Angiogenic growth factors released in human dental pulp following orthodontic force

Neuropeptides Regulate Expression of Angiogenic Growth Factors in Human Dental Pulp Fibroblasts

“…Furthermore, the levels of all 4 newly identified angiogenic factors in the dental pulp were higher than bFGF levels, suggesting potential physiologic roles in the dental pulp. The expression of VEGF, bFGF, PIGF, EGF, and HGF by pulp fibroblasts in vitro was confirmed, supporting previous work (4,17,18).…”

Vascular Endothelial Growth Factor Receptor–2 Expression in the Pulp of Human Primary and Young Permanent Teeth

“…This action is mediated by VEGFR-2 and partially by the signaling of the activator protein-1 (AP-1) transcription factor by the c-fos protein, although both receptors (VEGFR-1 and VEGFR-2) are present in pulp cells. Several studies have evaluated the role of VEGF in the dental pulp tissue (21)(22)(23)(24)(25)(26)(27)(28).…”

A Study of Physiologic Angiogenesis in the Human Using the Dental Pulp as an In Vivo Model

“…The microvascular bed arrangement of the dental pulp plays a major role in hard-and soft-tissue physiology, and thus its anatomy and histology have received considerable attention (Han and Avery 1963;Harris and Griffin 1971;Oguntebi 1986;Rapp 1992). Evidence has been provided demonstrating that angiogenic factors are released during routine dental procedures such as the orthodontic movement of teeth (Derringer et al 1996;Derringer and Linden 2003) and following tooth cavity preparation (Roberts-Clark and Smith, 2000). However, none of these 360 F. ARFUSO studies actually investigated the morphology of the developing vasculature.…”