Angiomyofibroblastoma of the Male Perineum

Abstract

We report a case of angiomyofibroblastoma (AMF)-like tumor of the perineum in a 54-year-old man. The asymptomatic lesion measured 3 cm and appeared as a tan homogeneous mass. Histologically, it appeared as a circumscribed nodular spindle cell proliferation with alternating cellular and hypocellular areas. The spindle cells exhibited minimal nuclear pleomorphism and scanty mitotic activity. Focally, some cells were epithelioid. Large blood vessels were present, with perivascular fibrosis. The spindle cells expressed vimentin, but not desmin, actin, S100, or CD34. These features were similar to those of AMF as initially reported in the vulva. A perineal localion of this lesion in a male has not been reported in the literature, to the best of our knowledge. Int J Surg Pathol 8(1):79-82, 2000

Angiomyofibroblastoma-like tumor of the scrotum: A case report and literature review

“…The current case report presents a case of AMF-like tumor in the scrotum. To the best of our knowledge, only one case of AMF-like tumor of the perineum has been previously reported in the Chinese population of a 54-year-old male by Hlaing and Tse in Hong Kong (4). The purpose of the current study was to expand the experience with AMF-like tumors in males by describing the second case in the Chinese population of this rare lesion with a long period of follow-up and review of the literature.…”