Angiosuppressive effects of bio-fabricated silver nanoparticles synthesis using Clitoria ternatea flower: an in vitro and in vivo approach

Srinivas, Balaji Kyathegowdanadoddi; Shivamadhu, Madhu Chakkere; Siddappaji, Kiran Kumar; Krishnappa, Dharmappa Kattepura; Jayarama, Shankar

doi:10.1007/s00775-019-01721-x

Cited by 18 publications

(5 citation statements)

References 28 publications

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“…The absorption spectra of both the flower extract of Clitoria ternatea and ctGQDs were predicted and are shown in Figure . The absorption band of the flower extract shows various peaks at 340, 490, and 545 nm due to the presence of various chemical constituents like p -caumaric acid, taraxerol, daphidin-3,5-diglucoside, and daphidin-3β-diglucoside, , whereas the absorption band of the ctGQDs demonstrates a definite surface Plasmon’s resonance spectra centered at 320 nm, which confirms the synthesis of graphene quantum dots, and the peak at 320 nm indicates that in the carbon structure n−π* electronic transition occurs.…”

Section: Resultsmentioning

confidence: 99%

Clitoria ternatea Mediated Synthesis of Graphene Quantum Dots for the Treatment of Alzheimer’s Disease

Tak

Sharma

Dave

et al. 2020

ACS Chem. Neurosci.

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The main purpose of the present study was to synthesize graphene quantum dots (GQDs)from the flowers of Clitoria ternatea with the help of one-pot microwave-assisted green synthesis for the treatment of Alzheimer's disease. Further, the synthesized graphene quantum dots show a particle size of 10 nm ±1.3, a PDI of 0.354 ± 1.8, and a ζ potential of −46 ± 0.4, indicating the good stability of the quantum dots. With the help of scanning electron microscopy (SEM) and transfer electron microscopy (TEM) examination, the surface microscopic behavior of the synthesized quantum dots was determined. The presence of functional groups in the quantum dots was determined by Fouriertransform infrared spectroscopy (FTIR) study, the chemical state information on the sample was determined with the help of X-ray photoelectron spectroscopy (XPS), and the surface area of the dots was determined with the help of a surface area analyzer. With the help of a radial arm maze and water morris maze assay, the learning and memory capacity of the quantum dots was assessed, and the results show that the ctGQDs significantly decreased the transfer latency to reach the baited arm in 10.37 ± 1.65 s or to the hidden platform in 18.42 ± 0.99 s in 7 days. The synthesized quantum dots show more inhibition of the acetyl cholinesterase enzyme, i.e., 86.32 ± 1.52%, as compared to that of pure donepezil, i.e., 72.46 ± 2.21%. ctGQDs considerably increased the level of glutathione and protein and decreased the level of lipid peroxide and nitric oxide. The histopathological image of ctGQDs shows more preservation of small pyramidal cell and treats the disorganization of the cells. These results suggest that the quantum dots significantly crossed the blood−brain barrier since they were small in size and were effective in reducing Alzheimer-like symptoms in rodents, and thus, it can be concluded that Clitoria ternatea flowers can be used as an adjuvant in the treatment of Alzheimer's.

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Section: Resultsmentioning

confidence: 99%

Clitoria ternatea Mediated Synthesis of Graphene Quantum Dots for the Treatment of Alzheimer’s Disease

Tak

Sharma

Dave

et al. 2020

ACS Chem. Neurosci.

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“…Bunga telang memiliki manfaat sebagai antiarthritis, antialergi antioksidan, antitusif dan antikanker (Adhikary et al, 2018;Iamsaard et al, 2014;Singh et al, 2018;Srinivas et al, 2019). Berdasarkan penelitain uji klinis antosianin bermanfaat didalam tubuh seperti meningkatkan HDL dan menurunkan LDL pada pasien dislipidemik, mengurangi risiko infark miokard dan risiko penyakit kardiovaskuler (Intuyod et al, 2014).…”

Section: Pendahuluanunclassified

Pendampingan Pemanfaatan Jahe Dan Bunga Telang Sebagai Minuman Serbuk Fungsional Di Desa Ulak Kerbau Baru Tanjung Raja

