Angiogenesis in pancreatic carcinoma

Fujioka, Shozo; Yoshida, Kazuhiko; Yanagisawa, Satoru; Kawakami, Makio; Aoki, Teruaki; Yamazaki, Yoji

doi:10.1002/1097-0142(20011001)92:7<1788::aid-cncr1695>3.0.co;2-z

Cited by 84 publications

(21 citation statements)

References 41 publications

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13] Vermeulen et al 15 recommended CD 31 to stain the vessels. They noted that CD 31 was useful in breast cancer; however, was significantly lower than that of the group with a peripheral MVD count of less than 30 counts/mm 2 (dashed line; 8.6 months vs 26.6 months; P ϭ 0.0001).…”

Section: Discussionmentioning

confidence: 99%

“…In our preliminary study, CD 31 was not useful to clearly stain the vessels in pancreatic cancer. Fujioka et al 10 reported that IMD was related to overall and relapsefree survival, as examined by CD 34 in 104 patients with pancreatic carcinoma. However, we failed to stain microvessels, using CD 34, in all 41 patients.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11][12][13] The few studies on MVD in pancreatic cancer have reported only a limited association between MVD and liver metastasis or prognosis. [3][4][5][6][7][8][9][10] Recently, Fujioka et al 10 reported a close relation between intratumoral microvessel density (IMD) and overall relapse-free survival, using CD34 in 104 patients. Their report is meaningful; however, we failed to stain MVD with CD34.…”

Section: Introductionmentioning

confidence: 99%

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A high peripheral microvessel density count correlates with a poor prognosis in pancreatic cancer

2005

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A high peripheral microvessel density count correlates with a poor prognosis in pancreatic cancer

2005

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“…VEGF and MMP-9 have been identified as factors that stimulate pancreatic tumor angiogenesis [132,133,134]. Several studies have found a correlation between pro-angiogenic factors or intratumoral microvessel density and metastasis [135,136,137]. Cancer cell dissemination is increased in hypervascularized tumors, and extensive tumor vascularization is hence a hallmark of poor prognosis [135,137].…”

Section: Tumor Micro-environmentmentioning

confidence: 99%

Cancer Stem Cells, EMT, and Developmental Pathway Activation in Pancreatic Tumors

Hindriksen

Bijlsma

2012

Cancers

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Pancreatic cancer is a disease with remarkably poor patient survival rates. The frequent presence of metastases and profound chemoresistance pose a severe problem for the treatment of these tumors. Moreover, cross-talk between the tumor and the local micro-environment contributes to tumorigenicity, metastasis and chemoresistance. Compared to bulk tumor cells, cancer stem cells (CSC) have reduced sensitivity to chemotherapy. CSC are tumor cells with stem-like features that possess the ability to self-renew, but can also give rise to more differentiated progeny. CSC can be identified based on increased in vitro spheroid- or colony formation, enhanced in vivo tumor initiating potential, or expression of cell surface markers. Since CSC are thought to be required for the maintenance of a tumor cell population, these cells could possibly serve as a therapeutic target. There appears to be a causal relationship between CSC and epithelial-to-mesenchymal transition (EMT) in pancreatic tumors. The occurrence of EMT in pancreatic cancer cells is often accompanied by re-activation of developmental pathways, such as the Hedgehog, WNT, NOTCH, and Nodal/Activin pathways. Therapeutics based on CSC markers, EMT, developmental pathways, or tumor micro-environment could potentially be used to target pancreatic CSC. This may lead to a reduction of tumor growth, metastatic events, and chemoresistance in pancreatic cancer.

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“…The expression of VEGF in PC tissue is associated with the microvessel density (MVD) [71]. Furthermore, clinical and laboratory studies suggest that expression of pro-angiogenic markers such as epidermal growth factor (EGF), VEGF, and thymidine phosphorylase on malignant cells including PC are all positively associated with an increase in angiogenesis and a poor prognosis [48,76]. …”

Section: Factors That Can Enhance Thrombosis In Pcmentioning

confidence: 99%

The Hemostasis Apparatus in Pancreatic Cancer and Its Importance beyond Thrombosis

Echrish

Madden

Greenman

et al. 2011

Cancers

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Laboratory evidence of aberrant coagulation is found in the majority of patients with advanced pancreatic cancer and a clinical consequence of this is the high incidence and prevalence of vascular thromboembolic events. Other sequelae are hypothesized to be the facilitation and acceleration of mechanisms that define the malignant phenotype, such as invasion, trafficking and anchoring, establishing the metastatic niche and inducing angiogenesis. We review the in vitro and preclinical evidence that supports the role of the coagulation apparatus in the metastatic process of pancreatic cancer, with a particular emphasis on interaction of this pathway with clinically-targeted growth factor receptor pathways. Links between hemostasis, angiogenesis and epidermal growth factor pathways and their significance as therapeutic targets are considered.

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Angiogenesis in pancreatic carcinoma

Cited by 84 publications

References 41 publications

A high peripheral microvessel density count correlates with a poor prognosis in pancreatic cancer

A high peripheral microvessel density count correlates with a poor prognosis in pancreatic cancer

Cancer Stem Cells, EMT, and Developmental Pathway Activation in Pancreatic Tumors

The Hemostasis Apparatus in Pancreatic Cancer and Its Importance beyond Thrombosis

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