2010
DOI: 10.1016/j.ijdevneu.2010.09.001
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Nerve growth factor, birth outcome and pre‐eclampsia

Abstract: The present study compares nerve growth factor (NGF) levels between preeclamptic (PE) (n=86) and normotensive (NT) women (n=105) and their associations with blood pressure and infant size. Maternal plasma NGF levels were reduced (p<0.05) in the PE group as compared to the NT group. Furthermore, NGF levels were reduced in PE mothers delivering low birth weight babies (LBW) as compared to NT mothers delivering LBW babies. Maternal NGF levels were negatively (p=0.029) associated with blood pressure in preeclampti… Show more

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Cited by 22 publications
(33 citation statements)
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“…This is in line with our earlier departmental study where we have reported cord NGF levels to be negatively associated with baby weight and length in the normotensive control group [36]. In contrast, others report a positive association with the infant centiles and birth weights [37].…”
Section: Discussionsupporting
confidence: 92%
“…This is in line with our earlier departmental study where we have reported cord NGF levels to be negatively associated with baby weight and length in the normotensive control group [36]. In contrast, others report a positive association with the infant centiles and birth weights [37].…”
Section: Discussionsupporting
confidence: 92%
“…In contrast, a study on serum NGF concentrations over the menstrual cycle and pregnancy (performed with an enzyme-linked immunosorbent assay for NGF) found no significant difference in NGF concentrations between pregnant women and age-matched nonpregnant women, although trends toward increased NGF were noted at week 37 of pregnancy and 1 week after parturition [10]. Serum NGF concentrations also were implicated as a potential biomarker in pregnancy for low birth weight associated with pre-eclampsia [8] as well as neurodevelopmental pathologies later in life [7], although serum NGF concentrations determined by enzyme-linked immunosorbent assay vary considerably [7][8][9][10].…”
Section: Discussionmentioning
confidence: 91%
“…Although NGF concentrations have been measured during pregnancy in humans [7][8][9][10], to date, little is known about NGF concentrations during pregnancy in animal species frequently utilized for embryo-fetal development studies, such as monkeys. The purpose of this study was to quantify NGF concentrations in pregnant female monkeys over the course of pregnancy and to compare them with nonpregnant female and male cynomolgus monkeys using a novel sensitive immunoaffinity liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay [11].…”
Section: Introductionmentioning
confidence: 99%
“…Recently, Kilari et al [20] compared 86 term PE patients with 105 normotensive controls with a blood sample obtained immediately prior to delivery. The PE group exhibited a significantly lower concentration of plasmatic NGF than the controls (257.6 vs. 316.3 pg/ml, respectively; p < 0.01).…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, a recent study by Kilari et al. [20] demonstrated that, at the moment of delivery, patients with PE have lower plasma concentrations of NGF than patients with normotensive pregnancies.…”
Section: Introductionmentioning
confidence: 99%