Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application

Sinning, Christoph; Lillpopp, Lars; Appelbaum, Sebastian; Ojeda, Francisco; Zeller, Tanja; Schnabel, Renate B.; Lubos, Edith; Jagodzinski, Annika; Keller, Till; Münzel, Thomas; Bickel, Christoph; Blankenberg, Stefan

doi:10.1007/s00392-013-0555-4

Cited by 145 publications

(115 citation statements)

References 23 publications

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“…Although SYNTAX score could be used for this purpose, it has been used frequently to risk-stratify patients with complex CAD undergoing percutaneous coronary intervention. Also, it was previously implied that The SYNTAX and Gensini score in combination with clinical variables could be used to predict the CV prognosis during a long-term follow-up of up to eight years in CAD patients and there is a significant positive correlation between them [29]. Moreover, physicians can include all coronary lesions, which amounts to even less than 50% in the Gensini scoring system, although it is an older scoring system than SYNTAX.…”

Section: Limitations Of the Studymentioning

confidence: 99%

The effect of epicardial adipose tissue thickness on left ventricular diastolic functions in patients with normal coronary arteries

Topuz

Doğan

2017

Kardiol Pol

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A b s t r a c t Background and aim:The aim of this study is to evaluate the effect of epicardial adipose tissue (EAT) thickness on left ventricular diastolic functions in patients with normal coronary arteries (NCA) proven by angiography. Methods:We selected study patients who were referred to coronary angiography due to typical chest pain or atypical chest pain with a positive pre-test result for coronary artery disease (CAD). After coronary angiography, 85 patients with significant coronary lesion (≥ 50% stenosis) served as the CAD group, 82 patients with non-significant coronary lesion (< 50% stenosis) and/or a coronary plaque served as the non-significant CAD group, and 83 patients with NCA served as the NCA group. All patients underwent transthoracic echocardiographic examination to measure EAT thickness and left ventricular diastolic properties.Results: Gensini score, total cholesterol, and C-reactive protein were significantly higher in the CAD group compared to the non-significant CAD group and the NCA group. The average of EAT thickness was 7.3 ± 2.4 mm in all groups. It was 5.8 ± 2.3 mm in the NCA group, 6.4 ± 2.4 mm in the non-significant CAD group, and 7.8 ± 2.2 mm in the CAD group (p < 0.001). In correlation analyses, average EAT thickness was significantly correlated with E/e' ratio in the NCA group. In multivariate analysis, average of EAT thickness was significantly associated with left ventricular diastolic dysfunction in subjects with NCA (OR 1.019, 95% CI 1.012-1.027, p < 0.001).Conclusions: Based on our findings, EAT thickness may have an effect on left ventricular diastolic functions. This independent relationship showed us the clinical importance of measuring of EAT thickness.

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Section: Limitations Of the Studymentioning

confidence: 99%

The effect of epicardial adipose tissue thickness on left ventricular diastolic functions in patients with normal coronary arteries

Topuz

Doğan

2017

Kardiol Pol

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“…Stenosis severity was evaluated based on Gensini scores (GS) 29) by two experienced cardiologists blinded to experimental data. Patients were grouped according to GS tertile (low, GS 18; intermediate, high, GS 41) [29][30][31][32][33] . Demographic data, classical cardiovascular risk factors, laboratory assay results, and previous medical treatment records were collected.…”

Section: Introductionmentioning

confidence: 99%

Reduced T-Cell Thymic Export Reflected by sj-TREC in Patients with Coronary Artery Disease

