Angiogenin and vascular endothelial growth factor in pregnancies complicated by preeclampsia

Shaarawy, Mohamed; Al-Sokkary, F.; Sheba, Maha F.; Wahba, Odette; Kandil, H.O.; Abdel-Mohsen, I.

doi:10.1016/j.ijgo.2004.10.005

Cited by 31 publications

(13 citation statements)

References 29 publications

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“…It has been suggested that the vascular and nervous systems are functionally and structurally different but they share some multiple similarities in their development, construction, and function (Pucci et al, 2008). Recent studies suggest that dysregulation of angiogenic factors and their soluble fms‐like tyrosine kinase‐1 receptors (sFlt‐1) play an important role in the pathogenesis of pre‐eclampsia although the results are inconsistent (Laskowska et al, 2008; Shaarawy et al, 2005; De Vivo et al, 2008). It is suggested that sFlt‐1 and PlGF could together serve as predictors of pre‐eclampsia (Levine et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Nerve growth factor, birth outcome and pre‐eclampsia

Kilari¹,

Mehendale²,

Pisal³

et al. 2010

Intl J of Devlp Neuroscience

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The present study compares nerve growth factor (NGF) levels between preeclamptic (PE) (n=86) and normotensive (NT) women (n=105) and their associations with blood pressure and infant size. Maternal plasma NGF levels were reduced (p<0.05) in the PE group as compared to the NT group. Furthermore, NGF levels were reduced in PE mothers delivering low birth weight babies (LBW) as compared to NT mothers delivering LBW babies. Maternal NGF levels were negatively (p=0.029) associated with blood pressure in preeclamptic mothers. Cord NGF levels were negatively associated (p=0.026) with birth weight in the normotensive group. NGF levels are differently regulated in preeclamptic and normotensive mothers delivering LBW babies. Future studies need to investigate mechanisms underlying this pathophysiology and follow-up of these babies to better understand the role of NGF in brain development in later life.

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Section: Discussionmentioning

confidence: 99%

Nerve growth factor, birth outcome and pre‐eclampsia

Kilari¹,

Mehendale²,

Pisal³

et al. 2010

Intl J of Devlp Neuroscience

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“…4 Recent studies suggest that dysregulation of angiogenic factors and their soluble fmslike tyrosine kinase-1 receptors (sFlt-1) has an important role in the pathogenesis of preeclampsia, but the results are inconsistent. Although some studies report lower plasma vascular endothelial growth factor (VEGF) levels 5 in preeclamptic women compared with normotensive women, [6][7][8][9] other studies report higher levels in preeclamptic women, 10,11 and some found no difference between the two groups. 5 Placental growth factor (PlGF) is a placental protein that potentiates the effect of VEGF.…”

Section: Introductionmentioning

confidence: 99%

Circulating angiogenic factors and their association with birth outcomes in preeclampsia

et al. 2010

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This study was designed to test the hypothesis that altered angiogenic factors together with increased oxidative stress and reduced docosahexaenoic acid (DHA) levels may be associated with altered birth outcome parameters. To test this hypothesis, levels of plasma vascular endothelial growth factor (VEGF), placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), the oxidative stress marker malondialdehyde (MDA) and fatty acids were estimated in women with preeclampsia and their cord samples and compared with those in normotensive women. The association of these parameters with birth outcome was also examined. Our results show that in preeclamptic women, maternal plasma VEGF and PlGF levels were lower, whereas sFlt-1 levels were higher (Po0.05 for all) than in normotensive women. In contrast, cord plasma VEGF levels were higher (Po0.05) in preeclamptic women, whereas there was no difference in sFlt-1 levels. Plasma DHA levels in both the mother and cord were lower (Po0.05) in the preeclamptic group compared with normotensive women. Maternal plasma sFlt-1 levels were positively (n¼23, r¼0.415, P¼0.039) associated with MDA concentrations in preeclamptic women. Maternal plasma sFlt-1 levels showed a strong negative association with baby weight (n¼37, r¼À0.547, P¼0.001), head circumference (n¼37, r¼À0.472, P¼0.005) and baby chest circumference (n¼37, r¼À0.375, P¼0.032) in the preeclamptic group. Cord plasma sFlt-1 concentrations were negatively associated with cord plasma DHA concentrations (n¼28, r¼À0.552, P¼0.004). This study suggests that dysregulation of angiogenic factors may be associated with maternal oxidative stress. Increased oxidative stress may reduce cord DHA levels and increase sFlt-1 levels, leading to poor birth outcomes in preeclampsia.

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“…A finding that was reported by a number of groups (Reuvekamp et al, 1999;Koga et al, 2003;Polliotti et al, 2003;Tsatsaris et al, 2003). In the contrast, also several studies exist, which described rising VEGF protein levels in the patients serum (Kupferminc et al, 1997;Shaarawy et al, 2005) or umbilical cord blood (Galazios et al, 2004).…”

Section: Preeclampsiamentioning

confidence: 82%