Angiotensin-converting enzyme gene polymorphism and respiratory muscle function in infants

Dimitriou, Gabriel; Papakonstantinou, Despina; Stavrou, Eleana F.; Tzifas, Sotirios; Vervenioti, Aggeliki; Athanassiadou, Aglaia; Mantagos, Stefanos

doi:10.1002/ppul.21316

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…Our study reconfirmed the range of values of TTI mus reported in previous studies and complemented the literature with novel, previously unreported parameters that determine TTI mus , such as the state of skeletal muscularity and the effect of aerobic exercise on the respiratory muscles in healthy children. Given the reported impact of genetic polymorphisms on respiratory muscle function, 8 another strength of our study is that it is the first to report normal values of TTI mus in healthy southern European, predominantly Greek, children.…”

Section: Discussionmentioning

confidence: 82%

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Determinants of inspiratory muscle function in healthy children

Dassios

Dimitriou

2019

Journal of Sport and Health Science

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Background Children are affected by disorders that have an impact on the respiratory muscles. Inspiratory muscle function can be assessed by means of the noninvasive tension–time index of the inspiratory muscles (TTI mus ). Our objectives were to identify the determinants of TTI mus in healthy children and to report normal values of TTI mus in this population. Methods We measured weight, height, upper arm muscle area (UAMA), and TTI mus in 96 children aged 6–18 years. The level and frequency of aerobic activity was assessed by questionnaire. Results TTI mus was significantly lower in male subjects (0.095 ± 0.038, mean ± SD) compared with female subjects (0.126 ± 0.056) ( p = 0.002). TTI mus was significantly lower in regularly exercising (0.093 ± 0.040) compared with nonexercising subjects (0.130 ± 0.053) ( p < 0.001). TTI mus was significantly negatively related to age ( r = −0.239, p = 0.019), weight ( r = −0.214, p = 0.037), height ( r = −0.355, p < 0.001), and UAMA ( r = −0.222, p = 0.030). Multivariate logistic regression analysis revealed that height and aerobic exercise were significantly related to TTI mus independently of age, weight, and UAMA. The predictive regression equation for TTI mus in male subjects was TTI mus = 0.228 − 0.001 × height (cm), and in female subjects it was TTI mus = 0.320 − 0.001 × height (cm) . Conclusion Gender, age, anthropometry, skeletal muscularity, and aerobic exercise are significantly associated with indices of inspiratory muscle function in children. Normal values of TTI mus in healthy children are reported.

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Section: Discussionmentioning

confidence: 82%

“…Impaired respiratory muscle function has been identified as an independent predictor of extubation outcome in children 6 . Furthermore, anthropometry, 7 genetic polymorphisms, 8 and aerobic exercise9, 10 also contribute to respiratory muscle function in children.…”

Section: Introductionmentioning

confidence: 99%

Determinants of inspiratory muscle function in healthy children

Dassios

Dimitriou

2019

Journal of Sport and Health Science

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“…En experiencias previas Dimitriou et al (2010a), determinaron en 110 infantes asistidos por ventilación mecánica, un aumento significativo de la ECA circulante en el genotipo Del/ Del sobre el Ins/Del e Ins/Ins, además de una relación significativa mayor del genotipo Del/Del con la PIM. Paralelamente, en el mismo año, el mismo grupo de investigadores (Dimitriou et al, 2010b) analizó a 132 lactantes en ventilación mecánica, en este grupo encontró una disminución significativa del índice presión-tiempo de la musculatura inspiratoria en el genotipo Ins/Ins con respecto al Ins/Del y Del/Del.…”

Section: Discussionunclassified

Influencia del Polimorfismo Inserción / Deleción (rs4646994) del Gen de la Enzima Convertidora de Angiotensina en la Presión Inspiratoria y Espiratoria Máxima de Jóvenes Chilenos Sedentarios

