Angiogenic lncRNAs: A potential therapeutic target for ischaemic heart disease

Coronary vessel formation in development and disease: mechanisms and insights for therapy

“…We will specifically focus on the endogenous processes understood to occur in the heart in response to injury, rather than on the plethora of exogenous factors tested for their ability to induce coronary vessel growth. While non-coding RNAs [11][12][13] , various progenitor cell types 14,15 and extracellular vesicles 16 , either unmodified or tailored to deliver angiogenic factors, have shown promise in preclinical studies, they are either untested or have shown limited success in the clinic; moreover, the precise mechanisms underlying any enhanced neovascularisation have not been systematically investigated and are largely undefined. In contrast, emerging insights, for example from genetic lineage tracing and single cell transcriptomic studies are beginning to help us to understand the heart's intrinsic attempts to repair the coronary network and this may reveal novel targets for therapeutically enhancing such sub-optimal responses.…”

Upregulation of long noncoding RNA RP4 exacerbates hypoxia injury in cardiomyocytes through regulating miR-939/Bnip3/Wnt/β-catenin pathway

“…LncRNAs are also involved in the process of ischemic heart diseases [9][10][11]. Moreover, angiogenic lncRNAs have been considered as possible therapeutic targets for ischemic heart diseases [12]. Therefore, expounding of crucial lncRNAs involved in ischemic heart diseases will promote the process of effective therapies for halting these diseases.…”

Silencing long non-coding RNA MIAT ameliorates myocardial dysfunction induced by myocardial infarction via MIAT/miR-10a-5p/EGR2 axis

“…The poor outcome of patients with MI is attributable to the significant loss of cardiomyocytes and its impairment in the regeneration ability after MI [ 24 ]. Accumulating evidences highlights the vitality of lncRNAs in several cardiac diseases and with therapeutic capacity to treat cardiac injury [ 25 , 26 ]. However, detailed studies regarding lncRNAs and its regulatory mechanism in MI are still insufficient.…”