Angiomatosis: A Case With Metaplastic Ossification

Abstract

Angiomatosis is defined as a hemangioma that affects a large segment of the body in a contiguous fashion, either by vertical extension to involve multiple tissue planes (eg, skin, subcutis, muscle, bone) or by crossing muscle compartments to involve similar tissue types (eg, multiple muscles). Such lesions usually present in the first 2 decades of life and have a highly characteristic but not totally specific histological pattern. Histology usually shows a haphazard mixture of small and medium-sized vessels, fat, connective tissue, and lymphatics. Large amounts of mature fat frequently accompany the vascular elements, suggesting that the lesion may possibly be a more generalized mesenchymal proliferation rather than an exclusively vascular lesion. Here we present what we believe to be the first case of angiomatosis showing osseous metaplasia.

Angiomatosis: A rare vascular proliferation of head and neck region

“…Large amount of mature fat frequently accompanying the vascular elements seen in angiomatosis suggest that this lesion may possibly be a generalised mesenchymal proliferation rather than an exclusively vascular lesion. [ 8 ]…”

“…However, in angiolipoma proliferating vessels are usually concentrated at the periphery of intratumoral lobules of adipocytes and the lesion is quite well circumscribed. [ 8 ] Other differential diagnosis includes angiomyolipoma, infiltrating lipoma, angiomyxolipoma and liposarcoma. Angiomyolipoma can be differentiated from angiomatosis as it contains smooth muscle in addition to blood vessels and fat while angiomyxolipoma is distinguished by the presence of myxoid change in adipose tissue and absence of haphazard blood vessel proliferation.…”

Skeletal muscle metastases: primary tumours, prevalence, and radiological features

“…In addition, MO occurs predominantly in the muscles of the extremities, although other localisations, such as paravertebral musculature are also known [55]. Other causes of muscle calcifications, such as calcific tendinitis, angiomatosis, systemic sclerosis, and calcific myonecrosis must also be considered [56][57][58][59]. Finally, 2.5% of SMM presented as local or diffuse intramuscular bleeding.…”

Nasal angioma with osseous metaplasia

“…Although bone formation in vascular lesions is very rare, this is reported even at distance from bones. [ 1 5 6 ] The large size of the vascular spaces and vessels along with the limited extension of the intranodular connective tissue (as compared to the vascular component) and without significant inflammation allowed us to eliminate the hypothesis of a posttraumatic hyperplastic granulation tissue reaction. However, an association of ancient reparative lesions cannot completely ruled out.…”