Huang

Ding

Lin

et al. 2016

J Atheroscler Thromb

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Aim:Immunologic dysfunction was recently found to be one of the most important mechanisms underlying the initiation and development of atherosclerosis. Thymus involution can contribute to immune disturbance and disequilibrium of T-cell subsets. This study aimed to explore whether recent thymic emigration (RTE) is impaired in patients with coronary artery disease (CAD). Methods: Content of signal-joint T cell receptor excision circles (sj-TREC) in T lymphocytes, a molecular marker of RTE, was assessed among CAD patients and age-matched controls. Monochrome multiplex quantitative PCR method was used to assess the samples' telomere length in order to exclude the potential influence of T cell proliferation on the dilution of sj-TREC. Patients were grouped according to Gensini score (GS) (low, GS 18; intermediate, GS 18 -41; high, GS 41). Ordinary logistic regression models were used to determine potential risk factors for CAD and GS tertiles. Results: Average copy numbers of sj-TREC per 10 6 T lymphocytes among patients with unstable angina, stable angina, and controls were 726 429, 1213 465, and 1795 838, respectively (P 0.001). However, there was no significant difference in telomere length among groups. Moreover, the content of sj-TREC in the high GS group was most significantly reduced than the low GS group (P 0.001). Multivariate logistic regression analysis revealed that lower sj-TREC was independently associated with the progression of CAD (OR 0.44, P 0.001) and higher GS (OR 0.4, P 0.001). Conclusion: Impaired RTE could be partly responsible for CAD development. Mechanisms may be involved in the disturbance of T lymphocyte compartment and interruption of maintained immune tolerance resulting from thymus involution. J Atheroscler Thromb, 2016; 23: 632-643.

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“…6 Sinning C et al also proposed that both Syntax scoring system and Gensini scoring system in combination with clinical variables could be used to predict the cardiovascular prognosis in CAD patients even during long-term follow-up. 7 Gensini coring systems therefore appear to be a valid estimate of CAD plaque burden. 6 Similar to our findings, Sinan DO et al also found association of serum uric acid level with the presence and severity of CAD.…”

Section: Discussionmentioning

confidence: 98%

A study of angiographic severity in patients with coronary artery disease and hyperuricemia

Pramanik¹,

Mondal

Dey³

et al. 2015

Asian J Med Sci

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Backgrounds: Hyperuricemia has not yet been established as cardiovascular risk factor. We aimed to study the angiographic severity in patients with coronary artery disease (CAD) and hyperuricemia.Materials and Methods: In this observational cross-sectional study we measured serum uric acid level in 82 patients of CAD who underwent coronary angiography in catheterisation laboratory of our Institution. Severity of CAD was determined on the basis of Gensini score, number of diseased vessels, critical lesions and total occlusions.Results: The prevalence of hyperuricemia in patients with CAD was 42.68% in our study. Hyperuricemia was associated with higher Gensini score (33.33±10.64 vs. 22.90±6.75, p value <0.001), number of critical lesions (1.03±0.84 vs. 0.63±0.72, p value 0.031), total occlusions (0.67±0.47 vs. 0.37±0.48, p value 0.007) and dyslipidemia (63.6% vs. 30.6%, p value 0.003) more frequently compared to normouricemic patients. And also the higher serum uric acid level was correlated with higher Gensini score (beta 0.418, t 4.430, p value <0.001, 95% CI 0.036 and 0.094) and frequent number of total occlusion (beta 0.338, t 3.589, p value 0.001, 95% CI 0.462 and 1.613).Conclusion: Hyperuricemia was associated with higher Gensini score, frequent total occlusions and critical lesions in patients with Coronary Artery Disease compared to patients with normal uric acid level and also it was significantly correlated with higher Gensini score and frequent total occlusions.Asian Journal of Medical Sciences Vol.7(2) 2015 1-4

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Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application

Abstract: The SYNTAX and Gensini score in combination with clinical variables could be used to predict the cardiovascular prognosis during a long-term follow-up of up to 8 years in CAD patients.

Cited by 145 publications

References 23 publications

The effect of epicardial adipose tissue thickness on left ventricular diastolic functions in patients with normal coronary arteries

The effect of epicardial adipose tissue thickness on left ventricular diastolic functions in patients with normal coronary arteries

Reduced T-Cell Thymic Export Reflected by sj-TREC in Patients with Coronary Artery Disease

A study of angiographic severity in patients with coronary artery disease and hyperuricemia

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