2017

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MUÑOZ, C. R.; BECERRA, M. S. & PACHECO, V. A.Influencia del polimorfismo inserción/deleción (rs4646994) del gen de la enzima convertidora de angiotensina en la presión inspiratoria y espiratoria máxima de jóvenes chilenos sedentarios. Int. J. Morphol., 35(4):1254Morphol., 35(4): -1260Morphol., 35(4): , 2017. RESUMEN:La expresión de los genes puede impactar sobre el rendimiento muscular. En este aspecto el polimorfismo del gen de la Enzima Convertidora de Angiotensina (ECA), dependiendo de su inserción (Ins) o deleción (Del) puede potenciar diferentes cualidades musculares. Del mismo modo, si consideramos la ventilación como un proceso vital, sería relevante investigar si existe una influencia de este polimorfismo sobre los músculos que llevan a cabo tan importante función. El objetivo de este trabajo consistió en determinar el rendimiento muscular inspiratorio y espiratorio según alelos y polimorfismos del gen de la ECA. Se sometió a 83 sujetos (18 a 35 años), 46 hombres y 37 mujeres, a evaluaciones de capacidad vital forzada (CVF), presión inspiratoria máxima y presión espiratoria máxima (PIM-PEM). Posterior a esto, la genotipificación fue realizada por polimerase chain reaction (PCR) y electroforesis en gel de agarosa. Las variables fueron sometidas al análisis estadístico correspondiente según su distribución paramétrica, el nivel de significancia establecido fue un p<0,05. La distribución genotípica fue: Ins/Ins: 28 %, Ins/Del: 62 % y Del/Del: 19 %. Las mujeres homocigoto Ins, presentaron mayor PIM y PEM en modelos por genotipos (p=0,043; p=0,0001 respectivamente) y por dominancia (p=0,019; p=0,0008 respectivamente). La distribución genotípica y frecuencia alélica fue similar a la descrita anteriormente en población chilena. Además, las mujeres portadoras del alelo Ins, presentaron mayor PIM y PEM.PALABRAS CLAVE: Presión inspiratoria máxima; Presión espiratoria máxima; Enzima convertidora de angiotensina.

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“…Genetic influences on the regulation of blood flow with exercise are known to contribute to muscle energy metabolism (van Ginkel et al, 2015 ). Particularly, we have identified that a frequent insertion/deletion polymorphism in the gene that codes for angiotensin-converting enzyme ( ACE ) is associated with differences in blood flow with the onset of intense cyclic exercise, and oxygen-dependent mitochondria metabolism as well as with fluctuations in gene expression (Jackman et al, 2008 ; Dimitriou et al, 2010 ; Williams et al, 2017 ; Fluck et al, 2019 ). The implicated genetic mechanism is mediated by differences in the expression of the encoded ACE protease, which processes the main vasoconstrictor peptide, angiotensin 2, and the degradation of the vasodilatative kinin peptides (Jones et al, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

Accelerated Muscle Deoxygenation in Aerobically Fit Subjects During Exhaustive Exercise Is Associated With the ACE Insertion Allele

Gasser

Franchi

Ruoss

et al. 2022

Front. Sports Act. Living

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IntroductionThe insertion/deletion (I/D) polymorphism in the gene for the major regulator of vascular tone, angiotensin-converting enzyme-insertion/deletion (ACE-I/D) affects muscle capillarization and mitochondrial biogenesis with endurance training. We tested whether changes of leg muscle oxygen saturation (SmO2) during exhaustive exercise and recovery would depend on the aerobic fitness status and the ACE I/D polymorphism.MethodsIn total, 34 healthy subjects (age: 31.8 ± 10.2 years, 17 male, 17 female) performed an incremental exercise test to exhaustion. SmO2 in musculus vastus lateralis (VAS) and musculus gastrocnemius (GAS) was recorded with near-IR spectroscopy. Effects of the aerobic fitness status (based on a VO2peak cutoff value of 50 ml O2 min−1 kg−1) and the ACE-I/D genotype (detected by PCR) on kinetic parameters of muscle deoxygenation and reoxygenation were assessed with univariate ANOVA.ResultsDeoxygenation with exercise was comparable in VAS and GAS (p = 0.321). In both leg muscles, deoxygenation and reoxygenation were 1.5-fold higher in the fit than the unfit volunteers. Differences in muscle deoxygenation, but not VO2peak, were associated with gender-independent (p > 0.58) interaction effects between aerobic fitness × ACE-I/D genotype; being reflected in a 2-fold accelerated deoxygenation of VAS for aerobically fit than unfit ACE-II genotypes and a 2-fold higher deoxygenation of GAS for fit ACE-II genotypes than fit D-allele carriers.DiscussionAerobically fit subjects demonstrated increased rates of leg muscle deoxygenation and reoxygenation. Together with the higher muscle deoxygenation in aerobically fit ACE-II genotypes, this suggests that an ACE-I/D genotype-based personalization of training protocols might serve to best improve aerobic performance.

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Angiotensin-converting enzyme gene polymorphism and respiratory muscle function in infants

Cited by 5 publications

References 30 publications

Determinants of inspiratory muscle function in healthy children

Determinants of inspiratory muscle function in healthy children

Influencia del Polimorfismo Inserción / Deleción (rs4646994) del Gen de la Enzima Convertidora de Angiotensina en la Presión Inspiratoria y Espiratoria Máxima de Jóvenes Chilenos Sedentarios

Accelerated Muscle Deoxygenation in Aerobically Fit Subjects During Exhaustive Exercise Is Associated With the ACE Insertion Allele

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