Angiogenic growth factors in human dentine matrix

Roberts-Clark, D. J.; Smith, Anthony J.

doi:10.1016/s0003-9969(00)00075-3

Cited by 304 publications

(227 citation statements)

References 15 publications

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“…VEGFR-2 is expressed in endothelial cells of the tooth pulp of both primary and permanent human teeth and may function to respond to morphogenetic and survival signals mediated by VEGF (Grando Mattuella et al 2007). As stated previously, VEGF, as well as FGF, PDGF, and EGF, are found in dentin matrix (Roberts-Clark and Smith 2000).…”

Section: Discussionsupporting

confidence: 77%

Incisor Degeneration in Rats Induced by Vascular Endothelial Growth Factor/Fibroblast Growth Factor Receptor Tyrosine Kinase Inhibition

et al. 2010

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BMS-645737, an inhibitor of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast growth factor (FGF) receptor-1, has antiangiogenic activity and was evaluated in nonclinical studies as a treatment for cancer. This article characterizes the BMS-645737-induced clinical, gross, and histologic lesions of incisor teeth in Sprague-Dawley (SD) rats. Rats received 0 800 mg/kg BMS-645737 in a single-dose study or consecutive daily doses of 0 20 mg/kg/day in a 1-month study. The reversibility of these effects was assessed in the 1-month study. White discoloration and fracture of incisors were observed clinically and grossly in the 1-month study. In both studies, dose-dependent histopathologic lesions of incisors were degeneration and/or necrosis of odontoblasts and ameloblasts; decreased mineralization of dentin; inflammation and necrosis of the dental pulp; and edema, congestion, and hemorrhage in the pulp and periodontal tissue adjacent to the enamel organ. Partial recovery was observed at lower doses after a two-week dose-free period in the one-month study. Drug-induced incisor lesions were considered to be related to the pharmacologic inhibitory effects on VEGF and FGF signaling, that is, inhibition of growth and maintenance of small-diameter vessels that support the formation of dentin and enamel in growing teeth and/or to perturbances of function of odontoblasts and ameloblasts or their precursors.

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Section: Discussionsupporting

confidence: 77%

Incisor Degeneration in Rats Induced by Vascular Endothelial Growth Factor/Fibroblast Growth Factor Receptor Tyrosine Kinase Inhibition

et al. 2010

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“…Growth factors, especially those of the transforming growth factor-beta (TGF ␤ ) family, are important in cellular signaling for odontoblast differentiation and stimulation of dentin matrix secretion. These growth factors are secreted by odontoblasts and deposited within the dentin matrix (Roberts-Clark and Smith, 2000), where they remain protected in an active form through interaction with other components of the dentin matrix (Smith et al, 1998). Carious demineralization of the dental tissues can lead to their release, as can application of cavity-etching agents and restorative materials .…”

Section: (B) Growth Factor Therapy To Stimulate Tissue Regeneration Bmentioning

confidence: 99%

Analysis of Pulpal Reactions to Restorative Procedures, Materials, Pulp Capping, and Future Therapies

Murray

Windsor

Smyth

et al. 2002

Critical Reviews in Oral Biology & Medicine

134

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Every year, despite the effectiveness of preventive dentistry and dental health care, 290 million fillings are placed each year in the United States; two-thirds of these involve the replacement of failed restorations. Improvements in the success of restorative treatments may be possible if caries management strategies, selection of restorative materials, and their proper use to avoid post-operative complications were investigated from a biological perspective. Consequently, this review will examine pulp injury and healing reactions to different restorative variables. The application of tissue engineering approaches to restorative dentistry will require the transplantation, replacement, or regeneration of cells, and/or stimulation of mineralized tissue formation. This might solve major dental problems, by remineralizing caries lesions, vaccinating against caries and oral diseases, and restoring injured or replacing lost teeth. However, until these therapies can be introduced clinically, the avoidance of post-operative complications with conventional therapies requires attention to numerous aspects of treatment highlighted in this review.

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“…Among these growth factors, angiogenic growth factors (VEGF) released from the matrix as a result of matrix breakdown during tissue injury or during pulp regeneration procedures by EDTA, could make an important contribution to the overall reparative/regenerative response of the dentine-pulp complex (64).…”

Section: Vascular Endothelial Growth Factor (Vegf)mentioning

confidence: 99%