Agustiarini,

Hasanudin,

Hendri

et al. 2024

JAI

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Jahe dan bunga telang merupakan tanaman yang banyak terdapat di Desa Ulak Kerbau Baru Tanjung Raja. Jahe memiliki manfaat yaitu antioksidan, antiemetik, antiinflamasi sedangkan bunga telang memiliki khasiat sebagai antioksidan, antikanker,antitusive dan alegi.Jahe dan bunga telang memiliki banyak manfaat bagi kesehatan yang dapat dikembangkan menjadi minuman serbuk fungsional. Tujuan pengabdian masyarakat ini yaitu meningkatkan pengetahuan, pemahaman dan keterampilan masyarakat dalam memanfaatkan jahe dan bunga telang menjadi produk minuman serbuk fungsional yang memiliki kualitas baik dan bermanfaat bagi kesehatan. Tahap pengabdian masyarakat yaitu persiapan, pelaksanaan dan evaluasi. Tahap persiapan di mulai dengan observasi, diskusi penyusunan program kegiatan, pembuatan materi dan soal pretest postest. Pada tahap pelaksanaan diawali dengan pembukaan dan perkenalan tim pengabdian Masyarakat dan pemberian materi serta praktek langsung.Kegiatan pengabdian masyarakat yang dilakukan diterima dengan baik dan antusias masyarakat sangat tinggi. Pada kegiatan yang dilakukan ini terjadi peningkatan pengetahuan dan pemahaman masyarakat tentang jahe dan bunga telang, pengukuran peningkatan dilakukan dengan melihat nilai pretest (71,8) dan postest (85,4). Peserta Pengabdian masyarakat mengungkapkan kegiatan ini sangat bermanfaat dan dapat menjadikan ide pembuatan produk inovasi rumah tangga dengan memanfaatkan tanaman disekitar rumah sebagai produk yang memiliki manfaat bagi kesehatan.Pengabdian masyarakat ini juga meningkatkan keterampilan dalam mengelola jahe dan bunga telang sebagai minuman serbuk fungsional yang memiliki kualitas yang baik dan bermanfaat bagi kesehatan.Kegiatan pengabdian masyarakat ini dapat meningkatkan pengetahuan, pemahaman dan keterampilan masyarakat dalam memanfaatkan jahe dan bunga telang menjadi produk minuman serbuk fungsional.

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“…Salehi et al showed multifunctional biomedical application (anticancer, antioxidant, and antibacterial properties) of biosynthesized AgNPs using Artemisia marschalliana Sprengel aerial part extract [63]. Srinivas et al demonstrated the suppression of tumor angiogenesis (determined by VEGF quantification, microvessel density counts, and CAM assays) using the biosynthesized AgNPs by Clitoria ternatea flower extract toward various in vitro and in vivo mouse (Ehrlich-Lettre ascites carcinoma: EAC) models [69]. Detailed mechanistic studies revealed that AgNPs inhibited the cellular density and ascites secretion, which in turn cause apoptosis.…”

Section: Biosynthesized Silver Nanoparticles In Cancer Theranostics: Recent Advancements and Patentsmentioning

confidence: 99%

Biosynthesized Gold and Silver Nanoparticles in Cancer Theranostics

Nethi¹,

Mukherjee²,

Mukherjee³

2020

Handbook of Nanomaterials and Nanocomposites for Energy and Environmental Applications

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Nanoparticles have gained immense attention in cancer theranostic application due to their unusual physicochemical properties at the nanoscale. Green nanotechnology has generated an alternative option for eco-friendly synthesis of nanoparticles that show less toxicity and high efficacy. Biosynthesized gold and silver nanoparticles demonstrated various biomedical applications including Susheel Kumar Nethi and Anubhab Mukherjee contributed equally with all other contributors.

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Angiosuppressive effects of bio-fabricated silver nanoparticles synthesis using Clitoria ternatea flower: an in vitro and in vivo approach

Cited by 18 publications

References 28 publications

Clitoria ternatea Mediated Synthesis of Graphene Quantum Dots for the Treatment of Alzheimer’s Disease

Clitoria ternatea Mediated Synthesis of Graphene Quantum Dots for the Treatment of Alzheimer’s Disease

Pendampingan Pemanfaatan Jahe Dan Bunga Telang Sebagai Minuman Serbuk Fungsional Di Desa Ulak Kerbau Baru Tanjung Raja

Biosynthesized Gold and Silver Nanoparticles in Cancer Theranostics

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