Angiogenic and antiangiogenic factors in preeclampsia

Helmo, Fernanda Rodrígues; Lopes, Angela Maria Moed; Carneiro, Anna Cecília Dias Maciel; Campos, Carolina Guissoni; Silva, Polyana Barbosa; Monteiro, Maria Luíza Gonçalves dos Reis; Rocha, Laura Penna; Reis, Marlene Antônia dos; Etchebehere, Renata Margarida; Machado, Juliana Reis; Corrêa, Rosana Rosa Miranda

doi:10.1016/j.prp.2017.10.021

Cited by 59 publications

(53 citation statements)

References 105 publications

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“…The positive association of the angiogenic factor, PlGF with measures of child SST adiposity, has to our knowledge not previously been reported. These associations may reflect that PlGF is a marker of healthy placental function, associated with placental angiogenesis and reduced vascular resistance . Theoretically, higher PIGF and reduced placental vascular resistance could enhance nutrient transport and predispose the child to increased adiposity and later obesity.…”

Section: Discussionmentioning

confidence: 99%

“…These associations may reflect that PlGF is a marker of healthy placental function, associated with placental angiogenesis and reduced vascular resistance. 39 Theoretically, higher PIGF and reduced placental vascular resistance could enhance nutrient transport and predispose the child to increased adiposity and later obesity. Of relevance, a recent study addressing the relationship between later pregnancy PlGF and infant birth weight found a significant association between PlGF and macrosomia, although this was an investigation of mothers with preexisting diabetes.…”

Section: Discussionmentioning

confidence: 99%

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Relationships of maternal body mass index and plasma biomarkers with childhood body mass index and adiposity at 6 years: The Children of SCOPE study

et al. 2019

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Summary Background Maternal obesity has been implicated in the origins of childhood obesity through a suboptimal environment in‐utero. Objective We examined relationships of maternal early pregnancy body mass index (BMI), overweight/obesity, and plasma biomarkers of obesity, inflammation, insulin resistance, and placental function with measures of childhood BMI and adiposity. Methods BMI z‐score, sum of skinfold thicknesses (SST), body fat percentage (BFP, by bioelectrical impedance), and waist, arm, and hip circumferences were measured in 1173 6‐year‐old children of nulliparous pregnant women in the Screening for Pregnancy Endpoints (SCOPE) study, New Zealand. Relationships of maternal early pregnancy (15 weeks' gestation) BMI and biomarkers with these childhood anthropometric measures were assessed by linear regression, with appropriate adjustment. Results 28.1% of mothers were classified as overweight and 10.1% with obesity; compared with normal weight mothers, the BFP of their children were 5.3% higher (0.16 SD [95% CI, 0.04‐0.29] p = .01) and 7.8% higher (0.27 [0.08‐0.47] p = .006) with comparable values for BMI z‐score and arm, waist, and hip circumferences. Early pregnancy maternal BMI and plasma placental growth factor (PlGF) were associated with higher child's SST, BMI z‐score, hip circumference, and BFP. None of the metabolic or inflammatory maternal biomarkers were associated with childhood obesity. Conclusion In this contemporary large prospective cohort study with extensive maternal/childhood phenotyping and a high prevalence of maternal overweight/obesity, we found independent relationships of maternal early pregnancy BMI with childhood BMI and adiposity; similar associations were observed with PlGF, which may imply a role for placenta function in the developmental programming of childhood obesity risk.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationships of maternal body mass index and plasma biomarkers with childhood body mass index and adiposity at 6 years: The Children of SCOPE study

et al. 2019

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“…sEng is less secreted in normal tissues and increased in hypoxia. Many studies have shown that sEng is significantly elevated in patients with preeclampsia . Levine et al showed that the level of sEng in serum began to rise 8‐10 weeks before the onset of preeclampsia symptoms.…”

Section: Introductionmentioning

confidence: 99%

The diagnosis values of serum STAT4 and sEng in preeclampsia

Zhang¹,

Li²,

Zhou³

et al. 2019

Clinical Laboratory Analysis

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Objective To detect the levels of signal transducer and activator of transcription 4 (STAT4) and soluble endoglin (sEng) in preeclampsia patients and analyze the diagnostic values of STAT4 and sEng in preeclampsia. Methods Fifty‐four pregnant women with preeclampsia from October 2017 to June 2018 were included in this study. Twenty‐eight matched healthy pregnant women were set as the control group. The general clinical characteristics were measured. Serum STAT4 and sEng were detected by ELISA. Correlation between STAT4 and sEng, and their diagnostic value in preeclampsia were analyzed. Results Compared with control, the prothrombin time in preeclampsia was significantly lower, while the mean arterial pressure, 24‐hour urine protein, serum creatinine, fibrinogen, and ALT were significantly higher. The circulating levels of STAT4 and sEng were significantly increased in the preeclampsia. The serum levels of STAT4 and sEng in preeclampsia were positively correlated. For the diagnosis of preeclampsia by the serum STAT4, AUC is 0.902, and the sensitivity and specificity are 0.893 and 0.929. By the serum sEng, AUC is 0.873, and the sensitivity and specificity are 0.816 and 0.905. Conclusion The serum levels of STAT4 and sEng were significantly increased in preeclampsia with disease severity status, which have promise as diagnostic markers in preeclampsia.

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“…Despite intensive research, etiopathogenesis of preeclampsia has not been fully elucidated. Among predisposing factors that exist before pregnancy the following can be enumerated: chronic arterial hypertension, obesity, diabetes, young age, hyperhomocysteinemia, history of preeclampsia, and family history of preec-lampsia [1,4,5]. Predisposing factors that are connected with the pregnancy include: gestational diabetes, urinary tract infection, fetal anasarca, multifetal gestation.…”

mentioning

confidence: 99%

“…During physiological gestation, cells of the developing cytotrophoblast penetrate the wall of the uterus and cause the remodeling of spiral arteries, which enables normal placental development. In the instances of disturbed trophoblast invasion, spiral arteries remain narrow, highly resistant, which greatly limits the blood flow through developing placenta [1,2,4,6]. This initiates a cascade of events leading to the disease that includes significant alterations of the renin-angiotensin-aldosterone system (RAAS) [1,7,8].…”

mentioning

confidence: 99%

Renin-Angiotensin-Aldosterone System in the Pathogenesis of Pregnancy-Induced Hypertension

Świątkowska−Stodulska

Kmieć

Stefańska

et al. 2018

Exp Clin Endocrinol Diabetes

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Hypertension occurs in 7-10% of pregnant women. Despite the continuous development of medicine, it is still an important risk factor for perinatal mortality of both mothers and fetuses. Pregnant women with hypertension are at greater risk of complications such as: placental abruption, cerebral and cardiac incidents, multiorgan failure, and disseminated intravascular coagulation. The aim of this review was to discuss multilevel disorders of the renin-angiotensin-aldosterone system in the etiopathogenesis of pregnancy-induced hypertension.

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Angiogenic and antiangiogenic factors in preeclampsia

Cited by 59 publications

References 105 publications

Relationships of maternal body mass index and plasma biomarkers with childhood body mass index and adiposity at 6 years: The Children of SCOPE study

Relationships of maternal body mass index and plasma biomarkers with childhood body mass index and adiposity at 6 years: The Children of SCOPE study

The diagnosis values of serum STAT4 and sEng in preeclampsia

Renin-Angiotensin-Aldosterone System in the Pathogenesis of Pregnancy-Induced Hypertension

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