Angiogenesis in Wound Healing

Mendonça, Ricardo José de

doi:10.5772/26279

Cited by 6 publications

(2 citation statements)

References 55 publications

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“…The sequences described fits in the four phases of wound healing i.e., hemostasis (immediate), inflammation (1st–4th day), proliferation or re-epithelialization/contraction (4th–21st day) and remodeling (21st day to 2 years) (Li et al, 2007 ; Orsted et al, 2011 ; Daunton et al, 2012 ; Soni and Singhai, 2012 ). Some authors however have compressed the phases of wound healing in three phases inflammatory (including clotting), proliferative and remodeling (Wild et al, 2010 ; Mendonca, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Wound Healing Properties of Selected Plants Used in Ethnoveterinary Medicine

et al. 2017

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Plants have arrays of phytoconstituents that have wide ranging biological effects like antioxidant, anti-inflammatory and antimicrobial properties key in wound management. In vivo wound healing properties of ointments made of crude methanolic extracts (10% extract w/w in white soft paraffin) of three plant species, Cissus quadrangularis L. (whole aerial plant parts), Adenium multiflorum Klotzsch (whole aerial plant parts) and Erythrina abyssinica Lam. Ex DC. (leaves and bark) used in ethnoveterinary medicine were evaluated on BALB/c female mice based on wound area changes, regular observations, healing skin's percentage crude protein content and histological examinations. White soft paraffin and 3% oxytetracycline ointment were used as negative and positive controls, respectively. Wound area changes over a 15 day period for mice treated with C. quadrangularis and A. multiflorum extract ointments were comparable to those of the positive control (oxytetracycline ointment). Wounds managed with the same extract ointments exhibited high crude protein contents, similar to what was observed on animals treated with the positive control. Histological evaluations revealed that C. quadrangularis had superior wound healing properties with the wound area completely returning to normal skin structure by day 15 of the experiment. E. abyssinica leaf and bark extract ointments exhibited lower wound healing properties though the leaf extract exhibited some modest healing properties.

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Section: Discussionmentioning

confidence: 99%

Wound Healing Properties of Selected Plants Used in Ethnoveterinary Medicine

et al. 2017

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“…OFG treatment can accelerate VEGF expression in a dose-dependent manner in healing tissue, but weak expression in the low-dose group was observed in serum on day 7. VEGF could promote angiogenesis by promoting the formation of endothelial cells and inducing newly formed blood vessels in wound healing [ 19 ]. However, it is different from our study.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effect and Mechanism of Oxytropis falcata Gel on Deep Second‐Degree Burn in Rats

Lin

Kai-jie

Shi

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Oxytropis falcata has long been used to treat inflammation, sores, and bleeding in Tibet. However, the burn remedy and underlying molecular mechanisms are not well understood. This study is aimed at assessing the effect of Oxytropis falcate gel (OFG) on deep second-degree burn rats and exploring its mechanism. Wistar rats with second-degree burn were treated with OFG and silver sulfadiazine. Immunohistochemical detections for EGF and VEGF were performed, and ELISA detections for EGF, VEGF, p38, and IL-1β in serum were determined. Rats treated with OFG (25, 50 g/kg) consisted of the major rhamnocitrin-3-O-β-neohesperidoside significantly accelerated incrustation (P < 0.001) and decrustation (P < 0.001). According to HE staining, edema and infiltration of inflammatory cells decrease apparently with good hyperplasia and incrustation in administration groups (7 d). The expressions of EGF and CD34 in OFG (25, 50 g/kg) treatment increased obviously from immunohistochemical assessment (7 d). Serum EGF expression reached 321.27 ± 7.20 ng/mL by OFG treatment, while p38 (P < 0.05) and IL-1β (P < 0.05) levels were significantly lower than the model and vehicle groups from day 1 to day 7. OFG possesses potential wound healing activities. The mechanism may be related to the increasing of biosynthesis and the releasing of EGF and CD34 and the decreasing p38 and IL-1β levels.

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Dynamic optical coherence tomography for imaging acute wound healing

Schuh,

Berger,

Schiele

et al. 2024

International Wound Journal

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The aim of this study was to investigate acute wound healing with dynamic optical coherence tomography (D‐OCT). From 22 patients with 23 split skin graft donor sites, vessels at four wound edges, the wound bed, and adjacent and unaffected skin of the contralateral leg were measured by D‐OCT at six time points from surgery to 4 weeks of healing. Changes in vessel orientation, density, diameter, morphology and pattern in horizontal, vertical and 3D images were analysed for wound healing and re‐epithelialization. At 300 μm depth, there were significant differences of blobs and serpiginous vessels between normal and wounded skin. The wound had significantly more vertically oriented vessels, a higher degree of branching, vessel density and diameter compared with healthy skin. 3D images showed increased angiogenesis from healthy skin towards the wound centre, significantly higher vessel density at the wound than at normal skin and the highest at the interface. During wound healing blobs, coils and serpiginous vessels occurred significantly more frequently in lesional than healthy skin. Vessel density was greatest at the beginning, decreased and then increased by 4 weeks post‐surgery. D‐OCT helps to evaluate acute wound healing by visualizing and quantifying blood vessel growth in addition to re‐epithelialization.

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Angiogenesis in Wound Healing

Cited by 6 publications

References 55 publications

Wound Healing Properties of Selected Plants Used in Ethnoveterinary Medicine

Wound Healing Properties of Selected Plants Used in Ethnoveterinary Medicine

Therapeutic Effect and Mechanism of Oxytropis falcata Gel on Deep Second‐Degree Burn in Rats

Dynamic optical coherence tomography for imaging acute wound healing

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