Angiotensin‐converting enzyme 2 rs2285666 polymorphism and clinical parameters as the determinants of COVID‐19 severity in Iranian population

Khalilzadeh, Fereshteh; Sakhaee, Fatemeh; Sotoodehnejadnematalahi, Fattah; Zamani, Mohammad Saber; Ahmadi, Iraj; Anvari, Enayat; Fateh, Abolfazl

doi:10.1111/iji.12598

Cited by 20 publications

(8 citation statements)

References 36 publications

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“…The COVID-19 mortality toll was the highest in the elderly, obese, male, immunocompromised, tobacco users, chronic disease patients, socioeconomically disadvantaged, black people, and cancer [1,2]. Additionally, interindividual genetic differences could be a factor in COVID-19 cases that are more severe [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants

2023

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Background Polymorphisms in the interleukin-10 (IL10) gene have been linked to the severity of the patients infected with the viral infections. This study aimed to assess if the IL10 gene polymorphisms rs1800871, rs1800872, and rs1800896 were linked to coronavirus disease 19 (COVID-19) mortality in different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in the Iranian population. Methods For genotyping IL10 rs1800871, rs1800872, and rs1800896, this study used the polymerase chain reaction-restriction fragment length polymorphism method in 1,734 recovered and 1,450 deceased patients. Results The obtained finding indicated IL10 rs1800871 CC genotype in the Alpha variant and CT genotype in the Delta variant had a relationship with COVID-19 mortality; however, there was no association between rs1800871 polymorphism and the Omicron BA.5 variant. The COVID-19 mortality rate was associated with IL10 rs1800872 TT genotype in the Alpha and Omicron BA.5 variants and GT in the Alpha and Delta variants. The COVID-19 mortality rate was associated with IL10 rs1800896 GG and AG genotypes in the Delta and Omicron BA.5; nevertheless, there was no association between rs1800896 polymorphism with the Alpha variant. According to the obtained data, the GTA haplotype was the most common of haplotype in different SARS-CoV-2 variants. The TCG haplotype was related to COVID-19 mortality in the Alpha, Delta and Omicron BA.5 variants. Conclusion The IL10 polymorphisms had an impact on COVID-19 infection, and these polymorphisms had different effects in various SARS-CoV-2 variants. To verify the obtained results, further studies should be conducted on various ethnic groups.

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Section: Introductionmentioning

confidence: 99%

Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants

2023

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“…Cathelicidin LL-37 and human β defensin 2 are 25-hydroxyvitamin D–inducible antimicrobial peptides that bind to the SARS-CoV-2 spike protein and prevent viral binding to the cellular receptor angiotensin converting enzyme 2 (ACE2) [ 8 ]. Several bodies of research examining possible links between higher 25-hydroxyvitamin D status or vitamin D supplement use and decreased risk of SARS-CoV-2 infection have produced conflicting findings, with some indicating protective relationships and others indicating null or adverse associations [ 9 , 10 , 11 , 12 , 13 ]. Generally, meta-analyses that include these and other observational research indicate protective relationships [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Role of BglI rs739837 and TaqI rs731236 Polymorphisms in Vitamin D Receptor with SARS-CoV-2 Variants Mortality Rate

Albu-Mohammed

Anvari

Fateh

2022

Genes

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A lack of vitamin D is a potential risk factor for coronavirus disease (COVID-19). Variants in the Vitamin D Receptor (VDR) gene, such as BglI rs739837 and TaqI rs731236, are associated with various viral infection progressions. This study aimed to evaluate the relationship between the BglI rs739837 and TaqI rs731236 polymorphisms and the mortality rate of COVID-19 based on severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) variants. The genotyping of BglI rs739837 and TaqI rs731236 genotypes was analyzed using the polymerase chain reaction–restriction fragment length polymorphism in 1734 improved and 1450 deceased patients positive for SARS-CoV-2. In this study, the rate of COVID-19 mortality was correlated with TaqI rs731236 TC and CC in the α variant and with TaqI rs731236 CC in the Delta variant, whereas no relationship was found in the Omicron BA.5 variant. In addition, the rate of COVID-19 mortality was associated with BglI rs739837 GT and TT in the Omicron BA.5 variant, while there was no association between BglI rs739837 and COVID-19 mortality in the α and Delta variants. The TG haplotype was more common in all SARS-CoV-2 variants, while the CT haplotype was associated with COVID-19 mortality in the Delta and Omicron BA.5 variants. In conclusion, this study indicated that the impacts of BglI rs739837 and TaqI rs731236 polymorphisms were related to SARS-CoV-2 variants. However, further research is still needed to approve our findings.

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“…However, vitamin D controls its level in the body by limiting the amount of proinflammatory cytokines and chemokines released by macrophages. Therefore, it should not be surprising that several studies found a link between vitamin D deficiency and COVID‐19 cases and a higher risk of death (Ahmadi et al, 2022; Gholami et al, 2022; Ilie et al, 2020; Khalilzadeh et al, 2022; Mirzaei Gheinari et al, 2022; Raheem Juhi Al‐Kaabi et al, 2022; Rahimi et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Relationship between CDX2 rs11568820 and EcoRV rs4516035 polymorphisms on the vitamin D receptor gene with susceptibility to different SARS‐CoV‐2 variants

Al‐Mohammedawi,

Anvari,

Fateh

2023

Cell Biology International

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Several studies have revealed that vitamin D deficiency is linked to an increased risk of developing coronavirus disease 19 (COVID‐19). In individuals with the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infections, vitamin D receptor activation is required to decrease acute respiratory distress syndrome. The purpose of this study was to examine the genotypic distribution and allelic frequencies of CDX2 rs11568820 and EcoRV rs4516035 polymorphisms in COVID‐19 patients with various SARS‐CoV‐2 variants. For genotyping of CDX2 rs11568820 and EcoRV rs4516035 polymorphisms, we used the polymerase chain reaction‐restriction fragment length polymorphism technique in 1734 and 1450 recovered and deceased patients, respectively. The results indicated the rate of COVID‐19 mortality was associated with CDX2 rs11568820 AA and GA genotypes in the Delta variant and with CDX2 rs11568820 AA in the Omicron BA.5 variant, while no association was shown in the Alpha variant. Therefore, the rate of COVID‐19 mortality was associated with EcoRV rs4516035 TC and CC genotypes in the Delta variant, while no association was shown in the Alpha and Omicron BA.5 variants. According to our analysis, the T‐G haplotype was more common in all SARS‐CoV‐2 variants. The C‐A haplotype was associated with COVID‐19 mortality in the Delta and Omicron BA.5 variants, and the T‐A haplotype was related to the Alpha variant. In conclusion, the genotype frequencies of the CDX2 rs11568820 and EcoRV rs4516035 polymorphisms between SARS‐CoV‐2 variants were significantly different between the deceased patients and recovered patients. However, more studies should be done to confirm the results.

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Angiotensin‐converting enzyme 2 rs2285666 polymorphism and clinical parameters as the determinants of COVID‐19 severity in Iranian population

Cited by 20 publications

References 36 publications

Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants

Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants

Evaluating the Role of BglI rs739837 and TaqI rs731236 Polymorphisms in Vitamin D Receptor with SARS-CoV-2 Variants Mortality Rate

Relationship between CDX2 rs11568820 and EcoRV rs4516035 polymorphisms on the vitamin D receptor gene with susceptibility to different SARS‐CoV‐2 variants

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