Angiotensin-(1–7) ameliorates intestinal barrier dysfunction by activating the Keap1/Nrf2/HO-1 signaling pathway in acute pancreatitis

Gu, Ruolei; Cui, Tianyu; Guo, Yesong; Luan, Ying-yi; Wang, Xueran; Liu, Ruixia; Yin, Chenghong

doi:10.1007/s11033-023-08544-9

Mol Biol Rep

2023

DOI: 10.1007/s11033-023-08544-9

|View full text |Cite

Angiotensin-(1–7) ameliorates intestinal barrier dysfunction by activating the Keap1/Nrf2/HO-1 signaling pathway in acute pancreatitis

Ruolei Gu

Tianyu Cui

Yesong Guo

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Angiotensin‐(1–7) improves intestinal microbiota disturbances and modulates fecal metabolic aberrations in acute pancreatitis

Gu,

Wei,

Cui

et al. 2024

The FASEB Journal

View full text Add to dashboard Cite

Acute pancreatitis (AP) is a serious health problem that dysregulates intestinal microbiota. Angiotensin (Ang)‐(1–7) plays a protective role in the intestinal barrier in AP, but its effect on intestinal microbiota remains clear. To investigate the impact of Ang‐(1–7) on AP‐induced intestinal microbiota disorder and metabolites. We collected blood and fecal samples from 31 AP patients within 48 h after admission to the hospital, including 11 with mild AP (MAP), 14 with moderately severe AP (MSAP), six with severe AP (SAP). Mice were divided into four groups: control, AP, AP + Ang‐(1–7) via tail vein injection, and AP + Ang‐(1–7) via oral administration. The samples of mice were collected 12 h after AP. Pancreatic and intestinal histopathology scores were analyzed using the Schmidt and Chiu scores. Fecal microbiota and metabolites analysis was performed via 16S rDNA sequencing and nontargeted metabolomics analysis, respectively. In patients, the abundance of beneficial bacteria (Negativicutes) decreased and pathogenic bacteria (Clostridium bolteae and Ruminococcus gnavus) increased in SAP compared with MAP. Ang‐(1–7) levels were associated with changes in the microbiota. There were differences in the intestinal microbiota between control and AP mice. Ang‐(1–7) attenuated intestinal microbiota dysbiosis in AP mice, reflecting in the increase in beneficial bacteria (Odoribacter and Butyricimonas) than AP, as well as pancreatic and intestinal injuries. Oral administration of Ang‐(1–7) reversing AP‐induced decreases in metabolisms: secondary bile acids, emodin, and naringenin. Ang‐(1–7) may improve intestinal microbiota dysbiosis and modulate fecal metabolites in AP, thereby reducing the damage of AP.

show abstract

Angiotensin‐(1–7) improves intestinal microbiota disturbances and modulates fecal metabolic aberrations in acute pancreatitis

Gu,

Wei,

Cui

et al. 2024

The FASEB Journal

View full text Add to dashboard Cite

show abstract

The Effect of Protein Nutritional Support on Inflammatory Bowel Disease and Its Potential Mechanisms

Li,

Wang

2024

Nutrients

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD), a complex chronic inflammatory bowel disorder that includes Crohn’s disease (CD) and Ulcerative Colitis (UC), has become a globally increasing health concern. Nutrition, as an important factor influencing the occurrence and development of IBD, has attracted more and more attention. As the most important nutrient, protein can not only provide energy and nutrition required by patients, but also help repair damaged intestinal tissue, enhance immunity, and thus alleviate inflammation. Numerous studies have shown that protein nutritional support plays a significant role in the treatment and remission of IBD. This article presents a comprehensive review of the pathogenesis of IBD and analyzes and summarizes the potential mechanisms of protein nutritional support in IBD. Additionally, it provides an overview of the clinical effects of protein nutritional support in IBD and its impact on clinical complications. Research findings reveal that protein nutritional support demonstrates significant benefits in improving clinical symptoms, reducing the risk of complications, and improving quality of life in IBD patients. Therefore, protein nutritional support is expected to provide a new approach for the treatment of IBD.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Angiotensin-(1–7) ameliorates intestinal barrier dysfunction by activating the Keap1/Nrf2/HO-1 signaling pathway in acute pancreatitis

Cited by 2 publications

References 38 publications

Angiotensin‐(1–7) improves intestinal microbiota disturbances and modulates fecal metabolic aberrations in acute pancreatitis

Angiotensin‐(1–7) improves intestinal microbiota disturbances and modulates fecal metabolic aberrations in acute pancreatitis

The Effect of Protein Nutritional Support on Inflammatory Bowel Disease and Its Potential Mechanisms

Contact Info

Product

Resources

About