Neuropeptides Regulate Expression of Angiogenic Growth Factors in Human Dental Pulp Fibroblasts

Immunohistochemical Evaluation of Angiogenesis and Tryptase-positive Mast Cell Infiltration in Periapical Lesions

“…MCs have been shown to express receptors for neuropeptides, which can activate MCs inducing cytokine production and mediator release (28), including a rich source of several potent angiogenic factors (9, 20, 21). Furthermore, neuropeptides have been shown to influence the release of angiogenic factors by pulp fibroblasts (29). Taken together, these findings suggest that neuropeptides can modulate angiogenesis in periapical lesions.…”

The Effect of Orthodontic Forces on Calcitonin Gene-related Peptide Expression in Human Dental Pulp

“…The minor alteration of pulpal blood flow and collateral circulation caused by vascular congestion initiates a compensatory mechanism that releases angiogenic growth factors to the extracellular space. These changes intend to avoid irreversible damage caused by a vascular breakdown (33,34).…”

Inflammation–regeneration interplay in the dentine–pulp complex

“…Indeed SP, CGRP, VIP and NPY may represent novel regulators of pulpal angiogenic events whilst CGRP and CT stimulated osteodentin deposition in ferret canines. 77,78 Clearly, further work is required in the study of this interesting class of molecules.…”