Angiosarcoma of the breast: a 30 year perspective with an optimistic outlook

Georgiannos, Stavros N; Sheaff, Michael

doi:10.1016/s0007-1226(03)00025-0

Cited by 46 publications

(39 citation statements)

References 22 publications

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“…Amongst our patients, it was more common in the left breast (7 out of 11 vs. 4). Fast-growing breast lump with edema, usually not tender during palpation, was the most prominent physical examination feature, which is in line with that reported in the literature 10 . In the majority of patients, the primary tumour was at least 5 cm in size, which is associated with unfavourable prognosis and shorter disease-free survival related to the presence of distant metastases 11 .…”

Section: Discussionsupporting

confidence: 90%

Primary Angiosarcoma of the Breast—Series of 11 Consecutive Cases—A Single-Centre Experience

et al. 2018

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Angiosarcomas of the breast are rare parenchymal malignancies of the chest wall. Surgery is the main treatment modality with chemotherapy and radiotherapy used in case of recurrence. With generally unfavourable prognosis and lack of clear treatment guidelines due to its rarity and scarcity of available data, angiosarcoma of the breast is a challenging clinical situation for both oncologist and patient. We present here the results of a series of 11 consecutive primary angiosarcoma cases treated at our institute between 2000 and 2015.

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Section: Discussionsupporting

confidence: 90%

Primary Angiosarcoma of the Breast—Series of 11 Consecutive Cases—A Single-Centre Experience

et al. 2018

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“…During a skin biopsy, the specimen should be taken from the darkest and most infiltrated area [70]. Bruising of the skin may also be evident [71]. However, skin alterations and fibrosis are typical in radiated areas.…”

Section: Diagnosismentioning

confidence: 99%

“…Most RIS tumors were high-grade, with some having heterogeneity in their grade [71]. De Smet et al [10] reported that 80% of RIS tumors, but only 40% of primary sarcoma tumors, were high grade (grade 3 per the AJCC staging system).…”

Section: Prognosismentioning

confidence: 99%

Radiation-Induced Sarcoma of the Breast: A Systematic Review

et al. 2012

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After completing this course, the reader will be able to:1. Evaluate the level of evidence to inform decision making for the treatment radiation induced sarcoma of the breast.2. Explain diagnostic criteria for radiation-induced sarcoma.3. Describe the effectiveness of surgery, chemotherapy and radiation therapy for radiation induced sarcoma of the breast.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME ABSTRACTIntroduction. Radiation-induced sarcoma (RIS) is a rare, aggressive malignancy. Breast cancer survivors treated with radiotherapy constitute a large fraction of RIS patients. To evaluate evidenced-based practices for RIS treatment, we performed a systematic review of the published English-language literature. Methods. We performed a systematic keyword search of PubMed for original research articles pertaining to RIS of the breast. We classified and evaluated the articles based on hierarchal levels of scientific evidence.Results. We identified 124 original articles available for analysis, which included 1,831 patients. No randomized controlled trials involving RIS patients were found. We

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“…Primary angiosarcoma affects relatively younger patients usually at the age of 20-50 years [2]. Patient with primary angiosarcoma may have an insidious onset, usually presents as a palpable mass without pain and with history of rapidly growing size [3]. The tumours which are large and superficial often present with purple blue skin discolouration.…”

Section: Discussionmentioning

confidence: 99%