Angiopoietin‐Tie signaling in kidney diseases: an updated review

He, Fang-Fang; Zhang, Di; Chen, Qing; Zhao, Yuxi; Wu, Liang; Li, Zhenqiong; Zhang, Chun; Jiang, Zhaohua; Wang, Yumei

doi:10.1002/1873-3468.13568

Cited by 27 publications

(17 citation statements)

References 86 publications

(178 reference statements)

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“…Angiopoietins (Angpts) are angiogenic and endothelial-specific growth factors that act through tyrosine kinase with immunoglobulin-like and EGF-like domain (Tie) 1 (Tie1) and Tie2 receptors on endothelial cells (reviewed in [115]). Angpt1 and 2 are VEGF cofactors with complementary functions regarding vascular homeostasis [116].…”

Section: Glomerular and Microvascular Growth And Patterningmentioning

confidence: 99%

Role of the renin–angiotensin system in kidney development and programming of adult blood pressure

et al. 2020

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Adverse events during fetal life such as insufficient protein intake or elevated transfer of glucocorticoid to the fetus may impact cardiovascular and metabolic health later in adult life and are associated with increased incidence of type 2 diabetes, ischemic heart disease and hypertension. Several adverse factors converge and suppress the fetal renin-angiotensin-aldosterone system (RAAS). The aim of this review is to summarize data on the significance of RAAS for kidney development and adult hypertension. Genetic inactivation of RAAS in rodents at any step from angiotensinogen to angiotensin II (ANGII) type 1 receptor (AT 1 ) receptors or pharmacologic inhibition leads to complex developmental injury to the kidneys that has also been observed in human case reports. Deletion of the 'protective' arm of RAAS, angiotensin converting enzyme (ACE) 2 (ACE-2) and G-protein coupled receptor for Angiotensin 1-7 (Mas) receptor does not reproduce the AT 1 phenotype. The changes comprise fewer glomeruli, thinner cortex, dilated tubules, thicker arterioles and arteries, lack of vascular bundles, papillary atrophy, shorter capillary length and volume in cortex and medulla. Altered activity of systemic and local regulators of fetal-perinatal RAAS such as vitamin D and cyclooxygenase (COX)/prostaglandins are associated with similar injuries. ANGII-AT 1 interaction drives podocyte and epithelial cell formation of vascular growth factors, notably vascular endothelial growth factor (VEGF) and angiopoietins (Angpts), which support late stages of glomerular and cortical capillary growth and medullary vascular bundle formation and patterning. RAAS-induced injury is associated with lower glomerular filtration rate (GFR), lower renal plasma flow, kidney fibrosis, up-regulation of sodium transporters, impaired sodium excretion and salt-sensitive hypertension. The renal component and salt sensitivity of programmed hypertension may impact dietary counseling and choice of pharmacological intervention to treat hypertension.

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Section: Glomerular and Microvascular Growth And Patterningmentioning

confidence: 99%

Role of the renin–angiotensin system in kidney development and programming of adult blood pressure

et al. 2020

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“…ANGPT2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies (76). The release of ANGPT2 into the bloodstream is triggered by hypoxia, inflammation and high glucose levels (77). ANGPT2 is crucial to the induction of inflammation and sensitizes endothelial cells to TNF-α (78).…”

Section: Discussionmentioning

confidence: 99%

Multi-scalar data integration links glomerular angiopoietin-tie signaling pathway activation with progression of diabetic kidney disease

Nair

Zhao

Chang

et al. 2021

Preprint

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Diabetes is the leading cause of chronic kidney disease. Prognostic biomarkers reflective of underlying molecular mechanisms are critically needed for effective management of diabetic kidney disease (DKD). In the Clinical Phenotyping and Resource Biobank study, an unbiased, machine learning approach identified a three-marker panel from plasma proteomics which, when added to standard clinical parameters, improved the prediction of outcome of end-stage kidney disease (ESKD) or 40% decline in baseline glomerular filtration rate (GFR) in a discovery DKD group (N=58) and was validated in an independent group (N=68) who also had kidney transcriptomic profiles available. Of the three markers, plasma angiopoietin 2 (ANGPT2) remained significantly associated with composite outcome in 210 Chinese Cohort Study of Chronic Kidney Disease participants with DKD. The glomerular transcriptional Angiopoietin/Tie (ANG-TIE) activation scores, derived from the expression of 154 literature-curated ANG-TIE signaling mediators, positively correlated with plasma ANGPT2 levels and outcome, explained by substantially higher TEK receptor expression in glomeruli and higher ANG-TIE activation scores in endothelial cells in DKD by single cell RNA sequencing. Our work suggests that activation of glomerular ANG-TIE signaling in the kidneys underlies the association of plasma ANGPT2 with disease progression, thereby providing potential targets to prevent DKD progression.

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“…Meanwhile, hyperfiltration and renal morphology were unchanged, indicating a still limited role (90). The role of angiopoietins in DKD has been nicely reviewed elsewhere (91,92). Overall, the authors consider that angiopoietins are produced by podocyte and signal via TIE2 in endothelial cells only, which is most likely the mechanism but has not been entirely demonstrated.…”

Section: Other Influences Of Podocytes On Glomerular Ecsmentioning

confidence: 99%

Glomerular Endothelial Cell Crosstalk With Podocytes in Diabetic Kidney Disease

2021

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Diabetes is the main cause of renal failure worldwide. Complications of the kidney micro-and macro-circulation are common in diabetic patients, leading to proteinuria and can progress to end-stage renal disease. Across the complex interplays aggravating diabetes kidney disease progression, lesions of the glomerular filtration barrier appear crucial. Among its components, glomerular endothelial cells are known to be central safeguards of plasma filtration. An array of evidence has recently pinpointed its intricate relations with podocytes, highly specialized pericytes surrounding glomerular capillaries. During diabetic nephropathy, endothelial cells and podocytes are stressed and damaged. Besides, each can communicate with the other, directly affecting the progression of glomerular injury. Here, we review recent studies showing how in vitro and in vivo studies help to understand pathological endothelial cells-podocytes crosstalk in diabetic kidney disease.

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Angiopoietin‐Tie signaling in kidney diseases: an updated review

Cited by 27 publications

References 86 publications

Role of the renin–angiotensin system in kidney development and programming of adult blood pressure

Role of the renin–angiotensin system in kidney development and programming of adult blood pressure

Multi-scalar data integration links glomerular angiopoietin-tie signaling pathway activation with progression of diabetic kidney disease

Glomerular Endothelial Cell Crosstalk With Podocytes in Diabetic Kidney Disease

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