Angioinvasive fungal infections impacting the skin

Shields, Bridget E.; Rosenbach, Misha; Brown‐Joel, Zoe O.; Berger, Anthony P.; Ford, Bradley; Wanat, Karolyn A.

doi:10.1016/j.jaad.2018.04.059

Cited by 56 publications

(29 citation statements)

References 135 publications

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“…This process can produce a spectrum of gross pathology, ranging from nonspecific petechial hemorrhages to hemorrhagic geographic necrosis and well-circumscribed necrotic mass lesions, as illustrated by this case series. The variably targetoid "bull's-eye" appearance of lesions is secondary to zonal, vasocentric necrosis (1,13). A Figure 5: Case 3.…”

Section: Discussionmentioning

confidence: 99%

“…There are frequent descriptions and illustrations of the clinical appearance of mucormycosis in the literature. In contrast, the gross appearance of mucormycosis at autopsy is not well characterized, and there are relatively few published articles depicting the lesions postmortem (1,(5)(6)(7)(8). We present four autopsy cases of mucormycosis (three disseminated, one pulmonary) that demonstrated characteristic hemorrhagic infarcts with a targetoid appearance in organs infected by Mucorales.…”

Section: Introductionmentioning

confidence: 90%

“…Infection results from inhalation of spores or inoculation via disrupted skin or mucosa, and most commonly occurs in immunocompromised hosts, such as those with a history of hematologic or solid organ transplantation, hematologic malignancy, or neutropenia. Additional risk factors include poorly controlled diabetes mellitus, iron overload syndromes, and iron chelation therapy with deferoxamine, which is no longer commonly used (1)(2)(3). In the United States health care system the mean incidence is 0.3 cases per 100,000 patients per year (4).…”

Section: Introductionmentioning

confidence: 99%

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The Postmortem Features of Mucormycosis

Halvorson¹,

Isaacson²,

Ford³

et al. 2020

Academic Forensic Pathology

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Mucormycosis is a rare and severe invasive fungal infection caused by ubiquitous fungi of the order Mucorales. Infection often occurs in immunocompromised hosts and includes cutaneous, pulmonary, gastrointestinal, rhinocerebral, and disseminated forms of disease. Although the clinical characteristics of mucormycosis are well established, infection can be difficult to diagnose antemortem, resulting in frequent postmortem diagnoses. Despite this, the gross appearance of mucormycosis at autopsy has not been well described. In the present report we illustrate the gross and histologic findings in four autopsy cases of mucormycosis, including one case of pulmonary disease and three cases of disseminated mucormycosis with cerebral, pulmonary, hepatic, renal, and gastrointestinal involvement. In all cases autopsy examination demonstrated characteristic hemorrhagic infarcts with a targetoid appearance in the affected organs. These findings are secondary to fungal angioinvasion with subsequent thrombosis and tissue necrosis. Mucormycosis should be suspected at autopsy when these characteristic infarcts are identified within the proper clinical context, and a high suspicion for atypical infections should be maintained postmortem in immunosuppressed patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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The Postmortem Features of Mucormycosis

Halvorson¹,

Isaacson²,

Ford³

et al. 2020

Academic Forensic Pathology

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“…Additionally, the fungal organisms depicted on the punch biopsy and wet mount are not characteristic for candidiasis. 2 …”

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confidence: 99%

“… Environmental exposure – Incorrect. Although Mucor species are ubiquitous and commonly found in humid organic matter such as composting vegetation or rotting fruit, 1 , 2 most people are exposed to these same substances and do not go on to have invasive mucormycosis. Classical risk factors for mucormycosis include immunosuppression, hematologic malignancy, poorly controlled diabetes, diabetic ketoacidosis, iron overload or neutropenia.…”

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confidence: 99%

Dusky violaceous necrotic plaques of the chest

2020

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Advances in Antimicrobial Microneedle Patches for Combating Infections

et al. 2020

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Skin infections caused by bacteria, viruses and fungi are difficult to treat by conventional topical administration because of poor drug penetration across the stratum corneum. This results in low bioavailability of drugs to the infection site, as well as the lack of prolonged release. Emerging antimicrobial transdermal and ocular microneedle patches have become promising medical devices for the delivery of various antibacterial, antifungal, and antiviral therapeutics. In the present review, skin anatomy and its barriers along with skin infection are discussed. Potential strategies for designing antimicrobial microneedles and their targeted therapy are outlined. Finally, biosensing microneedle patches associated with personalized drug therapy and selective toxicity toward specific microbial species are discussed.

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Angioinvasive fungal infections impacting the skin

Cited by 56 publications

References 135 publications

The Postmortem Features of Mucormycosis

The Postmortem Features of Mucormycosis

Dusky violaceous necrotic plaques of the chest

Advances in Antimicrobial Microneedle Patches for Combating Infections

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