.43±0.87 mm larger than the contralateral IMA diameter was found to be statistically significant, whereas in the malignant cases, the ipsilateral IMA diameter being an average of 0.78±1.08 mm larger than the contralateral IMA diameter was found to be statistically significant. Also, in benign cases, the ipsilateral LTA diameter being an average of 0.31±0.70 mm larger than the contralateral LTA diameter was found to be statistically significant, whereas in malignant cases, the ipsilateral LTA diameter being an average of 0.29±0.68 mm larger than the contralateral LTA diameter was found to be statistically significant. Conclusion:The IMA and LTA diameters in benign and malignant cases were found to be higher in comparison with contralateral breast, independent of the size of the lesion.

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Angiogenesis in cancer

Cited by 1,221 publications

References 95 publications

Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10

Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1αinduced IL-10

The mitochondrial dynamics in cancer and immune-surveillance

Comparison of Internal Mammary Artery and Lateral Thoracic Artery Width in Patients with Benign and Malignant Breast Tumors

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