Angiomyofibroma of the nasal cavity; A clinical and electron micrographic study

Abstract

The term angiofibroma commonly conjures up an ingrained mental image in the minds of otolaryngologists. The image is that of an adolescent male with a vascular lesion limited to or extending from the confines of the nasopharynx. This lesion is histologically benign, although it may, at times, prove to be locally destructive. In reviewing the literature, isolated case reports have a p p e a r e d that are histologically compatible with an angiofibroma but may not conform with expected characteristics involving sex, 1-4 age, 1,s,6 or anatomic locations. 6-1~ Reviewers examine these cases with suspicion and orten express outright disbelief as to the validity From the Departments of Otolaryngology (Drs. Hersh and Grimes) and Pathology (Dr. Harrison), Manhattan Eye, Ear and Throat Hospital; and the Department of Ophthalmology (Dr. Iwamoto), New York Hospital.

Juvenile nasopharyngeal angiofibromas in Denmark 1981–2003: diagnosis, incidence, and treatment

“…In many of the papers referred by Gruber, however, the female cases cannot be extracted from the male cases, and therefore cannot be further analyzed. An additional case of a 69-year-old woman was presented by Hersh et al [11]. This patient had a 1 )/1 cm tumor in the nasal cavity.…”

Angiofibroma of the nasal cavity in 13 dogs

“…Notably, a similar disease exists in humans and is referred to as juvenile nasopharyngeal angiofibroma 2 . It most commonly occurs in male adolescents although there are scattered reports of older patients, including females, in the human literature 2–4 . In humans, the masses appear to originate from the posterolateral wall of the nasal cavity in proximity to the superior aspect of the sphenopalatine foramen 2,4 .…”

“…It is best described in young males and is often referred to as juvenile nasal angiofibroma although there are reports of this lesion occurring in older patients, including females 2 . It is a histologically benign, but locally aggressive vascular nasopharyngeal tumour, characterized by a proliferation of irregular appearing blood vessels that are surrounded by a connective tissue stroma 3,4 . These tumours expand intranasally into the nasophyarynx and nasal cavity eroding bone and can invade the infratemporal fossa, orbit and middle cranial fossa.…”

Extranasopharyngeal Angiofibroma Of The Cartilaginous Nasal Septum: Possible Origin From Ectopic Tissue Trapped During Septal Development

“…The term "juvenile NA" was first coined by Chauveau in 1906. 4 Angiofibroma of nasopharynx usually conforms to the specific clinical characteristics with respect to age, sex and site.…”

“…The patients are usually older and more female adults are affected. 4 Herein a case is reported of angiofibroma in 37 year old female, originating from antero-inferior part of cartilaginous nasal septum mimicking bleeding polypus septum and the likely theory of origin is discussed.…”