Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer

Shanmugam, Muthu K.; Warrier, Sudha; Kumar, Alan Prem; Sethi, Gautam; Arfuso, Frank

doi:10.2174/1570161115666170713094319

Cited by 187 publications

(119 citation statements)

References 248 publications

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“…Mother Nature is the origin of 70% of the pharmaceuticals, however, there is a need to explore this vast reserve further for identification of various novel phytochemicals and chemotherapeutic agents for better management of this disease [19,20,21,22,23,24,25,26,27,28,29,30,31,32]. These natural products display inherent anti-cancer properties which emanate from a range of phytochemicals such as alkaloids, diterpenoids, flavonoids, polyphenolic compounds and sesquiterpenes obtained from various medicinal plants, fruits and vegetables [23,27,33,34,35,36,37].…”

Section: Introductionmentioning

confidence: 99%

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Ranaware¹,

Banik

Deshpande³

et al. 2018

IJMS

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138

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The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will increase in future and will create global havoc, designating it as an epidemic. Conventional chemotherapeutics and treatment with synthetic disciplines are often associated with adverse side effects and development of chemoresistance. Thus, discovering novel economic and patient friendly drugs that are safe and efficacious is warranted. Several natural compounds have proved their potential against this dreadful disease so far. Magnolol is a hydroxylated biphenyl isolated from the root and stem bark of Magnolia tree. Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, cervical, colon, liver, lung, prostate, skin, etc. Considering these perspectives, the current review primarily focuses on the fascinating role of magnolol against various types of cancers, and the source and chemistry of magnolol and the molecular mechanism underlying the targets of magnolol are discussed. This review proposes magnolol as a suitable candidate that can be appropriately designed and established into a potent anti-cancer drug.

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Section: Introductionmentioning

confidence: 99%

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Ranaware¹,

Banik

Deshpande³

et al. 2018

IJMS

Self Cite

138

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“…In a malignant tumor, the vasculature helps in tumor cell invasion and migration to distant site organs, which is known as tumor metastasis. Thus, the tumor angiogenesis represents an attractive target for tumor growth inhibition [53]. Vascular endothelial growth factor (VEGF) and its cognate receptor (VEGF receptor 2 [VEGFR-2]) are considered as the most noticeable regulators of angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Antioxidative stress of Chitosan-Gallium Nanoparticles and low doses of γ-irradiation on mice bearing Ehrlich carcinoma

Mohammad¹,

Ahmed²,

Kandil³

et al. 2019

IJASTR

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Guided treatments with nanoparticles and low doses of radiation are a new approach in cancer therapy. This study evaluated the ability of Chitosan-Gallium nanoparticles (Ch.GaNPs) and low dose ofγ-radiation to suppressoxidative stressof female mice bearing solid Ehrlich carcinoma (EC)in the neck region. Begins from 7 th day of EC cells inoculation Ch.GaNPs(0.5 mg/kg body weight) were orally administered via gavages for a period of 15 consecutive days and Whole-body γ -irradiation was carried out at a single dose of 0.25Gy/twice a week for 2 weeks. Tumor size was monitored. Oxidative stress markers were assessed, histopathological changes in tumor and liver tissues were studied. In addition, the angiogenic markers concentrations were evaluated.Treatment of EC-bearing mice with Ch.GaNPs and/or low doseof γ -radiation exposure significantly reduced tumor volume, increased lipid peroxidation and decreased glutathione content as well as glutathione peroxidase activity intumor and liver tissues. Moreover, the dual treatment significantly reducedserumVEGF, PDGF and TNF-α levels, and significantly elevated Cas-3 activity. These results were well appreciated with the histopathologicalfindings in the tumor and liver tissue. In conclusion, the combined treatment of Ch.GaNPs and low dose ofγ-radiation have a role in suppressing oxidative stress of female mice bearing solid Ehrlich carcinoma .

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“…Further, recent reports suggest that intraoral and oropharyngeal tumors occur and inexpensive for treating this neoplasm Kunnumakkara et al, 2019a). Numerous epidemiological, clinical, and experimental studies suggest that natural products possess enormous therapeutic potential for the prevention and treatment of different malignancies (Deorukhkar et al, 2007;Pandey et al, 2007;Shanmugam et al, 2011a;Yang et al, 2013;Dai et al, 2015a;Hsieh et al, 2015;Roy et al, 2016;Shanmugam et al, 2016;Yarla et al, 2016;Hasanpourghadi et al, 2017;Shanmugam et al, 2017;Banik et al, 2018;Jayasooriya et al, 2018;Khwairakpam et al, 2018;Kunnumakkara et al, 2019b). For instance, various plant polyphenols have been suggested to inhibit tumorigenesis and carcinogenesis of skin, liver, colon and lung cells (Lambert et al, 2005;Tan et al, 2010;Rajendran et al, 2011a;Rajendran et al, 2011b;Chan et al, 2012;Rajendran et al, 2012;Manu et al, 2013;Subramaniam et al, 2013;Sethi et al, 2014;Siveen et al, 2014a;Tang et al, 2014;Dai et al, 2015b;Lee et al, 2015;Amararathna et al, 2016;Dai et al, 2016;Ko et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

An Investigation on the Therapeutic Potential of Butein, A Tretrahydroxychalcone Against Human Oral Squamous Cell Carcinoma

Bordoloi

Monisha

Roy

et al. 2019

Asian Pac J Cancer Prev

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Background: Oral squamous cell carcinoma (OSCC) is one of the most predominant cancers in India. With advances in the field of oncology, a number of therapies have emerged; however, they are minimally effective. Consequently, there is a need to develop safe and effective regimens for the treatment of OSCC. Butein, a tetrahydroxychalcone has been found to exhibit potent antioxidant, anti-inflammatory, and also anti-tumor effects against several cancer types. However, its effect on OSCC is not studied yet. Methods: The effect of butein on the viability, apoptosis, migration and invasion of OSCC cells was evaluated using MTT, colony formation, PI/FACS, live and dead, scratch wound healing, and matrigel invasion assays. Further Western blot analysis was done to evaluate the expression of different proteins involved in the regulation of cancer hallmarks. Results: This is the first report exemplifying the anti-cancer effect of butein against OSCC. Our results showed that butein exhibited potent anti-proliferative, cytotoxic, anti-migratory, and anti-invasive effects in OSCC cells. It suppressed the expression of NF-κB and NF-κB-regulated gene products such as COX-2, survivin and MMP-9 which are involved in the regulation of different processes like proliferation, survival, invasion, and metastasis of OSCC cells. Conclusion Collectively, these results suggest that butein has immense potential in the management of OSCC. Nonetheless, in vivo validation is critical before moving to clinical trials.

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Potential Role of Natural Compounds as Anti-Angiogenic Agents in Cancer

Cited by 187 publications

References 248 publications

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Antioxidative stress of Chitosan-Gallium Nanoparticles and low doses of γ-irradiation on mice bearing Ehrlich carcinoma

An Investigation on the Therapeutic Potential of Butein, A Tretrahydroxychalcone Against Human Oral Squamous Cell Carcinoma

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