Angiogenic activity of Synadenium umbellatum Pax latex

Melo-Reis, PR; Ls, Andrade; Silva, CB; Araújo, Lmm; Pereira, Max Domingues; Mrué, Fátima; Chen-Chen, Lee

doi:10.1590/s1519-69842010000100026

Cited by 26 publications

(16 citation statements)

References 21 publications

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“…Observations similar to those of our study have been reported in previous studies using other species belonging to the Euphorbiaceae family (Melo-Reis et al, 2010;Mendonça, 2004;Mrué, 2000). Latex from Hevea brasiliensis (rubber tree) increased angiogenic activity and promoted esophagus regeneration in dogs (Mrué, 1997).…”

Section: Discussionsupporting

confidence: 93%

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Angiogenic activity of latex from Euphorbia tirucalliLinnaeus 1753 (Plantae, Euphorbiaceae)

et al. 2015

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To assess the pro-angiogenic activity of Euphorbia tirucalli, commonly known as "avelós" plant, we performed a series of tests by applying an aqueous E. tirucalli latex solution (10 mg/mL) to the chorioallantoic membranes (CAMs) of 80 fertilized chicken eggs incubated in a temperature-and humidity-controlled automatic incubator. The results indicated that the aqueous latex solution increased vascular network formation compared to that with the negative control (p < 0.05) and the inhibitor control (p < 0.05). This suggests that under the experimental conditions tested, the aqueous latex solution induced an inflammatory response leading to neoangiogenesis.Keywords: angiogenesis, chorioallantoic membrane, Euphorbia tirucalli. Atividade angiogênica do látex da Euphorbia tirucalliLinnaeus 1753 (Plantae, Euphorbiaceae) ResumoCom o objetivo de analisar a atividade angiogênica apresentada pela Euphorbia tirucalli, popularmente conhecida comumente como "avelós", foram realizados ensaios utilizando solução aquosa de látex na concentração de 10 mg/ml, aplicada em membrana corioalantóide (MCA) de 80 ovos férteis de galinha, incubado em estufa automática com temperatura e umidade controladas. Os resultados apontaram que a ação da solução aquosa provocou aumento da percentagem da rede vascular formada em relação aos controles negativo (p<0,05) e inibidor (p<0,05), indicando que nas condições deste experimento, foi responsável pela ativação da resposta inflamatória e crescimento de novos vasos sanguíneos.Palavras-chave: angiogênese, membrana corioalantóide, Euphorbia tirucalli.

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Section: Discussionsupporting

confidence: 93%

“…Medicinal plants and substances extracted from them have been used for thousands of years, fostering the prevention and treatment of disorders and dysfunctions in humans (Farnsworth et al, 1985;Ortêncio, 1997 (Juárez et al, 2000;Choi et al, 2002;Wang et al, 2004;Melo-Reis et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Angiogenic activity of latex from Euphorbia tirucalliLinnaeus 1753 (Plantae, Euphorbiaceae)

et al. 2015

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“…Extracts from the Euphorbiaceae plants have been used in wound healing, treatment of ear infections, malaria, diarrhea, heart diseases, diabetes, hemorrhages, hepatitis, jaundice and scabies (Mwine and Van Damme, 2011). In the eastern and southern Africa regions, the plants are used to treat stomach-ache, urinal-genital problems, excessive menstruation, tuberculosis and cardiac palpitations (Melo-Reis et al, 2010). The plant Synadenium glaucescens, which belongs to this family, is widely used in Tanzania to treat various diseases including skin conditions, sores and wounds (Chhabra et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Effect of crude root extract from Synadenium glaucescens on selected bacterial infections in albino mice (Mus musculus)

Max¹,

Mwageni²,

Bakari³

2014

J. Med. Plants Res.

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Studies were carried out to investigate the effect of root extract from a tropical plant Synadenium glaucescens against two pathogenic species of bacteria in mice. A total of 120 mice were used in two experiments involving two bacterial species, Staphylococcus aureus and Pseudomonas aeruginosa. In each experiment, 60 mice were randomly divided into 6 groups with or without bacterial infection and with or without root extract. Clinical signs and survival of the mice were monitored; skin, kidneys and livers were examined for gross lesions, histopathological changes and bacterial counts. Results indicated that mice infected with the two bacteria and treated with the root extract from S. glaucescens had significantly less (P < 0.05) severe skin lesions compared to mice from the untreated groups. Histopathological examination of liver and kidney tissues showed hydropic degeneration and inflammatory reaction in uninfected groups receiving the extracts. Protein in tubular lumens, desquamated tubular epithelium and necrosis around central veins were observed in livers of mice infected with S. aureus and treated with the extract at 50 mg/kg body weight. It is concluded that root extract from S. glaucescens had significant antibacterial activity against the tested bacteria. Histopathological changes in the kidneys and livers of mice which received the extract alone suggested that high doses of the tested extract could be harmful to the mice. Further studies are needed to find out optimum dosage and whether the extract is harmful to other organs.

