2008
DOI: 10.3892/mmr_00000020
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Angiopoietin-3 overexpression in tobacco smoke-induced mouse lung tumors and its relation to vitamin E intervention

Abstract: Abstract. Animal studies have shown that tobacco smoke can induce lung cancer in mice,and that the intake of Vitamin E (VE) has a protective effect against its risk. However, the mechanisms of action of VE remain unclear. In this study, DNA microarrays for gene expression profiles of the mouse genome were applied in order to screen for the upregulated genes associated with VE intervention in smoke-induced lung cancer. Real-time PCR was used to validate the screened upregulated angiopoietin-3 gene (Ang-3), and … Show more

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