Angiomatous Meningiomas Have a Very Benign Outcome Despite Frequent Peritumoral Edema at Onset

Hua, Lingyang; Luan, Shihai; Li, Haixia; Zhu, Hongda; Liu, Hanqiu; Chen, Xiancheng; Bozinov, Oliver; Xie, Qing; Gong, Yi

doi:10.1016/j.wneu.2017.08.096

Cited by 30 publications

(40 citation statements)

References 24 publications

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“…In the present study, a previously undescribed histological feature was detected, consisting of an increased number of fibrotic tumor vessels, observed after EvG-staining and confirmed in the CD34-staining, showing no association with other histological subtypes. Among grade I meningiomas, well-vascularized histological subtypes like angiomatous meningiomas are rare but have been extensively described [ 18 , 20 , 21 ]. In addition to a high vascular density, they frequently show FTV in their macrovascular subtype.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, VD was shown to be distinctly higher in angiomatous tumors than in other grade I meningioma subtypes in our series. However, in contrast to meningiomas displaying FTV, angiomatous meningiomas are usually characterized by low recurrences rates (1.8–2.1% [ 18 , 20 , 21 ]). Due to the low incidence, in contrast to meningothelial and transitional meningiomas, only four angiomatous meningiomas could be included in our study.…”

Section: Discussionmentioning

confidence: 99%

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Occurrence of Fibrotic Tumor Vessels in Grade I Meningiomas Is Strongly Associated with Vessel Density, Expression of VEGF, PlGF, IGFBP-3 and Tumor Recurrence

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et al. 2020

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Angiogenesis is a key feature during oncogenesis and remains a potential target of antiangiogenic therapy. While commonly described in high-grade lesions, vascularization and its correlation with prognosis in grade I meningiomas is largely unexplored. In the histological classification, not only the number but also the composition of blood vessels seems to be important. Therefore, tumor vessel density and fibrosis were correlated with clinical and imaging variables and prognosis in 295 patients with intracranial grade I meningioma. Expression of pro-angiogenic proteins within the meningiomas was investigated by proteome analyses and further validated by immunohistochemical staining. Fibrotic tumor vessels (FTV) were detected in 48% of all tumors and strongly correlated with vessel density, but not with the histopathological tumor subtype. Occurrence of FTV was correlated with a 2-fold increased risk of recurrence in both univariate and multivariate analyses. Explorative proteome analyses revealed upregulation of VEGF (vascular endothelial growth factor), PlGF (placental growth factor), and IGFBP-3 (insulin-like growth factor-binding protein-3) in tumors displaying FTV. Immunohistochemical analyses confirmed strong correlations between tumor vessel fibrosis and expression of VEGF, PlGF, and IGFBP-3. Presence of FTV was strongly associated with disruption of the arachnoid layer on preoperative MRI in univariate and multivariate analyses. In summary, the occurrence of fibrotic tumor vessels in grade I meningiomas is strongly associated with vessel density, disruption of the arachnoid layer, expression of VEGF, PlGF, IGFBP-3 and tumor recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Occurrence of Fibrotic Tumor Vessels in Grade I Meningiomas Is Strongly Associated with Vessel Density, Expression of VEGF, PlGF, IGFBP-3 and Tumor Recurrence

Heß

Spille

Adeli

et al. 2020

Cancers

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“…Among the population of benign meningioma, there was usually a female predominance [3]. AM is usually characterized by the onset of slow progressive symptoms and the main symptoms result from compression of the adjacent structures.…”

Section: Discussionmentioning

confidence: 99%

“…Few patients showed rapidly progressive symptoms, which may be a reason for the relatively long period between the onset of symptoms and admission time. Like other benign meningiomas, AM can locate in almost all intracranial areas as well as the spine, with cerebral convexity being the most common location [3].…”

Section: Discussionmentioning

confidence: 99%