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“…As redes vasculares formadas nas MCAs foram quantificadas pelo processamento da imagem utilizando o programa de domínio público Gimp for Windows (versão 2.0.5) e Image J (versão 1.28) para visualização dos vasos sanguíneos (Wilting et al, 1991, Melo-Reis et al, 2010.…”

Section: Procedimento Experimental Da Angiogêneseunclassified

“…Foram avaliadas as presenças de angiogênese e de elementos inflamatórios Melo-Reis et al, 2010;Araújo et al, 2015;Bessa et al, 2015).…”

Section: Procedimento Experimental Da Angiogêneseunclassified

Avaliação da atividade angiogênica da solução aquosa do barbatimão (Stryphnodendron adstringens)

Chaves

Lemes

Araújo

et al. 2016

Rev. bras. plantas med.

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RESUMO:O Barbatimão (Stryphnodendron adstringens) planta medicinal encontrada no bioma Cerrado apresenta propriedades físico-químicas que lhe garante importantes atividades farmacológicas tais como: anti-inflamatória, analgésica e uma atividade protetora da mucosa gástrica. A casca do tronco é a principal matéria-prima usada para o desenvolvimento de produtos medicinais. Neste estudo, o objetivo foi investigar a influência da solução aquosa da casca do barbatimão no processo de formação de vasos sanguíneos na membrana corioalontoide de ovo embrionado de galinha. Foram utilizadas 30g da casca triturada em um litro de água. Este processo permitiu a obtenção da Solução Aquosa de Barbatimão -SAB em uma concentração de 30mg/mL. A atividade angiogênica da solução aquosa do barbatimão foi avaliada mediante realização de testes laboratoriais "in vivo", utilizando como modelo experimental a membrana do ovo embrionado de galinha (MCA). Utilizou-se como controle indutor o Regederm®, o qual apresenta atividade angiogênica conhecida. Os resultados demonstraram que a SAB apresentou um percentual de vascularização na MCA de (50.4%) não tendo diferença (p>0,05) aos valores detectados no controle indutor (52,9%). Com os resultados obtidos, percebe-se que o barbatimão apresenta atividade angiogênica no modelo experimental utilizado.Palavras chave: Angiogênese, barbatimão, membrana, ovo.ABSTRACT: Angiogenic activity of the aqueous solution of Barbatimão (Stryphnodendron adstringens).The Barbatimão (Stryphnodendron adstringens) medicinal plant found in the Cerrado biome has physicochemical properties which guarantee important pharmacological activities such as anti-inflammatic, analgesic and protective activities of gastric mucosa. The bark of the trunk is the main raw material used for the development of medicinal products. In this study, the objective was to investigate the influence of the aqueous solution of barbatimão bark in the formation of blood vessels in the membrane of embryonated chicken egg corioalontoid. 30g of shredded bark was used in one liter of water. This process enabled the obtention of aqueous Barbatimão -BSA at a concentration of 30mg / ml. The angiogenic activity of the aqueous solution of barbatimão was assessed by laboratory testing "in vivo", using the chorioallantoic membrane of embryonated chicken egg (MCA) as an experimental model. TheRegederm® controlinductor was used, which exhibits known angiogenic activity. The results showed that the percentage of BSA showed a vascularization of the MCA (50.4%) there was no difference (p> 0.05) in the values detected in the control inductor (52.9%). With the obtained results, it is clear that barbatimão shows angiogenic activity under the experimental model used.

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Angiogenic activity of Synadenium umbellatum Pax latex

Cited by 26 publications

References 21 publications

Angiogenic activity of latex from Euphorbia tirucalliLinnaeus 1753 (Plantae, Euphorbiaceae)

Angiogenic activity of latex from Euphorbia tirucalliLinnaeus 1753 (Plantae, Euphorbiaceae)

Effect of crude root extract from Synadenium glaucescens on selected bacterial infections in albino mice (Mus musculus)

Avaliação da atividade angiogênica da solução aquosa do barbatimão (Stryphnodendron adstringens)

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